Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment with IL-19 improves locomotor functional recovery after contusion trauma to the spinal cord

(2018) Jidong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages

(2018) Xiao Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lentivirus Mediating FGF13 Enhances Axon Regeneration after Spinal Cord Injury by Stabilizing Microtubule and Improving Mitochondrial Function

(2018) Jiawei Li et al.   JOURNAL OF NEUROTRAUMA

Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management

(2018) Anil Kumar Rana et al.   NEUROPHARMACOLOGY

R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography

(2018) Simona Mrakic-Sposta et al.   Oxidative Medicine and Cellular Longevity

Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway

(2018) Xinnong Liu et al.   Oxidative Medicine and Cellular Longevity

Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway

(2018) Xuan Yang et al.   Frontiers in Cellular Neuroscience

Local Delivery of β-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury

(2018) Jingyu Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis

(2018) Wen-Qi Ma et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Antagonistic Axon-Dendrite Interplay Enables Efficient Neuronal Repair in the Adult Zebrafish Central Nervous System

(2018) An Beckers et al.   MOLECULAR NEUROBIOLOGY

Fibroblast growth factor 21 facilitates peripheral nerve regeneration through suppressing oxidative damage and autophagic cell death

(2018) Yingfeng Lu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation

(2017) Di Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases

(2017) Ganggang Kong et al.   JOURNAL OF NEUROTRAUMA

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease

(2017) P. Kurian et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Methane Suppresses Microglial Activation Related to Oxidative, Inflammatory, and Apoptotic Injury during Spinal Cord Injury in Rats

(2017) WeiHeng Wang et al.   Oxidative Medicine and Cellular Longevity

Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury

(2017) Jian Chen et al.   Cell Death & Disease

Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury

(2017) Zipeng Zhou et al.   Oncotarget

Metformin treatment after the hypoxia-ischemia attenuates brain injury in newborn rats

(2017) Mingchu Fang et al.   Oncotarget

Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo

(2017) Jian-Cai Tang et al.   Cancer Research and Treatment

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Synergistic protective effect of paeoniflorin and β-ecdysterone against rotenone-induced neurotoxicity in PC12 cells

(2016) Han Liu et al.   APOPTOSIS

Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury

(2016) Chen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway

(2016) Dong-Sung Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aescin reduces oxidative stress and provides neuroprotection in experimental traumatic spinal cord injury

(2016) Peng Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich’s ataxia

(2016) Emanuela Piermarini et al.   HUMAN MOLECULAR GENETICS

Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation

(2016) Di Zhang et al.   MOLECULAR NEUROBIOLOGY

Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes

(2016) Bin Zhang et al.   MOLECULES

Intrinsic Control of Axon Regeneration

(2016) Zhigang He et al.   NEURON

Mitochondria Localize to Injured Axons to Support Regeneration

(2016) Sung Min Han et al.   NEURON

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury

(2016) Miao He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

(2015) Rafael P. Vázquez-Manrique et al.   HUMAN MOLECULAR GENETICS

Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity

(2015) Dirleise Colle et al.   MOLECULAR NEUROBIOLOGY

Hypericum perforatum Attenuates Spinal Cord Injury-Induced Oxidative Stress and Apoptosis in the Dorsal Root Ganglion of Rats: Involvement of TRPM2 and TRPV1 Channels

(2015) Ümit Sinan Özdemir et al.   MOLECULAR NEUROBIOLOGY

Beneficial Effect of Metformin on Nerve Regeneration and Functional Recovery After Sciatic Nerve Crush Injury in Diabetic Rats

(2015) Junxiong Ma et al.   NEUROCHEMICAL RESEARCH

Stimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury

(2015) Kai-liang Zhou et al.   Scientific Reports

Extrinsic and intrinsic regulation of axon regeneration at a crossroads

(2015) Andrew Kaplan et al.   Frontiers in Molecular Neuroscience

N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma

(2014) Samir P. Patel et al.   EXPERIMENTAL NEUROLOGY

Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   Journal of Neuroinflammation

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice

(2014) S.P. Patil et al.   NEUROSCIENCE

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS

(2014) J C Koch et al.   Cell Death & Disease

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

Metformin induces up-regulation of blood–brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells

(2013) Fuyuko Takata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Autophagy and Ubiquitinated Protein Accumulation by bFGF Promotes Functional Recovery and Neural Protection in a Rat Model of Spinal Cord Injury

(2013) Hong-Yu Zhang et al.   MOLECULAR NEUROBIOLOGY

From basics to clinical: A comprehensive review on spinal cord injury

(2013) Nuno A. Silva et al.   PROGRESS IN NEUROBIOLOGY

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Simulated microgravity facilitates cell migration and neuroprotection after bone marrow stromal cell transplantation in spinal cord injury

(2013) Takafumi Mitsuhara et al.   Stem Cell Research & Therapy

Management strategies for acute spinal cord injury

(2012) Philip F. Stahel et al.   Current Opinion in Critical Care

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion

(2012) Fatemeh Mohagheghi et al.   NEUROTOXICITY RESEARCH

Taxol Facilitates Axon Regeneration in the Mature CNS

(2011) V. Sengottuvel et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Cysteine Proteases in Acute and Chronic Spinal Cord Injury

(2011) Swapan K. Ray et al.   Neurotherapeutics

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Growing the growth cone: remodeling the cytoskeleton to promote axon regeneration

(2011) Eun-Mi Hur et al.   TRENDS IN NEUROSCIENCES

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

(2010) Ana I. Morales et al.   KIDNEY INTERNATIONAL

Microtubule stabilization specifies initial neuronal polarization

(2008) Harald Witte et al.   JOURNAL OF CELL BIOLOGY