Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation

Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NF-κB and mTOR signaling

(2016) Tharinee Mattaveewong et al.   CARBOHYDRATE POLYMERS

17β-Estradiol Inhibits MMP-9 and SUR1/TrpM4 Expression and Activation and Thereby Attenuates BSCB Disruption/Hemorrhage After Spinal Cord Injury in Male Rats

(2015) Jee Y. Lee et al.   ENDOCRINOLOGY

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

(2015) Rafael P. Vázquez-Manrique et al.   HUMAN MOLECULAR GENETICS

β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1

(2015) ShunYu Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Central role of neutrophil in the pathogenesis of severe acute pancreatitis

(2015) Zhi-wen Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury

(2015) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

(2015) Xiaojing Chen et al.   MOLECULAR NEUROBIOLOGY

Proteasome Inhibition Diminishes the Formation of Neutrophil Extracellular Traps and Prevents the Death of Cardiomyocytes in Coculture with Activated Neutrophils during Anoxia-Reoxygenation

(2015) Denis O. Pashevin et al.   PATHOBIOLOGY

Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro

(2015) Xu Chen et al.   TUMOR BIOLOGY

Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells

(2015) Carminia Maria Della Corte et al.   Oncotarget

Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression

(2014) Shu-Ching Hsieh et al.   AMINO ACIDS

Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway

(2014) Gong-Rak Lee et al.   CLINICAL & EXPERIMENTAL METASTASIS

Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes

(2014) Mohammed Abdelsaid et al.   DIABETES

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria

(2014) Jessica Soto Hernández et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Valsartan independent of AT1receptor inhibits tissue factor, TLR-2 and -4 expression by regulation of Egr-1 through activation of AMPK in diabetic conditions

(2014) Yu Mi Ha et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A protective role of ciglitazone in ox-LDL-induced rat microvascular endothelial cellsviamodulating PPARγ-dependent AMPK/eNOS pathway

(2014) Lei Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neutrophil contribution to spinal cord injury and repair

(2014) Virginie Neirinckx et al.   Journal of Neuroinflammation

Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   Journal of Neuroinflammation

Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice

(2014) Faik Imeri et al.   NEUROPHARMACOLOGY

Current preclinical studies on neuroinflammation and changes in blood–brain barrier integrity by MDMA and methamphetamine

(2014) Esther O'Shea et al.   NEUROPHARMACOLOGY

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice

(2014) S.P. Patil et al.   NEUROSCIENCE

Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   NEUROSCIENCE LETTERS

Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells

(2014) R.-L. Xiang et al.   Journal of Molecular Cell Biology

Metformin induces up-regulation of blood–brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells

(2013) Fuyuko Takata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

17β-Estradiol Protects Human Eyelid-Derived Adipose Stem Cells against Cytotoxicity and Increases Transplanted Cell Survival in Spinal Cord injury

(2013) Jing Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury

(2013) Yu-Kai Zhang et al.   Journal of Neuroinflammation

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Autophagy and Ubiquitinated Protein Accumulation by bFGF Promotes Functional Recovery and Neural Protection in a Rat Model of Spinal Cord Injury

(2013) Hong-Yu Zhang et al.   MOLECULAR NEUROBIOLOGY

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Fluoxetine inhibits transient global ischemia-induced hippocampal neuronal death and memory impairment by preventing blood–brain barrier disruption

(2013) Jee Y. Lee et al.   NEUROPHARMACOLOGY

AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury

(2012) Joshua D. Stone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons

(2012) Ikram Ullah et al.   BMC NEUROSCIENCE

Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood–spinal cord barrier after spinal cord injury

(2012) Jee Y. Lee et al.   BRAIN

The blood-spinal cord barrier: Morphology and Clinical Implications

(2011) Viktor Bartanusz et al.   ANNALS OF NEUROLOGY

Prevention of Both Neutrophil and Monocyte Recruitment Promotes Recovery after Spinal Cord Injury

(2011) Sang Mi Lee et al.   JOURNAL OF NEUROTRAUMA

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Cα-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activat

(2010) Yong P Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin α5β1/αvβ3-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells

(2010) Young-June Jin et al.   CELLULAR SIGNALLING

Negative regulation of stress-induced matrix metalloproteinase-9 by Sirt1 in skin tissue

(2010) Ji-Seon Lee et al.   EXPERIMENTAL DERMATOLOGY

Vascular Protection in Diabetic Stroke: Role of Matrix Metalloprotease-Dependent Vascular Remodeling

(2010) Mostafa M Elgebaly et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of Metformin in Experimental Stroke

(2010) Jun Li et al.   STROKE

Depletion of Ly6G/Gr-1 Leukocytes after Spinal Cord Injury in Mice Alters Wound Healing and Worsens Neurological Outcome

(2009) D. P. Stirling et al.   JOURNAL OF NEUROSCIENCE

The role of the blood–CNS barrier in CNS disorders and their treatment

(2009) Alan M. Palmer   NEUROBIOLOGY OF DISEASE

Effects of zileuton and montelukast in mouse experimental spinal cord injury

(2007) T Genovese et al.   BRITISH JOURNAL OF PHARMACOLOGY