Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway

Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain

(2018) Gabriela Riego et al.   BIOCHEMICAL PHARMACOLOGY

Apolipoprotein E as a novel therapeutic neuroprotection target after traumatic spinal cord injury

(2018) Xiaoxin Cheng et al.   EXPERIMENTAL NEUROLOGY

Methane ameliorates spinal cord ischemia-reperfusion injury in rats: Antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation

(2017) Liping Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord

(2017) Jamie S. Church et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-κB signalling

(2017) Zili He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury

(2017) Jun-peng Pei et al.   Journal of Neuroinflammation

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

(2017) Aarti Narang et al.   Journal of Neuroinflammation

Insights into the Dual Role of Inflammation after Spinal Cord Injury

(2017) Ruslan Rust et al.   JOURNAL OF NEUROSCIENCE

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

(2017) Lucia Machova Urdzikova et al.   NEUROPHARMACOLOGY

Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway

(2017) Haosen Zhao et al.   NEUROSCIENCE

Traumatic Spinal Cord Injury—Repair and Regeneration

(2017) Christopher S. Ahuja et al.   NEUROSURGERY

HowApoE4endangers brains

(2017) Emily Underwood   SCIENCE

Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection

(2017) Jing Li et al.   Frontiers in Cellular Neuroscience

The Role of Netrin-1 in Improving Functional Recovery through Autophagy Stimulation Following Spinal Cord Injury in Rats

(2017) Liangjie Bai et al.   Frontiers in Cellular Neuroscience

An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling

(2017) Le Thi Anh Hong et al.   Nature Communications

ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury

(2017) Zhipeng Teng et al.   Scientific Reports

Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway

(2017) Xiang Xu et al.   Frontiers in Molecular Neuroscience

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

Low-Density Lipoprotein Receptor Deficiency Attenuates Neuroinflammation through the Induction of Apolipoprotein E

(2017) Jo Mailleux et al.   Frontiers in Immunology

Serum protein changes in a rat model of chronic pain show a correlation between animal and humans

(2017) Elisa Bellei et al.   Scientific Reports

Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury

(2016) Katalin Bartus et al.   BRAIN

Aescin reduces oxidative stress and provides neuroprotection in experimental traumatic spinal cord injury

(2016) Peng Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation

(2016) Dina Safina et al.   GLIA

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

(2016) Jeffrey R. Liddell et al.   Journal of Neuroinflammation

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

(2016) Longyu Yang et al.   Journal of Neuroinflammation

Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

(2016) Xin Sun et al.   Journal of Neuroinflammation

Direct Transcriptional Effects of Apolipoprotein E

(2016) V. Theendakara et al.   JOURNAL OF NEUROSCIENCE

APOE genotype and stress response - a mini review

(2016) Janina Dose et al.   Lipids in Health and Disease

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

(2016) Xian Jiang et al.   MOLECULAR CELL

TWEAK-Fn14 Influences Neurogenesis Status via Modulating NF-κB in Mice with Spinal Cord Injury

(2016) Jing Xu et al.   MOLECULAR NEUROBIOLOGY

Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer’s Disease

(2016) Anika Saul et al.   MOLECULAR NEUROBIOLOGY

An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage

(2016) Yue Wu et al.   NEUROSCIENCE LETTERS

Beneficial effects of IL-37 after spinal cord injury in mice

(2016) Marina Coll-Miró et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammogenesis of Secondary Spinal Cord Injury

(2016) M. Akhtar Anwar et al.   Frontiers in Cellular Neuroscience

Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

(2016) Jinwei Pang et al.   Oncotarget

Cellular and subcellular oxidative stress parameters following severe spinal cord injury

(2016) Nishant P. Visavadiya et al.   Redox Biology

Apolipoprotein E s4 Allele and Outcomes of Traumatic Spinal Cord Injury

(2016) Amitabh Jha et al.   JOURNAL OF SPINAL CORD MEDICINE

Applications of the Keap1–Nrf2 system for gene and cell therapy

(2015) Katja M. Kanninen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke

(2015) E. Kim et al.   JOURNAL OF NEUROSCIENCE

Effects of ApoE on intracellular calcium levels and apoptosis of neurons after mechanical injury

(2015) L. Jiang et al.   NEUROSCIENCE

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury

(2014) Ruihua Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Restoring function after spinal cord injury: towards clinical translation of experimental strategies

(2014) Leanne M Ramer et al.   LANCET NEUROLOGY

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?

(2013) Yuriy Pomeshchik et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury

(2013) Valerie Bracchi-Ricard et al.   Journal of Neuroinflammation

Apolipoprotein E and its mimetic peptide suppress Th1 and Th17 responses in experimental autoimmune encephalomyelitis

(2013) Junjie Wei et al.   NEUROBIOLOGY OF DISEASE

Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses

(2013) Josephine Herz et al.   NEUROBIOLOGY OF DISEASE

Butein inhibits NF-κB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats

(2013) Ming Lu et al.   NEUROSCIENCE LETTERS

From basics to clinical: A comprehensive review on spinal cord injury

(2013) Nuno A. Silva et al.   PROGRESS IN NEUROBIOLOGY

Impairment of Gastric Nitrergic and NRF2 System in Apolipoprotein E Knockout Mice

(2012) Kalpana Ravella et al.   DIGESTIVE DISEASES AND SCIENCES

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Apolipoprotein E Sets the Stage: Response to Injury Triggers Neuropathology

(2012) Robert W. Mahley et al.   NEURON

Mechanical injured neurons stimulate astrocytes to express apolipoprotein E through ERK pathway

(2012) Cheng Yin et al.   NEUROSCIENCE LETTERS

Fas/FasL-mediated apoptosis and inflammation are key features of acute human spinal cord injury: implications for translational, clinical application

(2011) Wen Ru Yu et al.   ACTA NEUROPATHOLOGICA

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype—studies in targeted gene replacement mice

(2011) Anne-Christin Graeser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway

(2011) Hui Theng Gan et al.   JOURNAL OF NEUROCHEMISTRY

Activation of the Nuclear Factor E2-Related Factor 2/Antioxidant Response Element Pathway Is Neuroprotective after Spinal Cord Injury

(2011) Xiaoliang Wang et al.   JOURNAL OF NEUROTRAUMA

Disruption of Nrf2 Exacerbated the Damage After Spinal Cord Injury in Mice

(2011) Lei Mao et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Disruption of Nrf2 Enhances the Upregulation of Nuclear Factor-kappaB Activity, Tumor Necrosis Factor-α, and Matrix Metalloproteinase-9 after Spinal Cord Injury in Mice

(2010) Lei Mao et al.   MEDIATORS OF INFLAMMATION

Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo

(2009) Ana Pocivavsek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protection of Neurons from Apoptosis by Apolipoprotein E-containing Lipoproteins Does Not Require Lipoprotein Uptake and Involves Activation of Phospholipase Cγ1 and Inhibition of Calcineurin

(2009) Hideki Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury

(2008) Emanuela Esposito et al.   JOURNAL OF PINEAL RESEARCH

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

(2008) Gilbert Gallardo et al.   NATURE NEUROSCIENCE

Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

(2008) James W. Rowland et al.   Neurosurgical Focus

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

(2007) Dustin J. Donnelly et al.   EXPERIMENTAL NEUROLOGY

Nuclear factor-κB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes

(2007) Danny Salah Rafati et al.   JOURNAL OF NEUROSCIENCE RESEARCH