Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy

Autophagy antagonizes apoptosis induced by flavan enantiomers from Daphne giraldii in hepatic carcinoma cells in vitro

(2017) Qian Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Zosteropenillines: Polyketides from the Marine-Derived Fungus Penicillium thomii

(2017) Shamil Afiyatullov et al.   Marine Drugs

Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells

(2017) Zhuo Yao et al.   Cell Death & Disease

Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia

(2017) Huilin Huang et al.   Scientific Reports

Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose

(2017) Pasquale Dimasi et al.   Scientific Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Anti-tumor activity evaluation of novel chrysin–organotin compound in MCF-7 cells

(2016) Hong-zhuan Xuan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Growth inhibitory effect of paratocarpin E, a prenylated chalcone isolated from Euphorbia humifusa Wild., by induction of autophagy and apoptosis in human breast cancer cells

(2016) Suyu Gao et al.   BIOORGANIC CHEMISTRY

The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway

(2016) Amos C. Hung et al.   CANCER LETTERS

A novel microtubule depolymerizing colchicine analogue triggers apoptosis and autophagy in HCT-116 colon cancer cells

(2016) Ashok Kumar et al.   CELL BIOCHEMISTRY AND FUNCTION

16-hydroxy-cleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2

(2016) Varadharajan Thiyagarajan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Oridonin enhances the anticancer activity of NVP-BEZ235 against neuroblastoma cells in vitro and in vivo through autophagy

(2016) Li-Di Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells

(2016) Shuhui Guo et al.   JOURNAL OF DRUG TARGETING

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

(2016) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells

(2016) Won Kyung Kim et al.   JOURNAL OF NATURAL PRODUCTS

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Natural compound oblongifolin C inhibits autophagic flux, and induces apoptosis and mitochondrial dysfunction in human cholangiocarcinoma QBC939 cells

(2016) Aiqing Zhang et al.   Molecular Medicine Reports

Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells

(2016) Takashi Kasukabe et al.   ONCOLOGY REPORTS

Therapeutic Potential of Curcumin for the Treatment of Brain Tumors

(2016) Neil V. Klinger et al.   Oxidative Medicine and Cellular Longevity

Effective Targeting Survivin, Caspase-3 and MicroRNA-16-1 Expression by Methyl-3-pentyl-6-methoxyprodigiosene Triggers Apoptosis in Colorectal Cancer Stem-Like Cells

(2016) Sohrab Sam et al.   PATHOLOGY & ONCOLOGY RESEARCH

Cytotoxic effects of kazinol A derived from Broussonetia papyrifera on human bladder cancer cells, T24 and T24R2

(2016) Soojong Park et al.   PHYTOMEDICINE

Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation

(2016) Lei Chen et al.   Cell Death & Disease

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer

(2016) Sergey A. Dyshlovoy et al.   Oncotarget

Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells

(2016) Zhao Jing et al.   Oncotarget

Serratia Secondary Metabolite Prodigiosin Inhibits Pseudomonas aeruginosa Biofilm Development by Producing Reactive Oxygen Species that Damage Biological Molecules

(2016) Önder Kimyon et al.   Frontiers in Microbiology

Effect of new berberine derivatives on colon cancer cells

(2015) Luis Miguel Guamán Ortiz et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

(2015) Xuejiao Zhao et al.   Autophagy

Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway

(2015) T. She et al.   Cancer Prevention Research

Lipoic acid inhibits the DNA repair proteinO6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction

(2015) Anja Göder et al.   CARCINOGENESIS

Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity

(2015) Wei-jia Wang et al.   CHEMISTRY & BIOLOGY

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells

(2015) Guowen Ren et al.   Journal of Natural Medicines

Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594

(2015) Yongxiang Song et al.   Marine Drugs

Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult

(2015) Mei-Ling Chan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death

(2015) Man Wu et al.   PHYTOMEDICINE

Betanin-Enriched Red Beetroot (Beta vulgarisL.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells

(2015) Laëtitia Nowacki et al.   PHYTOTHERAPY RESEARCH

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin

(2015) H-Y Tan et al.   Cell Death & Disease

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

(2015) Sergey A. Dyshlovoy et al.   Oncotarget

Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

(2015) Yi WANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model

(2015) Cornelia Braicu et al.   PLoS One

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin

(2015) Zhiyu Wang et al.   Oncotarget

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy

(2014) Afshin Amini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Stereospecific Synthesis of 23-Hydroxyundecylprodiginines and Analogues and Conversion to Antimalarial Premarineosins via a Rieske Oxygenase Catalyzed Bicyclization

(2014) Papireddy Kancharla et al.   JOURNAL OF ORGANIC CHEMISTRY

Stimulation of autophagic activity in human glioma cells by anti-proliferative ardipusilloside I isolated from Ardisia pusilla

(2014) Rong Wang et al.   LIFE SCIENCES

Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells

(2014) Ramin Hassankhani et al.   MEDICAL ONCOLOGY

Honokiol inhibits melanoma stem cells by targeting notch signaling

(2014) Gaurav Kaushik et al.   MOLECULAR CARCINOGENESIS

Novel curcumin analogue IHCH exhibits potent anti-proliferative effects by inducing autophagy in A549 lung cancer cells

(2014) GUANG-ZHOU ZHOU et al.   Molecular Medicine Reports

Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

(2014) Tung-Ho Wu et al.   MOLECULES

Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

(2014) Meng Wang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Synthesis and antimalarial activity of prodigiosenes

(2014) Estelle Marchal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway

(2014) Yujie Fu et al.   PLoS One

A triterpenoid saponin from Adenophora triphylla var. japonica suppresses the growth of human gastric cancer cells via regulation of apoptosis and autophagy

(2014) Jaemoo Chun et al.   TUMOR BIOLOGY

Antimicrobial activity of prodigiosin isolated from Serratia marcescens UFPEDA 398

(2014) J. C. Lapenda et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma

(2013) In-Ja Park et al.   APOPTOSIS

A novel inhibitor, 16-hydroxy-cleroda-3,13-dien-16,15-olide, blocks the autophosphorylation site of focal adhesion kinase (Y397) by molecular docking

(2013) Varadharajan Thiyagarajan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prodigiosin Rescues Deficient p53 Signaling and Antitumor Effects via Upregulating p73 and Disrupting Its Interaction with Mutant p53

(2013) B. Hong et al.   CANCER RESEARCH

The Anticancer Agent Prodigiosin Is Not a Multidrug Resistance Protein Substrate

(2013) Fatemeh Elahian et al.   DNA AND CELL BIOLOGY

Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma Cells

(2013) Bin Li et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

(2013) Dina Permata Sari et al.   Journal of Oleo Science

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells

(2013) Sun-Mi Yun et al.   PHYTOTHERAPY RESEARCH

Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members

(2013) Ali Hosseini et al.   PLoS One

Emblica officinalis Extract Induces Autophagy and Inhibits Human Ovarian Cancer Cell Proliferation, Angiogenesis, Growth of Mouse Xenograft Tumors

(2013) Alok De et al.   PLoS One

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

(2013) Q Deng et al.   Cell Death & Disease

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

(2013) Y Yuan et al.   Cell Death & Disease

Autophagy triggered by magnolol derivative negatively regulates angiogenesis

(2013) S Kumar et al.   Cell Death & Disease

In –silico molecular docking analysis of prodigiosin and cycloprodigiosin as COX-2 inhibitors

(2013) Pabba Shiva Krishna et al.   SpringerPlus

Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells

(2012) Gaurav Kaushik et al.   AMERICAN JOURNAL OF SURGERY

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death

(2012) Chuan Bian Lim et al.   BMC Complementary and Alternative Medicine

Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases

(2012) Z. Wang et al.   CARCINOGENESIS

Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy

(2012) Claudia Torricelli et al.   Evidence-based Complementary and Alternative Medicine

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells

(2012) SHAN ZHAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90

(2012) Wen-Bo Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells

(2012) Cristina P.R. Xavier et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H2O2

(2012) Ghazaleh Rafatian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines

(2012) Mu-Yun Pan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

(2012) Dennis Ma et al.   Jove-Journal of Visualized Experiments

Autophagy as a therapeutic target in cancer

(2011) Ning Chen et al.   CANCER BIOLOGY & THERAPY

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy

(2011) Wenzhuo Zhuang et al.   CANCER SCIENCE

Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K

(2011) Juan-Cheng Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways

(2011) AZHAR RASUL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen

(2011) Dennis Ma et al.   INVESTIGATIONAL NEW DRUGS

Development of natural anti-tumor drugs by microorganisms

(2011) Chia-Che Chang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells

(2011) Hyeonseok Ko et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antimalarial Activity of Natural and Synthetic Prodiginines

(2011) Kancharla Papireddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells

(2011) Yi-Hsiung Lin et al.   LIFE SCIENCES

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells

(2011) Eduardo C. Filippi-Chiela et al.   PLoS One

16-Hydroxycleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis

(2011) Yi-Hsiung Lin et al.   TOXICOLOGY

Prodigiosin inhibits gp91phox and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia–ischemia

(2011) Chia-Che Chang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

New Insights on the Antitumoral Properties of Prodiginines

(2010) R. Perez-Tomas et al.   CURRENT MEDICINAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

(2010) B. Y. K. Law et al.   MOLECULAR CANCER THERAPEUTICS

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

(2010) R R Ruela-de-Sousa et al.   Cell Death & Disease

Resveratrol-induced autophagy in human U373 glioma cells

(2010) MIDORI YAMAMOTO et al.   Oncology Letters

6-Hydroxycleroda-3,13-dien-15,16-olide Protects Neuronal Cells from Lipopolysaccharide-Induced Neurotoxicity through the Inhibition of Microglia-Mediated Inflammation

(2009) Yu-Tzu Shih et al.   PLANTA MEDICA

Cytotoxicity of goniothalamin enantiomers in renal cancer cells: Involvement of nitric oxide, apoptosis and autophagy

(2008) Ângelo de Fátima et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE