Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation

(2015) Jiang-Wei Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration

(2015) Satoshi Suzuki et al.   ARTHRITIS RESEARCH & THERAPY

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

(2014) Gang Hou et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

Mitochondrial bioenergetics, mass, and morphology are altered in cells of the degenerating human annulus

(2013) Helen E. Gruber et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

The effects of microenvironment in mesenchymal stem cell–based regeneration of intervertebral disc

(2013) Yong-Can Huang et al.   Spine Journal

Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

(2013) Nam V. Vo et al.   Spine Journal

Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine

(2011) Huina Zhang et al.   JOURNAL OF NEUROSURGERY-SPINE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Mitochondrial gene expression in the human annulus: in vivo data from annulus cells and selectively harvested senescent annulus cells

(2011) Helen E. Gruber et al.   Spine Journal

Hypoxic Regulation of Nucleus Pulposus Cell Survival

(2010) Makarand V. Risbud et al.   AMERICAN JOURNAL OF PATHOLOGY

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

The effect of needle size inducing degeneration in the rat caudal disc: evaluation using radiograph, magnetic resonance imaging, histology, and immunohistochemistry

(2010) Gun Keorochana et al.   Spine Journal

NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells

(2009) Yvonne D.C. Schilder et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration

(2008) R Ali et al.   BIOTECHNIC & HISTOCHEMISTRY

Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus

(2008) Helen E. Gruber et al.   Spine Journal