Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration
出版年份 2019 全文链接
标题
Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration
作者
关键词
-
出版物
Oxidative Medicine and Cellular Longevity
Volume 2019, Issue -, Pages 1-27
出版商
Hindawi Limited
发表日期
2019-12-31
DOI
10.1155/2019/7810320
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review
- (2019) Shameemah Abrahams et al. NEUROSCIENCE
- Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress
- (2019) Debapriya Chakraborty et al. Redox Biology
- Curcumin protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro
- (2018) Ping Zhao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway
- (2018) Pan Tang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model
- (2018) Yu Chen et al. International Journal of Biological Sciences
- mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
- (2018) Seung Un Seo et al. ONCOGENE
- Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration
- (2018) Jian Chen et al. Cell Death & Disease
- Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy
- (2018) Nisi Zhang et al. Theranostics
- The autophagic response to oxidative stress in osteoarthritic chondrocytes is deregulated
- (2018) Andreas Goutas et al. FREE RADICAL BIOLOGY AND MEDICINE
- AMPK: Potential Therapeutic Target for Ischemic Stroke
- (2018) Shuai Jiang et al. Theranostics
- Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration
- (2018) Yu Song et al. Redox Biology
- TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux
- (2018) Gang Zheng et al. OSTEOARTHRITIS AND CARTILAGE
- LAMP-2B regulates human cardiomyocyte function by mediating autophagosome–lysosome fusion
- (2018) Congwu Chi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders
- (2017) Mahmoud Hashemzaei et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells
- (2017) Xiaobo Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics
- (2017) Laurent-Emmanuel Monfoulet et al. FREE RADICAL BIOLOGY AND MEDICINE
- Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer
- (2017) Sanguine Byun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy
- (2017) Shian-Ren Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2017) Theo Vos et al. LANCET
- Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc
- (2017) Ke Chen et al. Oxidative Medicine and Cellular Longevity
- Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-κB Pathways
- (2017) Chencheng Feng et al. Oxidative Medicine and Cellular Longevity
- ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration
- (2017) Chencheng Feng et al. Oxidative Medicine and Cellular Longevity
- Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy
- (2017) Xiaodong Li et al. Nutrients
- C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis
- (2017) Xiang Zhang et al. Theranostics
- Autophagy: A double-edged sword in intervertebral disk degeneration
- (2016) Shu-Jun Zhang et al. CLINICA CHIMICA ACTA
- Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells
- (2016) Min Li et al. JOURNAL OF PINEAL RESEARCH
- Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration
- (2016) F. Wang et al. OSTEOARTHRITIS AND CARTILAGE
- Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
- (2016) Deheng Chen et al. Cell Death & Disease
- MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis
- (2015) W. Brinjikji et al. AMERICAN JOURNAL OF NEURORADIOLOGY
- Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition
- (2015) KANG XU et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes
- (2015) ZHOUQING HUANG et al. Molecular Medicine Reports
- Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells
- (2015) Shingo Miyazaki et al. ARTHRITIS RESEARCH & THERAPY
- Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy
- (2015) Laura Poillet-Perez et al. Redox Biology
- Oxidative stress participates in age-related changes in rat lumbar intervertebral discs
- (2014) Gang Hou et al. ARCHIVES OF GERONTOLOGY AND GERIATRICS
- Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD
- (2014) Sayak K Mitter et al. Autophagy
- A systematic review and meta-synthesis of the impact of low back pain on people’s lives
- (2014) Robert Froud et al. BMC MUSCULOSKELETAL DISORDERS
- Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?
- (2014) Tiffany Kadow et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice
- (2014) Chen Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The benefits of multi-disciplinary research on intervertebral disc degeneration
- (2014) Hans-Joachim Wilke et al. EUROPEAN SPINE JOURNAL
- SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
- (2014) Wei Jiang et al. Scientific Reports
- Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMP-Activated Protein Kinase
- (2013) Min Young Um et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Primary prevention of disc degeneration-related symptoms
- (2013) Aron Lazary et al. EUROPEAN SPINE JOURNAL
- Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells
- (2013) Kui Xiao et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Comparison of biological processes induced in HepG2 cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol
- (2013) Darina Slamenova et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- The molecular basis of intervertebral disc degeneration
- (2013) Christopher K. Kepler et al. Spine Journal
- Renoprotective effect of the antioxidant curcumin: Recent findings
- (2013) Joyce Trujillo et al. Redox Biology
- Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury
- (2012) Xiucui Ma et al. CIRCULATION
- Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats
- (2012) Wei Ye et al. CONNECTIVE TISSUE RESEARCH
- Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration
- (2012) Libo Jiang et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Curcuminoids and resveratrol as anti-Alzheimer agents
- (2012) Oliver B. Villaflores et al. Taiwanese Journal of Obstetrics & Gynecology
- The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
- (2011) Dan Egan et al. Autophagy
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Discovery of curcumin, a component of golden spice, and its miraculous biological activities
- (2011) Subash C Gupta et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The Effect of Injection Volume on Disc Degeneration in a Rat Tail Model
- (2011) Hua-jie Mao et al. SPINE
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