Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Selective Autophagy: Talking with the UPS

(2013) Caroline Park et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy Protects the Retina from Light-induced Degeneration

(2013) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

(2013) Johanna Viiri et al.   PLoS One

Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells

(2013) J Hanus et al.   Cell Death & Disease

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

(2013) Michael Wong   Biomedical Journal

Autophagy and ageing: Insights from invertebrate model organisms

(2012) Eirini Lionaki et al.   AGEING RESEARCH REVIEWS

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

(2012) Jun Cai et al.   EMBO Molecular Medicine

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium

(2012) Soo-jung Seo et al.   EXPERIMENTAL EYE RESEARCH

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration

(2012) M. Suzuki et al.   JOURNAL OF CELL SCIENCE

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

(2012) Prajitha Thampi et al.   PLoS One

MicroRNA-30b-Mediated Regulation of Catalase Expression in Human ARPE-19 Cells

(2012) Rashidul Haque et al.   PLoS One

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

(2010) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

ARPE-19 retinal pigment epitheliaL CELLS are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron

(2009) Tino Kurz et al.   Autophagy

Autophagy, exosomes and drusen formation in age-related macular degeneration

(2009) Ai Ling Wang et al.   Autophagy

Using LC3 to monitor autophagy flux in the retinal pigment epithelium

(2009) Ai Ling Wang et al.   Autophagy

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Review: Autophagy in neurodegeneration: firefighter and/or incendiarist?

(2009) A. Rami   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Life, death and burial: multifaceted impact of autophagy

(2008) Lorenzo Galluzzi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

To Die or Not to Die: That is the Autophagic Question

(2008) Maria Maiuri et al.   CURRENT MOLECULAR MEDICINE

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

(2008) Tuomas Ryhänen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE