Glycan Mimetics from Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

(2019) Paul M. Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures and functions of invertebrate glycosylation

(2019) Feifei Zhu et al.   Open Biology

Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

(2019) Andrew Tsatsanis et al.   NEUROCHEMICAL RESEARCH

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease

(2019) Chih-Chieh Tao et al.   CELL DEATH AND DIFFERENTIATION

Dysfunction of Cellular Proteostasis in Parkinson’s Disease

(2019) Šárka Lehtonen et al.   Frontiers in Neuroscience

Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks

(2019) Andreia Peixoto et al.   Frontiers in Oncology

Multiple sclerosis and stroke: a systematic review and meta-analysis

(2019) Ye Hong et al.   BMC Neurology

Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor

(2019) Lasse H Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein

(2019) Melissa Birol et al.   PLOS BIOLOGY

Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2

(2018) Yanan Hou et al.   ACS Chemical Neuroscience

Chemoenzymatic Assembly of Mammalian O-Mannose Glycans

(2018) Caicai Meng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics

(2018) John W. Thompson et al.   BIOCHEMISTRY

O-GlcNAc cycling in the developing, adult and geriatric brain

(2018) Olof Lagerlöf   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Glycation affects fibril formation of Aβ peptides

(2018) Alesandro Emendato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse

(2018) Sudhanshu Sahu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Enhanced Neuronal Survival and Neurite Outgrowth Triggered by Novel Small Organic Compounds Mimicking the LewisX Glycan

(2018) Thomas Theis et al.   MOLECULAR NEUROBIOLOGY

Glycoside Mimics from Glycosylamines: Recent Progress

(2018) Cyril Nicolas et al.   MOLECULES

Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson’s disease

(2018) Jay S. Schneider   PLoS One

Folic acid and primary prevention of neural tube defects: A review

(2018) Jan D. van Gool et al.   REPRODUCTIVE TOXICOLOGY

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease

(2018) Annekatrin König et al.   Journal of Parkinsons Disease

Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson’s Disease

(2018) Paula A. Q. Videira et al.   Frontiers in Neuroscience

Molecular pathways associated with oxidative stress in diabetes mellitus

(2018) Osasenaga Macdonald Ighodaro   BIOMEDICINE & PHARMACOTHERAPY

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

(2018) Jyotiska Chaudhuri et al.   Cell Metabolism

GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injury

(2018) Amit Benady et al.   Scientific Reports

Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells

(2018) Andrew R. Yale et al.   Stem Cell Reports

Understanding cellular glycan surfaces in the central nervous system

(2018) Sameera Iqbal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tunicamycin specifically aggravates ER stress and overcomes chemoresistance in multidrug-resistant gastric cancer cells by inhibiting N-glycosylation

(2018) Jian Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

β-Amyloid Accumulation Slows Earlier than Expected in Preclinical Alzheimer's Disease Patients

(2018) Henrique Camara et al.   JOURNAL OF NEUROSCIENCE

Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies

(2018) Jie-Hua Chen et al.   Nutrition & Metabolism

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease

(2018) Guoxin Zhang et al.   Frontiers in Aging Neuroscience

The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease

(2018) Xingyu Zhang et al.   Frontiers in Aging Neuroscience

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

(2018) Gwendoline Bourré et al.   Frontiers in Endocrinology

Nutrient-driven O -GlcNAc in proteostasis and neurodegeneration

(2017) Ilhan Akan et al.   JOURNAL OF NEUROCHEMISTRY

Environmental factors influencing the risk of autism

(2017) Mojgan Karahmadi et al.   Journal of Research in Medical Sciences

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer’s pathology

(2017) Zui Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

(2017) Xin Wang et al.   Frontiers in Molecular Neuroscience

Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function

(2017) Anna Drannik et al.   PLoS One

Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma

(2016) Hussein Abou-Abbass et al.   ELECTROPHORESIS

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis

(2016) Sivabalan Manivannan et al.   JOURNAL OF VIROLOGY

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice

(2016) Judyta K. Juranek et al.   Frontiers in Cellular Neuroscience

Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer

(2016) Fangfang Duan et al.   Oncotarget

Mechanisms of Axonal Damage and Repair after Central Nervous System Injury

(2016) Naohiro Egawa et al.   Translational Stroke Research

Interference effect of oral administration of mulberry branch bark powder on the incidence of type II diabetes in mice induced by streptozotocin

(2016) Hua-Yu Liu et al.   Food & Nutrition Research

The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair

(2016) Vedangana Saini et al.   Scientific Reports

N-linked glycosylation at Asn152 on CD147 affects protein folding and stability: promoting tumour metastasis in hepatocellular carcinoma

(2016) Jiang-Hua Li et al.   Scientific Reports

Protein Glycosylation in Cancer

(2015) Sean R. Stowell et al.   Annual Review of Pathology-Mechanisms of Disease

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

(2015) Y. Kizuka et al.   BIOCHEMICAL JOURNAL

A comprehensive glycome profiling of Huntington's disease transgenic mice

(2015) Solomon T. Gizaw et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

(2015) Y. Kizuka et al.   EMBO Molecular Medicine

Systems biology of neurodegenerative diseases

(2015) Levi B. Wood et al.   Integrative Biology

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Diabetes-associated dysregulation ofO-GlcNAcylation in rat cardiac mitochondria

(2015) Partha S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Gangliosides in Neurodevelopment

(2015) Kate Palmano et al.   Nutrients

The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease

(2015) Shun-Yao Ko et al.   PLoS One

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach

(2014) Parveen Salahuddin et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway

(2014) Jie-Qiong Ma et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: Role in phagocytosis

(2014) Nicholas M Stamatos et al.   GLYCOBIOLOGY

DecreasedO-Linked GlcNAcylation Protects from Cytotoxicity Mediated by Huntingtin Exon1 Protein Fragment

(2014) Amit Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

(2014) Saeed Sadigh-Eteghad et al.   MEDICAL PRINCIPLES AND PRACTICE

Targeting Microtubules by Natural Agents for Cancer Therapy

(2014) E. Mukhtar et al.   MOLECULAR CANCER THERAPEUTICS

Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration

(2014) Ronald L. Schnaar et al.   PHYSIOLOGICAL REVIEWS

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

(2014) Maho Morishima-Kawashima   Frontiers in Physiology

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

(2013) Jason E. Hudak et al.   CHEMISTRY & BIOLOGY

Insulin, cognition, and dementia

(2013) Brenna Cholerton et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of protein glycosylation in Alzheimer disease

(2013) Sophia Schedin-Weiss et al.   FEBS Journal

Glycosylation-independent ERAD pathway serves as a backup system under ER stress

(2013) Ryo Ushioda et al.   MOLECULAR BIOLOGY OF THE CELL

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Neuro-Modulating Effects of Honokiol: A Review

(2013) Anna Woodbury et al.   Frontiers in Neurology

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

(2012) Litao Li et al.   BRAIN RESEARCH

Role of L1CAM for axon sprouting and branching

(2012) Michael K. E. Schäfer et al.   CELL AND TISSUE RESEARCH

Targeting the glycoproteome

(2012) Jonas Nilsson et al.   GLYCOCONJUGATE JOURNAL

Lewis X-carryingN-Glycans Regulate the Proliferation of Mouse Embryonic Neural Stem Cells via the Notch Signaling Pathway

(2012) Hirokazu Yagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells

(2012) Luigina Tagliavacca et al.   JOURNAL OF NEUROCHEMISTRY

The Central Theme of Parkinson’s Disease: α-Synuclein

(2012) Mehmet Ozansoy et al.   MOLECULAR NEUROBIOLOGY

Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2012) Seung-Young Hong et al.   MOLECULES

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Roles of Gangliosides in Neurodevelopment: An Overview of Recent Advances

(2012) Robert K. Yu et al.   NEUROCHEMICAL RESEARCH

Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

(2012) Peng Zhang et al.   NEUROSCIENCE LETTERS

Glycans in Sera of Amyotrophic Lateral Sclerosis Patients and Their Role in Killing Neuronal Cells

(2012) Meital Edri-Brami et al.   PLoS One

Can Alzheimer Disease Be a Form of Type 3 Diabetes?

(2012) Giulia Accardi et al.   REJUVENATION RESEARCH

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity

(2012) G Cisbani et al.   Cell Death & Disease

From glycosylation disorders to dolichol biosynthesis defects: a new class of metabolic diseases

(2011) Vincent Cantagrel et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Structures, Biosynthesis, and Functions of Gangliosides-an Overview

(2011) Robert K. Yu et al.   Journal of Oleo Science

Advanced glycation end products, diabetes, and the brain

(2011) L. H. Coker et al.   NEUROLOGY

Honokiol Crosses BBB and BCSFB, and Inhibits Brain Tumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model

(2011) Xianhuo Wang et al.   PLoS One

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid  -peptides in human cerebrospinal fluid

(2011) A. Halim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

(2011) Haik Mkhikian et al.   Nature Communications

Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF- B Pathway Activation

(2010) J. Lu et al.   CEREBRAL CORTEX

AGE-RAGE in Multiple Sclerosis Brain

(2010) Zohara Sternberg et al.   IMMUNOLOGICAL INVESTIGATIONS

Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders

(2010) Jui-Lung Shen et al.   MOLECULES

Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells

(2010) Chu Peng Hoi et al.   PHYTOTHERAPY RESEARCH

The mouse F3/contactin glycoprotein

(2010) Antonella Bizzoca et al.   Cell Adhesion & Migration

Polysialic acid and activity-dependent synapse remodeling

(2010) Luca Bonfanti et al.   Cell Adhesion & Migration

Protective effect of N-glycan bisecting GlcNAc residues on  -amyloid production in Alzheimer's disease

(2009) K. Akasaka-Manya et al.   GLYCOBIOLOGY

Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells

(2009) Terry D. Butters et al.   GLYCOCONJUGATE JOURNAL

Learning/Memory Impairment and Reduced Expression of the HNK-1 Carbohydrate in β4-Galactosyltransferase-II-deficient Mice

(2009) Toru Yoshihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ aggregation and possible implications in Alzheimer's disease pathogenesis

(2009) Prashant R. Bharadwaj et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glycoproteomics in neurodegenerative diseases

(2009) Hyejin Hwang et al.   MASS SPECTROMETRY REVIEWS

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

HNK-1 (human natural killer-1) glyco-epitope is essential for normal spine morphogenesis in developing hippocampal neurons

(2009) I. Morita et al.   NEUROSCIENCE

Glycosidase inhibition: assessing mimicry of the transition state

(2009) Tracey M. Gloster et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidases: a key to tailored carbohydrates

(2009) Pavla Bojarová et al.   TRENDS IN BIOTECHNOLOGY

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

(2008) K. Balakrishnan et al.   BLOOD

Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro

(2008) Cindy Simoens et al.   BMC CANCER

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

(2008) E. Malito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antioxidative and Anti-Inflammatory Protection of Oleanolic Acid and Ursolic Acid in PC12 Cells

(2008) Shih-Jei Tsai et al.   JOURNAL OF FOOD SCIENCE

Elucidation of O-Glycosylation Structures of the β-Amyloid Precursor Protein by Liquid Chromatography−Mass Spectrometry Using Electron Transfer Dissociation and Collision Induced Dissociation

(2008) Irina Perdivara et al.   JOURNAL OF PROTEOME RESEARCH

Ursolic acid: An anti- and pro-inflammatory triterpenoid

(2008) Yasutaka Ikeda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Recognition and Retrotranslocation of Misfolded Proteins from the Endoplasmic Reticulum

(2008) Kunio Nakatsukasa et al.   TRAFFIC

Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1

(2007) Roger Pocock et al.   MOLECULAR AND CELLULAR NEUROSCIENCE