Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease

Glyceraldehyde-3-phosphate dehydrogenase: Aggregation mechanisms and impact on amyloid neurodegenerative diseases

(2017) Vladimir I. Muronetz et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

(2017) Sebastian Brings et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of diabetes mellitus on longitudinal atrophy and cognition in Parkinson's disease

(2017) Marissa Ong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

(2017) Dilan Athauda et al.   LANCET

Increased risk of Parkinson disease with diabetes mellitus in a population-based study

(2017) Yu-Wan Yang et al.   MEDICINE

Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease

(2017) Jean-Pierre Trezzi et al.   MOVEMENT DISORDERS

Glitazone use associated with reduced risk of Parkinson's disease

(2017) Brage Brakedal et al.   MOVEMENT DISORDERS

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease

(2017) Nikita Katila et al.   NEUROPHARMACOLOGY

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

Evolution of Complex Maillard Chemical Reactions, Resolved in Time

(2017) Daniel Hemmler et al.   Scientific Reports

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

(2017) N. Plotegher et al.   Scientific Reports

Diabetes, Gray Matter Loss, and Cognition in the Setting of Parkinson Disease

(2016) M. Petrou et al.   ACADEMIC RADIOLOGY

Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans

(2016) Owen R. Kinsky et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies

(2016) Yousif A. Shamsaldeen et al.   CURRENT DRUG METABOLISM

Inhibition of endoplasmic reticulum stress-activated IRE1α-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson's disease

(2016) Qiang Tong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antibody-based detection of advanced glycation end-products: promises vs. limitations

(2016) Ryoji Nagai et al.   GLYCOCONJUGATE JOURNAL

Pathways of the Maillard reaction under physiological conditions

(2016) Christian Henning et al.   GLYCOCONJUGATE JOURNAL

Mass spectrometric determination of early and advanced glycation in biology

(2016) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

(2016) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification

(2016) Daniel H. Pfaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroendocrine abnormalities in Parkinson's disease

(2016) Eduardo De Pablo-Fernández et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Risk of Parkinson Disease in Diabetes Mellitus

(2016) Xuejing Yue et al.   MEDICINE

Glycation in Parkinson's disease and Alzheimer's disease

(2016) Hugo Vicente Miranda et al.   MOVEMENT DISORDERS

Nonmotor features of Parkinson's disease subtypes

(2016) Connie Marras et al.   MOVEMENT DISORDERS

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinsons disease

(2016) A. Ghosh et al.   Science Translational Medicine

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons

(2016) Jacqueline A. Bayliss et al.   PLoS One

Glycation potentiates neurodegeneration in models of Huntington’s disease

(2016) Hugo Vicente Miranda et al.   Scientific Reports

Thiazolidinediones and Parkinson Disease: A Cohort Study

(2015) John G. Connolly et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

(2015) Dionne E.M. Maessen et al.   CLINICAL SCIENCE

Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study

(2015) Antonio Costantini et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

(2015) Anna Villar-Piqué et al.   JOURNAL OF NEUROCHEMISTRY

Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial

(2015)   LANCET NEUROLOGY

Biomarkers of cognitive decline in Parkinson's disease

(2015) Chin-Hsien Lin et al.   PARKINSONISM & RELATED DISORDERS

Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study

(2015) Ruth Brauer et al.   PLOS MEDICINE

Effect of Metformin on Methylglyoxal Metabolism in Patients with Type 2 Diabetes

(2014) Z. Kender et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

(2014) Gilbert Richarme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telmisartan Reduces Progressive Oxidative Stress and Phosphorylated α-Synuclein Accumulation in Stroke-resistant Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion

(2014) Kota Sato et al.   Journal of Stroke & Cerebrovascular Diseases

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice

(2014) S.P. Patil et al.   NEUROSCIENCE

Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease

(2014) Nicolaas I. Bohnen et al.   PARKINSONISM & RELATED DISORDERS

Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies

(2014) Lin Lu et al.   PLoS One

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

(2014) L Zondler et al.   Cell Death & Disease

Environmental Toxins and Parkinson's Disease

(2013) Samuel M. Goldman   Annual Review of Pharmacology and Toxicology

The Beneficial Role of Thiamine in Parkinson Disease

(2013) Khanh v. q. Lương et al.   CNS Neuroscience & Therapeutics

High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial

(2013) F. Alaei Shahmiri et al.   EUROPEAN JOURNAL OF NUTRITION

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

(2013) G. Vistoli et al.   FREE RADICAL RESEARCH

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

(2013) Laura Dunn et al.   NEUROBIOLOGY OF AGING

Exposure to pesticides or solvents and risk of Parkinson disease

(2013) G. Pezzoli et al.   NEUROLOGY

Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice

(2013) Sekar Sathiya et al.   NEUROPHARMACOLOGY

Shared dysregulated pathways lead to Parkinson's disease and diabetes

(2013) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Meta-analysis of early nonmotor features and risk factors for Parkinson disease

(2012) Alastair J. Noyce et al.   ANNALS OF NEUROLOGY

Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications

(2012) Y. Sun et al.   DIABETES CARE

Where does plasma methylglyoxal originate from?

(2012) Miklós Péter Kalapos   DIABETES RESEARCH AND CLINICAL PRACTICE

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

Dopamine-derived Quinones Affect the Structure of the Redox Sensor DJ-1 through Modifications at Cys-106 and Cys-53

(2012) Stefania Girotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thiamine and Parkinson's disease

(2012) Khanh vinh quô′c Lương et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Metabolic markers or conditions preceding Parkinson's disease: A case-control study

(2012) Rodolfo Savica et al.   MOVEMENT DISORDERS

Clinical features of Parkinson disease when onset of diabetes came first: A case-control study

(2012) E. Cereda et al.   NEUROLOGY

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

(2012) Mark L. Wahlqvist et al.   PARKINSONISM & RELATED DISORDERS

Diabetes and Risk of Parkinson's Disease

(2011) Q. Xu et al.   DIABETES CARE

Obesity, diabetes, and risk of Parkinson's disease

(2011) Natalia Palacios et al.   MOVEMENT DISORDERS

Glyoxalase in diabetes, obesity and related disorders

(2011) Naila Rabbani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dopamine quinones interact with α-synuclein to form unstructured adducts

(2010) Marco Bisaglia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nɛ-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model

(2010) Yeong-Gon Choi et al.   BIOCHIMIE

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

(2010) Alexander Kurz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

(2010) N. Karachalias et al.   DIABETOLOGIA

Ribosylation Rapidly Induces α-Synuclein to Form Highly Cytotoxic Molten Globules of Advanced Glycation End Products

(2010) Lan Chen et al.   PLoS One

The sour side of neurodegenerative disorders: the effects of protein glycation

(2009) Hugo Vicente Miranda et al.   JOURNAL OF PATHOLOGY

Diabetes preceding Parkinson's disease onset. A case–control study

(2009) Marco D'Amelio et al.   PARKINSONISM & RELATED DISORDERS

The modification of α-synuclein by dicarbonyl compounds inhibits its fibril-forming process

(2008) Daekyun Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease

(2008) J. A. Driver et al.   DIABETES CARE

Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation

(2008) Shamim Shaikh et al.   JOURNAL OF NEUROSCIENCE RESEARCH