An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Acetylation Disfavors Tau Phase Separation

(2018) Josephine Ferreon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy

(2018) Sonia Kapoor et al.   Scientific Reports

Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro

(2017) Jitendra Subhash Rane et al.   JOURNAL OF ALZHEIMERS DISEASE

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

(2017) Megan E. Larson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

(2017) Nadine Ait-Bouziad et al.   Nature Communications

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway

(2016) Tao Yun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

(2016) Elisa Belluzzi et al.   Molecular Neurodegeneration

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation

(2016) Derrick J. Morton et al.   Oncotarget

Albumin stabilized gold nanostars: a biocompatible nanoplatform for SERS, CT imaging and photothermal therapy of cancer

(2016) Sisini Sasidharan et al.   RSC Advances

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Tau co-organizes dynamic microtubule and actin networks

(2015) Auréliane Elie et al.   Scientific Reports

Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression

(2015) Soline Aubry et al.   PLoS One

Quantitative Analysis of Tau-Microtubule Interaction Using FRET

(2014) Isabelle Maïo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

(2014) Anna Mietelska-Porowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

(2013) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

(2013) David J. Irwin et al.   AMERICAN JOURNAL OF PATHOLOGY

Microtubules in neurons as information carriers

(2013) Erik W. Dent et al.   JOURNAL OF NEUROCHEMISTRY

The microtubule-associated tau protein has intrinsic acetyltransferase activity

(2013) Todd J Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characteristics of Tau Oligomers

(2013) Yan Ren et al.   Frontiers in Neurology

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Tau Isoform Composition Influences Rate and Extent of Filament Formation

(2012) Qi Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability

(2012) Katharina Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H4 K16Q Mutation, an Acetylation Mimic, Causes Structural Disorder of Its N-Terminal Basic Patch in the Nucleosome

(2012) Bing-Rui Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Golgi Bypass: Skirting Around the Heart of Classical Secretion

(2011) A. G. Grieve et al.   Cold Spring Harbor Perspectives in Biology

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Characteristics and consequences of muscarinic receptor activation by tau protein

(2009) Alberto Gómez-Ramos et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Dendrites differ from axons in patterns of microtubule stability and polymerization during development

(2009) Katherine M Kollins et al.   Neural Development

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY