Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

(2019) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Quality Control of the Endoplasmic Reticulum and Ubiquitin–Proteasome-Triggered Degradation of Aberrant Proteins: Yeast Pioneers the Path

(2018) Nicole Berner et al.   Annual Review of Biochemistry

Squalene epoxidase as a promising metabolic target in cancer treatment

(2018) Gabriella Cirmena et al.   CANCER LETTERS

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

(2018) Sandra Stefanovic‐Barrett et al.   EMBO REPORTS

“Mallostery”—ligand-dependent protein misfolding enables physiological regulation by ERAD

(2018) Margaret A Wangeline et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates

(2018) Edmond Y. Huang et al.   MOLECULAR BIOLOGY OF THE CELL

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Mallostery: Filling a niche between quality and metabolic control

(2018) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol increases protein levels of the E3 ligase MARCH6, and thereby stimulates protein degradation

(2018) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis

(2018) Josephine M.E. Tan et al.   ATHEROSCLEROSIS

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

(2017) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)

(2017) Jasmin Schulz et al.   JOURNAL OF CELL SCIENCE

Endoplasmic Reticulum–Associated Degradation and Lipid Homeostasis

(2016) Julian Stevenson et al.   Annual Review of Nutrition

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer

(2016) David N. Brown et al.   Scientific Reports

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis

(2015) Masanori Honsho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

(2015) Vicky Howe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron

(2015) Gregor Habeck et al.   JOURNAL OF CELL BIOLOGY

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

(2015) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

(2014) Matthew Locke et al.   BIOCHEMICAL JOURNAL

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids

(2014) Julian Stevenson et al.   BIOCHEMICAL JOURNAL

Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein

(2014) Antonio D. Konitsiotis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

(2014) Lindsey L. Morris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Topology of Hedgehog Acyltransferase

(2014) Armine Matevossian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

(2014) Yanfen Liu et al.   eLife

Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells

(2013) Anika Vinayak Prabhu et al.   FEBS LETTERS

Architectural Organization of the Metabolic Regulatory Enzyme GhrelinO-Acyltransferase

(2013) Martin S. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

(2013) Dimitrios Zattas et al.   MOLECULAR BIOLOGY OF THE CELL

A Practical Comparison of Ligation-Independent Cloning Techniques

(2013) Julian Stevenson et al.   PLoS One

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation

(2013) M. L. Burr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

(2013) Ombretta Foresti et al.   eLife

Roles of p97-Associated Deubiquitinases in Protein Quality Control at the Endoplasmic Reticulum

(2012) Yanfen Liu et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate

(2012) Ryan E. Tyler et al.   MOLECULAR BIOLOGY OF THE CELL

Squalene monooxygenase – a target for hypercholesterolemic therapy

(2011) Agnieszka Belter et al.   BIOLOGICAL CHEMISTRY

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope

(2011) Noa Furth et al.   MOLECULAR BIOLOGY OF THE CELL

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

(2010) Youngah Jo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation

(2009) Gil S. Leichner et al.   MOLECULAR BIOLOGY OF THE CELL

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER

(2009) Robert Ernst et al.   MOLECULAR CELL

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL