Vascular Risk Factors and Alzheimer’s Disease: Blood-Brain Barrier Disruption, Metabolic Syndromes, and Molecular Links

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Prevention of Cognitive Impairment With Intensive Systolic Blood Pressure Control

(2019) Kristine Yaffe   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of Conjunctive Binding in Aging: A Promising Approach for Alzheimer’s Disease Detection

(2019) Juan F. Martínez et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets

(2018) Santa Mammana et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes

(2018) Ying Du et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals

(2018) Jennifer S. Rabin et al.   JAMA Neurology

Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events

(2018) Cristina Carvalho et al.   Frontiers in Physiology

Alzheimer's disease and Type 2 Diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

(2018) Yevgen Chornenkyy et al.   BRAIN PATHOLOGY

Loss of Astrocyte Polarization in the Tg-ArcSwe Mouse Model of Alzheimer's Disease

(2018) Jing Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease

(2018) Larissa Lobo Torres et al.   JOURNAL OF ALZHEIMERS DISEASE

The Saturated Fatty Acid Palmitate Induces Human Monocytic Cell Toxicity Toward Neuronal Cells: Exploring a Possible Link Between Obesity-Related Metabolic Impairments and Neuroinflammation

(2018) Jonathan P. Little et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein E Genotype and Cerebrovascular Alterations Can Influence Conversion to Dementia in Patients with Mild Cognitive Impairment

(2018) Giovanna Viticchi et al.   JOURNAL OF ALZHEIMERS DISEASE

Common Mechanisms of Alzheimer's Disease and Ischemic Stroke: The Role of Protein Kinase C in the Progression of Age-Related Neurodegeneration

(2018) Brandon P. Lucke-Wold et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Protein Dysfunction after Brain Ischemia

(2018) Ryszard Pluta et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Cognitive Reserve in Alzheimer’s Disease and Aging: A Multi-Modal Imaging Review

(2018) Arianna Menardi et al.   JOURNAL OF ALZHEIMERS DISEASE

Nitrendipine and Dementia: Forgotten Positive Facts?

(2018) Michal Novotny et al.   Frontiers in Aging Neuroscience

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Rho-associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease

(2017) Aaron Y. Lai et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte and Alzheimer’s disease

(2017) Zhiyou Cai et al.   JOURNAL OF NEUROLOGY

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

(2017) Gargi Banerjee et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol

(2017) Joao Prola Netto et al.   NEUROSURGERY

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

(2017) S. Alford et al.   Obesity Reviews

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

(2017) Charles Caër et al.   Scientific Reports

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies

(2017) Diana L Castillo-Carranza et al.   Aging and Disease

Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer’s disease

(2017) Anna Csiszar et al.   GeroScience

Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology

(2017) Stuart Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease

(2017) David H. Small et al.   JOURNAL OF ALZHEIMERS DISEASE

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

High Serum Levels of Malondialdehyde and 8-OHdG are both Associated with Early Cognitive Impairment in Patients with Acute Ischaemic Stroke

(2017) Zhihua Liu et al.   Scientific Reports

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy

(2016) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

(2016) Stefano Tarantini et al.   AGE

The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment

(2016) Osigbemhe Iyalomhe et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links

(2016) Murali Vijayan et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice

(2016) Lin Kooi Ong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiotensin II, hypertension and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease

(2016) Maximilian Wiesmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammasomes link vascular disease with neuroinflammation and brain disorders

(2016) Nikolett Lénárt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia—Induced vascular dementia of rats

(2016) Yanjing Cao et al.   NEUROSCIENCE LETTERS

Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model

(2016) Yinzhong Ma et al.   PHARMACOLOGICAL RESEARCH

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Long-Term Risk of Dementia Among Survivors of Ischemic or Hemorrhagic Stroke

(2016) Priscila Corraini et al.   STROKE

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

(2016) Yue Zhang et al.   Beilstein Journal of Nanotechnology

The cingulate island sign within early Alzheimer’s disease-specific hypoperfusion volumes of interest is useful for differentiating Alzheimer’s disease from dementia with Lewy bodies

(2016) Etsuko Imabayashi et al.   EJNMMI Research

Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice

(2016) Riya Thomas et al.   Acta Neuropathologica Communications

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

A Polymorphism Within the 3′UTR of NLRP3 is Associated with Susceptibility for Ischemic Stroke in Chinese Population

(2015) Zhansheng Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The neuropathology and cerebrovascular mechanisms of dementia

(2015) Limor Raz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

(2015) Melanie D Sweeney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aβ42 and Aβ40: similarities and differences

(2015) Tian Qiu et al.   JOURNAL OF PEPTIDE SCIENCE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated

(2015) Adam M. Brickman et al.   NEUROSCIENCE LETTERS

The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer’s Disease and Vascular Dementia

(2015) Maria Luca et al.   Oxidative Medicine and Cellular Longevity

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

(2015) J H Birnbaum et al.   Cell Death & Disease

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Progress on diabetic cerebrovascular diseases

(2015) Houguang Zhou et al.   Bosnian Journal of Basic Medical Sciences

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

(2014) Ana Catarina R. G. Fonseca et al.   MOLECULAR NEUROBIOLOGY

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

(2014) David S. Knopman et al.   NEUROBIOLOGY OF AGING

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

(2014) Yang Zhao et al.   Frontiers in Aging Neuroscience

The effects of hypertension on the cerebral circulation

(2013) Paulo W. Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calcium channel blockers and dementia

(2013) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased Alzheimer’s Disease Neuropathology is Associated with Type 2 Diabetes and ApoE ε4 Carrier Status

(2013) Michael Malek-Ahmadi et al.   Current Alzheimer Research

Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes

(2013) Javier Pacheco-Quinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia

(2013) Carlo Cervellati et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Protein Kinase C -Calcineurin Cosignaling Downstream of Toll-Like Receptor 4 Downregulates Fibrosis and Induces Wound Healing Gene Expression in Cardiac Myofibroblasts

(2013) R. F. D. S. Mesquita et al.   MOLECULAR AND CELLULAR BIOLOGY

Alzheimer disease and risk of stroke: A population-based cohort study

(2013) N.-F. Chi et al.   NEUROLOGY

APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease

(2013) Ivar Reinvang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation

(2013) Ayman ElAli et al.   Acta Neuropathologica Communications

Peroxisome proliferator-activated receptor-γ protects against vascular aging

(2012) Mary L. Modrick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The downward spiral of tau and autolysosomes

(2012) Suren S. Ambegaokar et al.   Autophagy

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Impaired Neurovascular Coupling in the APPxPS1 Mouse Model of Alzheimer’s Disease

(2012) Armelle Rancillac et al.   Current Alzheimer Research

An update on type 2 diabetes, vascular dementia and Alzheimer's disease

(2012) L.G. Exalto et al.   EXPERIMENTAL GERONTOLOGY

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Diabetes, hyperglycaemia, and acute ischaemic stroke

(2012) Merel JA Luitse et al.   LANCET NEUROLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

(2012) Michelle A. Erickson et al.   NEUROIMMUNOMODULATION

Lipid Rafts and Alzheimer’s Disease: Protein-Lipid Interactions and Perturbation of Signaling

(2012) David A. Hicks et al.   Frontiers in Physiology

‘Alzheimer-like’ pathology in a murine model of arterial hypertension

(2011) Daniela Carnevale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Monocytic microparticles activate endothelial cells in an IL-1 -dependent manner

(2011) J.-G. Wang et al.   BLOOD

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

(2011) Paula Grammas   Journal of Neuroinflammation

Iron deficiency can cause cognitive impairment in geriatric patients

(2011) Burcu Balam Yavuz et al.   Journal of Nutrition Health & Aging

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction

(2011) Nasim Mansoori et al.   NEUROBIOLOGY OF AGING

Microstructural white matter abnormalities in type 2 diabetes mellitus: A diffusion tensor imaging study

(2011) Jung-Lung Hsu et al.   NEUROIMAGE

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

(2011) Jia-Min Zhuo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Calcium Control of Neurotransmitter Release

(2011) T. C. Sudhof   Cold Spring Harbor Perspectives in Biology

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

(2010) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Cognitive dysfunction in patients with type 2 diabetes

(2010) Yael D. Reijmer et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?

(2010) Christian Humpel   EXPERIMENTAL GERONTOLOGY

Does Serum Tau Protein Predict the Outcome of Patients with Ischemic Stroke?

(2010) Joanna Bielewicz et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease

(2010) Brian Jeynes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis

(2010) Brian Jeynes et al.   NEUROSCIENCE LETTERS

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

β-Amyloid, Blood Vessels, and Brain Function

(2009) Eric E. Smith et al.   STROKE

Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes

(2008) Valentina Cecarini et al.   BRAIN RESEARCH

Tissue Plasminogen Activator Enhances the Hypoxia/reoxygenation-induced Impairment of the Blood–brain Barrier in a Primary Culture of Rat Brain Endothelial Cells

(2008) Takeshi Hiu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Evidence for Altered LRP/RAGE Expression in Alzheimer Lesion Pathogenesis

(2008) Brian Jeynes et al.   Current Alzheimer Research

Predictors of Cognitive Decline in Older Individuals With Diabetes

(2008) D. G. Bruce et al.   DIABETES CARE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY