Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

(2019) Heledd H Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions

(2019) Solomiia Boyko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β

(2019) Kazuhiro Irie   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus

(2018) Chihiro Akiba et al.   JOURNAL OF ALZHEIMERS DISEASE

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease

(2018) Soyoon Sarah Hwang et al.   ANALYTICAL BIOCHEMISTRY

Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

(2018) T. Sarajärvi et al.   NEUROPHARMACOLOGY

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

(2018) Thomas O. Vogler et al.   NATURE

Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer’s Disease Phase IIa and Expanded Access Trials

(2017) Thomas J. Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

(2017) Paul A. Wender et al.   SCIENCE

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer’s Disease

(2017) Takayuki Kondo et al.   Cell Reports

nELAV Proteins Alteration in Alzheimer's Disease Brain: A Novel Putative Target for Amyloid-β Reverberating on AβPP Processing

(2017) Marialaura Amadio et al.   JOURNAL OF ALZHEIMERS DISEASE

PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells

(2016) Nicoletta Marchesi et al.   JOURNAL OF ALZHEIMERS DISEASE

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semisynthesis and Structure–Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation

(2016) Takuya Yoshioka et al.   JOURNAL OF NATURAL PRODUCTS

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis

(2016) Kazuma Murakami et al.   Scientific Reports

Amyloid biomarkers in Alzheimer's disease

(2015) Kaj Blennow et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

(2015) Tomohiro Umeda et al.   Acta Neuropathologica Communications

Predicting Alzheimer disease with β-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing

(2014) Christopher C. Rowe et al.   ANNALS OF NEUROLOGY

Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2014) Naoki KANEKO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

(2014) Masato Nakagawa et al.   Scientific Reports

HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

(2014) Min-Ju Kang et al.   Cell Reports

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes

(2013) Javier Pacheco-Quinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

(2013) Mizuho Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of Aβ42

(2012) Naotaka Izuo et al.   ACS Chemical Neuroscience

Structure–Activity Studies on the Spiroketal Moiety of a Simplified Analogue of Debromoaplysiatoxin with Antiproliferative Activity

(2012) Masayuki Kikumori et al.   JOURNAL OF MEDICINAL CHEMISTRY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI

(2011) Leslie M. Shaw et al.   ACTA NEUROPATHOLOGICA

PKC   Activation Prevents Synaptic Loss, A  Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

(2011) J. Hongpaisan et al.   JOURNAL OF NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Specificity and sensitivity of the Abeta oligomer ELISA

(2010) Andrea C. Klaver et al.   JOURNAL OF NEUROSCIENCE METHODS

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

A Specific Enzyme-Linked Immunosorbent Assay for Measuring β-Amyloid Protein Oligomers in Human Plasma and Brain Tissue of Patients With Alzheimer Disease

(2009) Weiming Xia et al.   ARCHIVES OF NEUROLOGY

Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

(2009) Yuichi Masuda et al.   CHEMBIOCHEM

A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible Protein Kinase C Activator with Bryostatin-like Activity

(2009) Yu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts

(2009) Tapan K. Khan et al.   NEUROBIOLOGY OF DISEASE

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

(2008) Barry M. Trost et al.   NATURE