Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer’s Disease Phase IIa and Expanded Access Trials

Molecular regulation of synaptogenesis during associative learning and memory

(2015) Thomas J. Nelson et al.   BRAIN RESEARCH

ApoE4 and A  Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation

(2015) A. Sen et al.   JOURNAL OF NEUROSCIENCE

Towards universal therapeutics for memory disorders

(2015) Miao-Kun Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Phase I Study of Temsirolimus and Bryostatin-1 in Patients With Metastatic Renal Cell Carcinoma and Soft Tissue Sarcoma

(2014) E. R. Plimack et al.   ONCOLOGIST

PKCε Promotes HuD-Mediated Neprilysin mRNA Stability and Enhances Neprilysin-Induced Aβ Degradation in Brain Neurons

(2014) Chol Seung Lim et al.   PLoS One

Cerebral ischemia-induced difference in sensitivity to depression and potential therapeutics in rats

(2013) Miao-Kun Sun et al.   BEHAVIOURAL PHARMACOLOGY

Adduct formation in liquid chromatography-triple quadrupole mass spectrometric measurement of bryostatin 1

(2013) Thomas J. Nelson et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

PKC activation during training restores mushroom spine synapses and memory in the aged rat

(2013) Jarin Hongpaisan et al.   NEUROBIOLOGY OF DISEASE

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

(2013) Zhenjun Tan et al.   STROKE

Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture

(2012) Chol Seung Lim et al.   HIPPOCAMPUS

Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ

(2012) Abhik Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bryostatin-1 promotes long-term potentiation via activation of PKCα and PKCε in the hippocampus

(2012) H. Kim et al.   NEUROSCIENCE

PKC   Activation Prevents Synaptic Loss, A  Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

(2011) J. Hongpaisan et al.   JOURNAL OF NEUROSCIENCE

Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study

(2010) Robert J. Morgan et al.   INVESTIGATIONAL NEW DRUGS

Protein Kinase C Activators as Synaptogenic and Memory Therapeutics

(2009) Miao-Kun Sun et al.   ARCHIV DER PHARMAZIE

Reduction of β-Amyloid Levels by Novel Protein Kinase Cϵ Activators

(2009) Thomas J. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective versus tumorigenic protein kinase C activators

(2009) T.J. Nelson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

(2008) Geoffrey Y. Ku et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains

(2008) M.-K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA