New diagnostic method for Alzheimer’s disease based on the toxic conformation theory of amyloid β

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment

(2019) Nicklas Österlund et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease

(2019) Naotaka Izuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties

(2019) Kazuma Murakami et al.   MOLECULES

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine

(2018) Mizuho Hanaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers

(2018) Kazuma Murakami et al.   CHEMICAL COMMUNICATIONS

Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus

(2018) Chihiro Akiba et al.   JOURNAL OF ALZHEIMERS DISEASE

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Are antibodies directed against amyloid-β (Aβ) oligomers the last call for the Aβ hypothesis of Alzheimer's disease?

(2018) Francesco Panza et al.   Immunotherapy

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

(2017) Harutsugu Tatebe et al.   Molecular Neurodegeneration

Alzheimer's disease as oligomeropathy

(2017) Kenjiro Ono   NEUROCHEMISTRY INTERNATIONAL

Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

(2017) Paul A. Wender et al.   SCIENCE

A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease

(2017) Naotaka Izuo et al.   Scientific Reports

Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids

(2016) Mizuho Hanaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Semisynthesis and Structure–Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation

(2016) Takuya Yoshioka et al.   JOURNAL OF NATURAL PRODUCTS

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

(2016) Veronika Logovinsky et al.   Alzheimers Research & Therapy

THE BRYOSTATINS’ TALE

(2016) BETHANY HALFORD   CHEMICAL & ENGINEERING NEWS

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis

(2016) Kazuma Murakami et al.   Scientific Reports

Synthesis of chemically-tethered amyloid-β segment trimer possessing amyloidogenic properties

(2015) Kiyomichi Shinoda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers

(2015) Danting Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils

(2014) Christofer Lendel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

(2014) Tiernan T. O’Malley et al.   BIOCHEMICAL JOURNAL

Synthesis and Biological Activities of Simplified Analogs of the Natural PKC Ligands, Bryostatin-1 and Aplysiatoxin

(2014) Kazuhiro Irie et al.   CHEMICAL RECORD

X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ17–36

(2014) Ryan K. Spencer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

(2013) Andrew D. Watt et al.   ACTA NEUROPATHOLOGICA

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

(2013) Mizuho Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

(2013) W. Mei Kok et al.   Chemical Science

Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of Aβ42

(2012) Naotaka Izuo et al.   ACS Chemical Neuroscience

Structure–Activity Studies on the Spiroketal Moiety of a Simplified Analogue of Debromoaplysiatoxin with Antiproliferative Activity

(2012) Masayuki Kikumori et al.   JOURNAL OF MEDICINAL CHEMISTRY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

(2011) Robert J. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ion Mobility Separation Coupled with MS Detects Two Structural States of Alzheimer's Disease Aβ1–40 Peptide Oligomers

(2011) Marcin Kłoniecki et al.   JOURNAL OF MOLECULAR BIOLOGY

Rigid P-Chiral Phosphine Ligands with tert-Butylmethylphosphino Groups for Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

(2011) Tsuneo Imamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monoclonal Antibody Against the Turn of the 42-Residue Amyloid β-Protein at Positions 22 and 23

(2010) Kazuma Murakami et al.   ACS Chemical Neuroscience

A Disulfide-Linked Amyloid-β Peptide Dimer Forms a Protofibril-like Oligomer through a Distinct Pathway from Amyloid Fibril Formation

(2010) Takahiro Yamaguchi et al.   BIOCHEMISTRY

Amyloid  -Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

(2010) B. O'Nuallain et al.   JOURNAL OF NEUROSCIENCE

Natural products as a source of Alzheimer's drug leads

(2010) Philip Williams et al.   NATURAL PRODUCT REPORTS

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Taxonomy and function of C1 protein kinase C homology domains

(2010) James H. Hurley et al.   PROTEIN SCIENCE

Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

(2009) Yuichi Masuda et al.   CHEMBIOCHEM

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

(2009) W. Mei Kok et al.   CHEMICAL COMMUNICATIONS

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible Protein Kinase C Activator with Bryostatin-like Activity

(2009) Yu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts

(2009) Tapan K. Khan et al.   NEUROBIOLOGY OF DISEASE

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective versus tumorigenic protein kinase C activators

(2009) T.J. Nelson et al.   TRENDS IN BIOCHEMICAL SCIENCES

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals

(2008) Yuichi Masuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Verification of the Intermolecular Parallel β-Sheet in E22K-Aβ42 Aggregates by Solid-State NMR Using Rotational Resonance: Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42

(2008) Yuichi MASUDA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function

(2008) Gary E. Keck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

(2008) Barry M. Trost et al.   NATURE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE