Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer’s Disease Phase IIa and Expanded Access Trials

(2017) Thomas J. Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

(2017) Steven M. Ryckbosch et al.   Nature Communications

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont “Candidatus Endobugula sertula”

(2016) Ian J. Miller et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease

(2016) Stephanie I. Alfonso et al.   Science Signaling

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease

(2016) Stephanie I. Alfonso et al.   Science Signaling

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

SHELXT– Integrated space-group and crystal-structure determination

(2015) George M. Sheldrick   Acta Crystallographica A-Foundation and Advances

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Prins-Type Cyclization Reactions in Natural Product Synthesis

(2013) Xun Han et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A new and more powerfully activating diamine for practical and scalable enantioselective aldehyde crotylsilylation reactions

(2013) Linda M. Suen et al.   Chemical Science

Use of intensity quotients and differences in absolute structure refinement

(2013) Simon Parsons et al.   Acta Crystallographica Section B-Structural Science Crystal Engineering and Materials

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

(2012) Brian A. DeChristopher et al.   Nature Chemistry

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Total Syntheses of Bryostatins: Synthesis of Two Ring-Expanded Bryostatin Analogues and the Development of a New-Generation Strategy to Access the C7-C27 Fragment

(2011) Barry M. Trost et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Bryostatin 9

(2011) Paul A. Wender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Bryostatin 7viaC–C Bond-Forming Hydrogenation

(2011) Yu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bryostatins: biological context and biotechnological prospects

(2010) Amaro E Trindade-Silva et al.   CURRENT OPINION IN BIOTECHNOLOGY

Total Synthesis of Bryostatin 1

(2010) Gary E. Keck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure validation in chemical crystallography

(2009) Anthony L. Spek   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant

(2009) Paul M. Barr et al.   AMERICAN JOURNAL OF HEMATOLOGY

Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells

(2009) S. P. Shaha et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

OLEX2: a complete structure solution, refinement and analysis program

(2009) Oleg V. Dolomanov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Simple One-pot Conversion of Aldehydes and Ketones to Enals

(2009) Petr Valenta et al.   ORGANIC LETTERS

Determination of absolute structure using Bayesian statistics on Bijvoet differences

(2008) Rob W. W. Hooft et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Efficient Synthetic Access to a New Family of Highly Potent Bryostatin Analogues via a Prins-Driven Macrocyclization Strategy

(2008) Paul A. Wender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches

(2008) Barry M. Trost et al.   NATURE

A Metathesis-Based Approach to the Synthesis of 2-Pyridones and Pyridines

(2007) Timothy J. Donohoe et al.   ORGANIC LETTERS