Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Genetics of Frontotemporal Dementia

(2016) Diana A. Olszewska et al.   Current Neurology and Neuroscience Reports

Liquid–liquid phase separation in cellular signaling systems

(2016) P Andrew Chong et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters

(2016) Timothy J. Nott et al.   Nature Chemistry

Tau PET in Alzheimer disease and mild cognitive impairment

(2016) Hanna Cho et al.   NEUROLOGY

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

(2016) Elias Akoury et al.   PROTEIN SCIENCE

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

(2016) Benedetta Bolognesi et al.   Cell Reports

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

Influenza virus mRNA trafficking through host nuclear speckles

(2016) Amir Mor et al.   Nature Microbiology

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition

(2015) Stephanie C. Weber et al.   CURRENT BIOLOGY

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers

(2015) Felipe García Quiroz et al.   NATURE MATERIALS

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy

(2014) Malene Ringkjøbing Jensen et al.   CHEMICAL REVIEWS

Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease

(2014) Laura J Blair et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins

(2014) Xuejun Yao et al.   JOURNAL OF BIOMOLECULAR NMR

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Visualizing the microtubule-associated protein tau in the nucleus

(2014) Jing Lu et al.   Science China-Life Sciences

Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2

(2013) Martin Schwalbe et al.   BIOCHEMISTRY

Aqueous Phase Separation as a Possible Route to Compartmentalization of Biological Molecules

(2012) Christine D. Keating   ACCOUNTS OF CHEMICAL RESEARCH

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies

(2012) T. Vanderweyde et al.   JOURNAL OF NEUROSCIENCE

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

(2012) Cyrille Girard et al.   Nature Communications

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

The Natively Unfolded Character of Tau and Its Aggregation to Alzheimer-like Paired Helical Filaments†

(2008) Sadasivam Jeganathan et al.   BIOCHEMISTRY