The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

(2019) Yingjian You et al.   Acta Neuropathologica Communications

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

(2019) Emily B. Button et al.   Alzheimers Research & Therapy

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

(2019) Balvindar Singh et al.   ACTA NEUROPATHOLOGICA

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

(2019) Lachlan S. Brown et al.   Frontiers in Cellular Neuroscience

Dietary salt promotes cognitive impairment through tau phosphorylation

(2019) Giuseppe Faraco et al.   NATURE

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

(2018) Nina Schultz et al.   AGING CELL

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier

(2018) Shino Magaki et al.   NEUROBIOLOGY OF AGING

Reactive astrocytes in Alzheimer’s disease: A double-edged sword

(2018) Heejung Chun et al.   NEUROSCIENCE RESEARCH

Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease

(2018) Rachel E. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of Extent and Role of Tau in Subcortical Vascular Cognitive Impairment Using 18F-AV1451 Positron Emission Tomography Imaging

(2018) Hee Jin Kim et al.   JAMA Neurology

Targeting pericytes for therapeutic approaches to neurological disorders

(2018) Jinping Cheng et al.   ACTA NEUROPATHOLOGICA

The vascular basement membrane in the healthy and pathological brain

(2017) Maj S Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain perivascular macrophages: characterization and functional roles in health and disease

(2017) Giuseppe Faraco et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Amyloid and intracellular accumulation of BRI 2

(2017) Holly J. Garringer et al.   NEUROBIOLOGY OF AGING

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease

(2017) Sofía Fernández-de Retana et al.   NEUROBIOLOGY OF AGING

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of clusterin in the brain vascular clearance of amyloid-β

(2017) Amy R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies

(2017) Diana L Castillo-Carranza et al.   Aging and Disease

Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy

(2016) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Human cystatin C monomer, dimer, oligomer, and amyloid structures are related to health and disease

(2016) Przemyslaw Jurczak et al.   FEBS LETTERS

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy

(2016) Leslie M. Ramirez et al.   NEUROBIOLOGY OF AGING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Sporadic Cerebral Amyloid Angiopathy: Pathophysiology, Neuroimaging Features, and Clinical Implications

(2016) Gregoire Boulouis et al.   SEMINARS IN NEUROLOGY

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Genes associated with Alzheimer's disease: an overview and current status

(2016) Mohan Giri et al.   Clinical Interventions in Aging

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy

(2015) Nicholas M. Kanaan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model

(2015) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Homozygous carriers of APP A713T mutation in an autosomal dominant Alzheimer disease family

(2015) M. E. Conidi et al.   NEUROLOGY

Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex

(2015) Christoph M. Zehendner et al.   Scientific Reports

Pulse Pressure in Relation to Tau-Mediated Neurodegeneration, Cerebral Amyloidosis, and Progression to Dementia in Very Old Adults

(2015) Daniel A. Nation et al.   JAMA Neurology

Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia

(2015) Jennifer L. Ziskin et al.   Acta Neuropathologica Communications

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

(2015) Laura J Blair et al.   Acta Neuropathologica Communications

Tau Reduction Diminishes Spatial Learning and Memory Deficits after Mild Repetitive Traumatic Brain Injury in Mice

(2015) Jason S. Cheng et al.   PLoS One

Tau reduction prevents disease in a mouse model of Dravet syndrome

(2014) Ania L. Gheyara et al.   ANNALS OF NEUROLOGY

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

The pathologic spectrum of oculoleptomeningeal amyloidosis with Val30Gly transthyretin gene mutation in a postmortem case

(2014) Sarah E. Martin et al.   HUMAN PATHOLOGY

CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings

(2014) L. F. Maia et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

(2014) María S Marcora et al.   Molecular Neurodegeneration

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

(2014) Gary W. Beecham et al.   PLoS Genetics

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Dendritic Spine Density, Morphology, and Fibrillar Actin Content Surrounding Amyloid-β Plaques in a Mouse Model of Amyloid-β Deposition

(2013) Caitlin M. Kirkwood et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy

(2013) Simon Mead et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

(2013) Holly J. Garringer et al.   PLoS One

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

(2012) James P. Solomon et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

A new transthyretin mutation associated with leptomeningeal amyloidosis

(2011) J. J. Liepnieks et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Structural dynamics of the ΔE22 (Osaka) familial Alzheimer’s disease-linked amyloid β-protein

(2011) Mohammed Inayathullah et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Cerebral amyloid angiopathy in the elderly

(2011) Anand Viswanathan et al.   ANNALS OF NEUROLOGY

Cerebral Amyloid Angiopathy: A Systematic Review

(2011) Alessandro Biffi et al.   Journal of Clinical Neurology

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Report of five rare or previously unknown amyloidogenic transthyretin mutations disclosed in Sweden

(2010) Ole B. Suhr et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

Crystal structure of human cystatin C stabilized against amyloid formation

(2010) Robert Kolodziejczyk et al.   FEBS Journal

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques

(2010) S. Kumar-Singh   GENES BRAIN AND BEHAVIOR

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

(2009) Tamas Revesz et al.   ACTA NEUROPATHOLOGICA

Modeling familial British and Danish dementia

(2009) Holly J. Garringer et al.   Brain Structure & Function

Oculoleptomeningeal amyloidosis in 3 individuals with the transthyretin variant Tyr69His

(2009) Kelly Schweitzer et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Hereditary and Sporadic Forms of Aβ-Cerebrovascular Amyloidosis and Relevant Transgenic Mouse Models

(2009) Samir Kumar-Singh   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Perivascular macrophages and cerebral amyloid angiopathy in CRND8 mice

(2009) C. Hawkes et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease

(2009) Shaila P. Handattu et al.   NEUROBIOLOGY OF DISEASE

HIGHLY SELECTIVE LEPTOMENINGEAL AMYLOIDOSIS WITH TRANSTHYRETIN VARIANT ALA25THR

(2009) K. Hagiwara et al.   NEUROLOGY

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

(2009) Roy O Weller et al.   Alzheimers Research & Therapy

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

Cerebral Amyloid Angiopathy and Parenchymal Amyloid Deposition in Transgenic Mice Expressing the Danish Mutant Form of Human BRI2

(2008) Ruben Vidal et al.   BRAIN PATHOLOGY

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-A  Antibody Administration in PDAPP Mice

(2008) J. Koenigsknecht-Talboo et al.   JOURNAL OF NEUROSCIENCE

A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis

(2008) Kazuma Nakagawa et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE