Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

Plasma Gelsolin is Decreased and Correlates with Rate of Decline in Alzheimer's Disease

(2017) Andreas Güntert et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Gelsolin Binds Lipoteichoic Acid and Modulates Cellular Response to Proinflammatory Bacterial Wall Components

(2014) R. Bucki et al.   JOURNAL OF IMMUNOLOGY

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us

(2011) Nina F. Schor   ANNALS OF NEUROLOGY

Heparin Binds 8 kDa Gelsolin Cross-β-Sheet Oligomers and Accelerates Amyloidogenesis by Hastening Fibril Extension

(2011) James P. Solomon et al.   BIOCHEMISTRY

Sulfated Glycosaminoglycans Accelerate Transthyretin Amyloidogenesis by Quaternary Structural Conversion

(2011) Steve Bourgault et al.   BIOCHEMISTRY

1-Palmitoyl-2-(9′-oxononanoyl)-sn-glycero-3-phosphocholine, an Oxidized Phospholipid, Accelerates Finnish Type Familial Gelsolin Amyloidosis in Vitro

(2011) Ajay K. Mahalka et al.   BIOCHEMISTRY

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Targets for AD treatment: conflicting messages from γ-secretase inhibitors

(2011) Kumar Sambamurti et al.   JOURNAL OF NEUROCHEMISTRY

Familial amyloid polyneuropathy

(2011) Violaine Planté-Bordeneuve et al.   LANCET NEUROLOGY

Evidence that  -Secretase-Mediated Notch Signaling Induces Neuronal Cell Death via the Nuclear Factor- B-Bcl-2-Interacting Mediator of Cell Death Pathway in Ischemic Stroke

(2011) T. V. Arumugam et al.   MOLECULAR PHARMACOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

The influence of lacunes on cognitive function

(2011) R. Tripathi et al.   NEUROLOGY

Gelsolin Amyloidosis as a Cause of Early Aging and Progressive Bilateral Facial Paralysis

(2011) Tiia Pihlamaa et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Plasma gelsolin modulates cellular response to sphingosine 1-phosphate

(2010) Robert Bucki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetic aspects of familial amyloidosis with corneal lattice dystrophy and cranial neuropathy

(2010) Jouko Meretoja   CLINICAL GENETICS

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

(2010) Tomás L. Falzone et al.   HUMAN MOLECULAR GENETICS

Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis

(2010) Derrick Sek Tong Ong et al.   Nature Chemical Biology

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

(2010) S. E. Kolstoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lattice corneal dystrophy, gelsolin type (Meretoja’s syndrome)

(2009) Christian Carrwik et al.   ACTA OPHTHALMOLOGICA

The 8 and 5 kDa Fragments of Plasma Gelsolin Form Amyloid Fibrils by a Nucleated Polymerization Mechanism, while the 68 kDa Fragment Is Not Amyloidogenic

(2009) James P. Solomon et al.   BIOCHEMISTRY

Two Prion Variants of Sup35p Have In-Register Parallel β-Sheet Structures, Independent of Hydration

(2009) Frank Shewmaker et al.   BIOCHEMISTRY

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Helix Straightening as an Activation Mechanism in the Gelsolin Superfamily of Actin Regulatory Proteins

(2009) Hui Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Examination of potential mechanisms of amyloid-induced defects in neuronal transport

(2009) Sameer B. Shah et al.   NEUROBIOLOGY OF DISEASE

Familial amyloid polyneuropathy (Finnish type) presenting multiple cranial nerve deficits with carpal tunnel syndrome and orthostatic hypotension

(2009) Kouki Makioka et al.   NEUROLOGICAL RESEARCH

Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein

(2009) Lina Ji et al.   NEUROREPORT

Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

(2009) L. J. Page et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

(2009) S. Nag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of the Thermodynamically Linked Quaternary and Tertiary Structural Stabilities of Transthyretin and Its Disease-Associated Variants: The Relationship between Stability and Amyloidosis†

(2008) Amy R. Hurshman Babbes et al.   BIOCHEMISTRY

Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer’s disease

(2008) Ved Chauhan et al.   BIOGERONTOLOGY

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Plasma Gelsolin: Function, Prognostic Value, and Potential Therapeutic Use

(2008) Robert Bucki et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin

(2008) L.-S. Her et al.   JOURNAL OF NEUROSCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Mechanisms of Protein Fibril Formation: Nucleated Polymerization with Competing Off-Pathway Aggregation

(2007) Evan T. Powers et al.   BIOPHYSICAL JOURNAL