(ADP-ribosyl)hydrolases: structure, function, and biology

The ammonium transporter AmtB and the PII signal transduction protein GlnZ are required to inhibit DraG in Azospirillum brasilense

(2019) V.R. Moure et al.   FEBS Journal

Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation

(2019) Ankan Banerjee et al.   Nature Communications

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

(2019) Nisha Pillay et al.   CANCER CELL

PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders

(2019) Giovanna Grimaldi et al.   BIOCHEMICAL PHARMACOLOGY

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

(2019) Matthew E. Grunewald et al.   PLoS Pathogens

ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP

(2019) Tingting Guo et al.   Nature Microbiology

Targeting ADP-ribosylation as an antimicrobial strategy

(2019) Giuliana Catara et al.   BIOCHEMICAL PHARMACOLOGY

Reversible ADP-ribosylation of RNA

(2019) Deeksha Munnur et al.   NUCLEIC ACIDS RESEARCH

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

(2019) Mathias Bockwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair

(2019) N. I. Rechkunova et al.   BIOCHEMISTRY-MOSCOW

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos

(2019) Nirmal Robinson et al.   Redox Biology

Evaluation of the Antiviral Potential of Halogenated Dihydrorugosaflavonoids and Molecular Modeling with nsP3 Protein of Chikungunya Virus (CHIKV)

(2019) Ninad V. Puranik et al.   ACS Omega

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

(2018) Jian Lei et al.   ANTIVIRAL RESEARCH

Comprehensive ADP‐ribosylome analysis identifies tyrosine as an ADP‐ribose acceptor site

(2018) Deena M Leslie Pedrioli et al.   EMBO REPORTS

Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition

(2018) Yasin Pourfarjam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

(2018) Gabriella Zarkovic et al.   NUCLEIC ACIDS RESEARCH

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

(2018) James A Timmons et al.   NUCLEIC ACIDS RESEARCH

Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer

(2018) Jim Voorneveld et al.   ORGANIC LETTERS

Two-step mechanism and step-arrest mutants of Runella slithyformis NAD+-dependent tRNA 2'-phosphotransferase Tpt1

(2018) Annum Munir et al.   RNA

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis

(2018) Anthony R. Fehr et al.   TRENDS IN MICROBIOLOGY

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

(2018) Anuratha Sakthianandeswaren et al.   Cancer Discovery

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription

(2018) Mareike Bütepage et al.   Scientific Reports

Dna is a New Target of Parp3

(2018) E. A. Belousova et al.   Scientific Reports

Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases

(2018) Anthony K. L. Leung et al.   PLoS Pathogens

Serine is the major residue for ADP-ribosylation upon DNA damage

(2018) Luca Palazzo et al.   eLife

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria

(2018) Thomas Agnew et al.   Frontiers in Microbiology

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

(2018) Ian Carter-O’Connell et al.   ACS Chemical Biology

Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome

(2018) Shereen G. Ghosh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2

(2018) Hidenori Ito et al.   DEVELOPMENTAL NEUROSCIENCE

Structure–function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation

(2018) Mengxi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+-dependent synthesis of a 5′-phospho-ADP-ribosylated RNA/DNA cap by RNA 2′-phosphotransferase Tpt1

(2018) Annum Munir et al.   NUCLEIC ACIDS RESEARCH

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme

(2018) Mario Leutert et al.   Cell Reports

Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation

(2018) Sara C. Larsen et al.   Cell Reports

Interplay of Histone Marks with Serine ADP-Ribosylation

(2018) Edward Bartlett et al.   Cell Reports

Bi-allelic ADPRHL2 Mutations Cause Neurodegeneration with Developmental Delay, Ataxia, and Axonal Neuropathy

(2018) Katharina Danhauser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PARPs in genome stability and signal transduction: implications for cancer therapy

(2018) Luca Palazzo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides

(2018) Bohdan Waszkowycz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation

(2018) Shih-Hsun Chen et al.   NUCLEIC ACIDS RESEARCH

Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice

(2018) Kizuku Watanabe et al.   PLoS One

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

(2018) Rachy Abraham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncovering the Structural Basis of a New Twist in Protein Ubiquitination

(2018) Kedar Puvar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reversible mono-ADP-ribosylation of DNA breaks

(2017) Deeksha Munnur et al.   FEBS Journal

ADP-ribosylation: new facets of an ancient modification

(2017) Luca Palazzo et al.   FEBS Journal

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

(2017) Chun-Song Yang et al.   MOLECULAR CELL

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

The eukaryotic linear motif resource – 2018 update

(2017) Marc Gouw et al.   NUCLEIC ACIDS RESEARCH

A novel non-canonical PIP-box mediates PARG interaction with PCNA

(2017) Tanja Kaufmann et al.   NUCLEIC ACIDS RESEARCH

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

(2017) Robert Lyle McPherson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

(2017) Jeannette Abplanalp et al.   Nature Communications

Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis

(2017) Rubén Zapata-Pérez et al.   Open Biology

Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

(2017) Xiaolei Li et al.   eLife

Serine ADP-ribosylation reversal by the hydrolase ARH3

(2017) Pietro Fontana et al.   eLife

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

(2017)   Molecular Autism

The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases

(2017) Laura Eckei et al.   Scientific Reports

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib

(2016) Dominic I. James et al.   ACS Chemical Biology

Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides

(2016) Hans A. V. Kistemaker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Macrodomains: Structure, Function, Evolution, and Catalytic Activities

(2016) Johannes Gregor Matthias Rack et al.   Annual Review of Biochemistry

TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors

(2016) C. Bindesboll et al.   BIOCHEMICAL JOURNAL

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

Functional Role of ADP-Ribosyl-Acceptor Hydrolase 3 in poly(ADPRibose) Polymerase-1 Response to Oxidative Stress

(2016) Masato Mashimo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

New Insights into the Roles of NAD+-Poly(ADP-ribose) Metabolism and Poly(ADP-ribose) Glycohydrolase

(2016) Sei-ichi Tanuma et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly

(2016) Stuart J. Smith et al.   DEVELOPMENTAL BIOLOGY

ENPP1 processes protein ADP-ribosylationin vitro

(2016) Luca Palazzo et al.   FEBS Journal

New directions in poly(ADP-ribose) polymerase biology

(2016) Florian J. Bock et al.   FEBS Journal

Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production inStreptomyces coelicolor

(2016) Jasna Lalić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair

(2016) Alasdair R. Gunn et al.   JOURNAL OF CELL SCIENCE

Viral Macro Domains Reverse Protein ADP-Ribosylation

(2016) Changqing Li et al.   JOURNAL OF VIROLOGY

The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA

(2016) Gytis Jankevicius et al.   MOLECULAR CELL

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

(2016) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Serine is a new target residue for endogenous ADP-ribosylation on histones

(2016) Orsolya Leidecker et al.   Nature Chemical Biology

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

ATM induces MacroD2 nuclear export upon DNA damage

(2016) Barbara Golia et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragmentsin vitro

(2016) Ibtissam Talhaoui et al.   NUCLEIC ACIDS RESEARCH

CATH: an expanded resource to predict protein function through structure and sequence

(2016) Natalie L. Dawson et al.   NUCLEIC ACIDS RESEARCH

Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus

(2016) C. Denise Appel et al.   PROTEIN SCIENCE

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

(2016) Anthony R. Fehr et al.   mBio

Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain

(2016) Teemu Haikarainen et al.   Scientific Reports

Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach

(2016) Ian Carter-O’Connell et al.   Cell Reports

Processing of protein ADP-ribosylation by Nudix hydrolases

(2015) Luca Palazzo et al.   BIOCHEMICAL JOURNAL

Structural insights into the mechanism of Escherichia coli YmdB: A 2′- O -acetyl-ADP-ribose deacetylase

(2015) Weichang Zhang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Synthesis of Dimeric ADP-Ribose and Its Structure with Human Poly(ADP-ribose) Glycohydrolase

(2015) Michael J. Lambrecht et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens

(2015) Johannes Gregor Matthias Rack et al.   MOLECULAR CELL

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation

(2015) Eva Barkauskaite et al.   MOLECULAR CELL

An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks

(2015) Zhiqiang Wu et al.   NUCLEIC ACIDS RESEARCH

Effects of DNA3′pp5′G capping on 3′ end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance

(2015) Mathieu Chauleau et al.   NUCLEIC ACIDS RESEARCH

Combined computational and experimental analysis of a complex of ribonuclease III and the regulatory macrodomain protein, YmdB

(2015) Samridhdi Paudyal et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Arabidopsis PARG1 is the key factor promoting cell survival among the enzymes regulating post-translational poly(ADP-ribosyl)ation

(2015) Hailei Zhang et al.   Scientific Reports

From Structure-Function Analyses to Protein Engineering for Practical Applications of DNA Ligase

(2015) Maiko Tanabe et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Mutations of the functional ARH1 allele in tumors from ARH1 heterozygous mice and cells affect ARH1 catalytic activity, cell proliferation and tumorigenesis

(2015) J Kato et al.   Oncogenesis

ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses

(2014) Gaia Fabrizio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases

(2014) Masato Mashimo et al.   DNA REPAIR

Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism

(2014) Toni I. Gossmann et al.   DNA REPAIR

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life

(2014) Dragutin Perina et al.   DNA REPAIR

PARP12, an Interferon-stimulated Gene Involved in the Control of Protein Translation and Inflammation

(2014) Iain Welsby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly(ADP-Ribosyl) Glycohydrolase Prevents the Accumulation of Unusual Replication Structures during Unperturbed S Phase

(2014) Arnab Ray Chaudhuri et al.   MOLECULAR AND CELLULAR BIOLOGY

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

(2014) Giuditta Illuzzi et al.   NUCLEIC ACIDS RESEARCH

Demonstration of Cytotoxicity against Wasps by Pierisin-1: A Possible Defense Factor in the Cabbage White Butterfly

(2014) Azusa Takahashi-Nakaguchi et al.   PLoS One

MACROD2overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

(2014) Morassa Mohseni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts

(2014) Matthew D. Daugherty et al.   PLoS Genetics

Escherichia coli YmdB regulates biofilm formation independently of its role as an RNase III modulator

(2013) Taeyeon Kim et al.   BMC MICROBIOLOGY

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation

(2013) Karla LH Feijs et al.   Cell Communication and Signaling

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

ADP-ribosylation, a mechanism regulating nitrogenase activity

(2013) Stefan Nordlund et al.   FEBS Journal

NAD and ADP-ribose metabolism in mitochondria

(2013) Christian Dölle et al.   FEBS Journal

Identification of LRP16 as a Negative Regulator of Insulin Action and Adipogenesis in 3T3-L1 Adipocytes

(2013) L. Zang et al.   HORMONE AND METABOLIC RESEARCH

Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication

(2013) S. Atasheva et al.   JOURNAL OF VIROLOGY

Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning

(2013) Hila Sberro et al.   MOLECULAR CELL

Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome

(2013) Yajie Zhang et al.   NATURE METHODS

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases

(2013) Florian Rosenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation

(2013) Gytis Jankevicius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

(2013) M. Mashimo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

(2013) Eva Barkauskaite et al.   Nature Communications

Diversity and roles of (t)RNA ligases

(2012) Johannes Popow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sirtuins: NAD+-dependent deacetylase mechanism and regulation

(2012) Anthony A Sauve et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

ADP-ribosylhydrolase 3 (ARH3), Not Poly(ADP-ribose) Glycohydrolase (PARG) Isoforms, Is Responsible for Degradation of Mitochondrial Matrix-associated Poly(ADP-ribose)

(2012) Marc Niere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New PARP Gene with an Anti-Alphavirus Function

(2012) S. Atasheva et al.   JOURNAL OF VIROLOGY

Influence of the ADP/ATP ratio, 2-oxoglutarate and divalent ions on Azospirillum brasilense PII protein signalling

(2012) E. C. M. Gerhardt et al.   MICROBIOLOGY-SGM

Identification of novel components of NAD-utilizing metabolic pathways and prediction of their biochemical functions

(2012) Robson Francisco de Souza et al.   Molecular BioSystems

Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element

(2012) In-Kwon Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

(2012) Julie A. Tucker et al.   PLoS One

ADP-ribosylation of guanosine by SCO5461 protein secreted from Streptomyces coelicolor

(2012) Tsuyoshi Nakano et al.   TOXICON

Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase

(2012) Mark S. Dunstan et al.   Nature Communications

ADP-Ribosylarginine Hydrolase Regulates Cell Proliferation and Tumorigenesis

(2011) J. Kato et al.   CANCER RESEARCH

Orphan Macrodomain Protein (Human C6orf130) Is anO-Acyl-ADP-ribose Deacylase

(2011) Francis C. Peterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Macrodomain Proteins as NovelO-Acetyl-ADP-ribose Deacetylases

(2011) Dawei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrolysis ofO-Acetyl-ADP-ribose Isomers by ADP-ribosylhydrolase 3

(2011) Atsushi Kasamatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PII signal transduction proteins: pivotal players in post-translational control of nitrogenase activity

(2011) L. F. Huergo et al.   MICROBIOLOGY-SGM

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

(2011) Dea Slade et al.   NATURE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

(2011) Oliver Mortusewicz et al.   NUCLEIC ACIDS RESEARCH

LRP16 Integrates into NF-κB Transcriptional Complex and Is Required for Its Functional Activation

(2011) Zhiqiang Wu et al.   PLoS One

Crystal structure of the GlnZ-DraG complex reveals a different form of PII-target interaction

(2011) C. Rajendran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis

(2010) W. Min et al.   CARCINOGENESIS

A genome-wide scan for common alleles affecting risk for autism

(2010) R. Anney et al.   HUMAN MOLECULAR GENETICS

Sensing NAD metabolites through macro domains

(2009) Susanne Till   Frontiers in Bioscience-Landmark

Crystal Structure of Dinitrogenase Reductase-activating Glycohydrolase (DRAG) Reveals Conservation in the ADP-Ribosylhydrolase Fold and Specific Features in the ADP-Ribose-binding Pocket

(2009) Xiao-Dan Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG

(2009) C. L. Berthold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

DNA and RNA ligases: structural variations and shared mechanisms

(2008) John M Pascal   CURRENT OPINION IN STRUCTURAL BIOLOGY

The single-macro domain protein LRP16 is an essential cofactor of androgen receptor

(2008) J Yang et al.   ENDOCRINE-RELATED CANCER

YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity

(2008) K.-s. Kim et al.   GENES & DEVELOPMENT