Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks

(2015) Zhiqiang Wu et al.   NUCLEIC ACIDS RESEARCH

The impact of PKR activation: from neurodegeneration to cancer

(2014) Juan A. Marchal et al.   FASEB JOURNAL

Whole-exome sequencing of endometriosis identifies frequent alterations in genes involved in cell adhesion and chromatin-remodeling complexes

(2014) Xiaolei Li et al.   HUMAN MOLECULAR GENETICS

Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice

(2014) Katharina Martina Janice Syhr et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells

(2013) X. Liu et al.   BLOOD

Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma

(2013) X Li et al.   BRITISH JOURNAL OF CANCER

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

(2013) Christopher J Lord et al.   NATURE MEDICINE

Drug rechallenge and treatment beyond progression—implications for drug resistance

(2013) Elizabeth A. Kuczynski et al.   Nature Reviews Clinical Oncology

DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out

(2012) Kevin W. McCool et al.   IMMUNOLOGICAL REVIEWS

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma

(2012) N Kunkeaw et al.   ONCOGENE

The macro domain protein family: Structure, functions, and their potential therapeutic implications

(2011) Weidong Han et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Hierarchies of NF-κB target-gene regulation

(2011) Stephen T Smale   NATURE IMMUNOLOGY

LRP16 Integrates into NF-κB Transcriptional Complex and Is Required for Its Functional Activation

(2011) Zhiqiang Wu et al.   PLoS One

The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53- Independent Manner in Colon and Breast Cancer Cells

(2011) María Angel García et al.   PLoS One

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death

(2010) P Peidis et al.   CELL DEATH AND DIFFERENTIATION

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

Susceptibility Pathways in Fanconi's Anemia and Breast Cancer

(2010) Alan D. D'Andrea   NEW ENGLAND JOURNAL OF MEDICINE

Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma

(2010) Hong-Qing Xi   WORLD JOURNAL OF GASTROENTEROLOGY

The nuclear signaling of NF-κB: current knowledge, new insights and future perspectives

(2009) Fengyi Wan et al.   CELL RESEARCH

Constitutive NF- B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth

(2009) K. Sakamoto et al.   CLINICAL CANCER RESEARCH

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

(2009) Michael Stilmann et al.   MOLECULAR CELL

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

(2009) C.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Platinum Resistance: The Role of DNA Repair Pathways

(2008) L. P. Martin et al.   CLINICAL CANCER RESEARCH

The single-macro domain protein LRP16 is an essential cofactor of androgen receptor

(2008) J Yang et al.   ENDOCRINE-RELATED CANCER