Hydrogen sulfide signaling in mitochondria and disease

LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages

(2019) Leema George et al.   IMMUNOLOGICAL INVESTIGATIONS

Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement

(2019) Mengting Xu et al.   EXPERIMENTAL DERMATOLOGY

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

(2019) Marouane Libiad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome c Reduction by H2S Potentiates Sulfide Signaling

(2018) Victor Vitvitsky et al.   ACS Chemical Biology

Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae

(2018) ANDREW T. MERAM et al.   ANTICANCER RESEARCH

Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction

(2018) Jing Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

The regulation of tumor cell physiology by mitochondrial dynamics

(2018) David F. Kashatus   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A review of hydrogen sulfide (H 2 S) donors: Chemistry and potential therapeutic applications

(2018) Chadwick R. Powell et al.   BIOCHEMICAL PHARMACOLOGY

Gasotransmitter hydrogen sulfide signaling in neuronal health and disease

(2018) Bindu D. Paul et al.   BIOCHEMICAL PHARMACOLOGY

Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: Implications for the pathogenesis and treatment of diabetes mellitus

(2018) Jerzy Bełtowski et al.   BIOCHEMICAL PHARMACOLOGY

A timeline of hydrogen sulfide (H 2 S) research: From environmental toxin to biological mediator

(2018) Csaba Szabo   BIOCHEMICAL PHARMACOLOGY

Drug resistance induces the upregulation of H 2 S-producing enzymes in HCT116 colon cancer cells

(2018) Ashley A. Untereiner et al.   BIOCHEMICAL PHARMACOLOGY

Multiple role of 3-mercaptopyruvate sulfurtransferase: antioxidative function, H2 S and polysulfide production and possible SOx production

(2018) Noriyuki Nagahara   BRITISH JOURNAL OF PHARMACOLOGY

Regulators of the Transsulfuration Pathway

(2018) Juan I Sbodio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer

(2018) Prabir Kumar Chakraborty et al.   FASEB JOURNAL

Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes

(2018) Rajesh Parsanathan et al.   FREE RADICAL RESEARCH

Beyond the tip of the iceberg; a new view of the diversity of sulfite- and sulfate-reducing microorganisms

(2018) Adrien Vigneron et al.   ISME Journal

Allosteric control of human cystathionine β-synthase activity by a redox active disulfide bond

(2018) Weining Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK

(2018) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endogenous H 2 S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice

(2018) Changnan Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion

(2018) László Potor et al.   Oxidative Medicine and Cellular Longevity

Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology

(2018) Alessandro Giuffrè et al.   Oxidative Medicine and Cellular Longevity

Hydrogen sulfide mediates athero-protection against oxidative stress via S-sulfhydration

(2018) Sau Ha Cheung et al.   PLoS One

Soluble Oligomers of Amyloid-β Cause Changes in Redox State, DNA Methylation, and Gene Transcription by Inhibiting EAAT3 Mediated Cysteine Uptake

(2018) Nathaniel Hodgson et al.   JOURNAL OF ALZHEIMERS DISEASE

Cystathione β-Synthase Is Increased in Thyroid Malignancies

(2018) ELBA A. TURBAT-HERRERA et al.   ANTICANCER RESEARCH

Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum

(2018) Leonardo de Moura Alvorcem et al.   MITOCHONDRION

Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner

(2018) Jingyao Zhang et al.   Oxidative Medicine and Cellular Longevity

Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling

(2017) Danyang Tian et al.   FREE RADICAL BIOLOGY AND MEDICINE

A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin

(2017) Markus Ruetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate

(2017) Ning Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Distinctive expression pattern of cystathionine-β-synthase and cystathionine-γ-lyase identifies mesenchymal stromal cells transition to mineralizing osteoblasts

(2017) Laura Gambari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cystathionine β-synthase deficiency: Of mice and men

(2017) Warren D. Kruger   MOLECULAR GENETICS AND METABOLISM

Hydrogen sulfide inhibits mitochondrial fission in neuroblastoma N2a cells through the Drp1/ERK1/2 signaling pathway

(2017) Peifeng Qiao et al.   Molecular Medicine Reports

Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats

(2017) Wei-lan Yin et al.   NEUROSCIENCE LETTERS

A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionineβ-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?

(2017) João B. Vicente et al.   Oxidative Medicine and Cellular Longevity

Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress

(2017) Wei Zou et al.   Oncotarget

H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes

(2017) Shyam Sundar Nandi et al.   Scientific Reports

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels

(2016) Jay S. Naik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery

(2016) Maggie M. Kuo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Development of sulfanegen for mass cyanide casualties

(2016) Steven E. Patterson et al.   Annals of the New York Academy of Sciences

Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms

(2016) Ashley A. Untereiner et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages

(2016) Lei Miao et al.   ANTIOXIDANTS & REDOX SIGNALING

H2S biosynthesis and catabolism: new insights from molecular studies

(2016) Peter Rose et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Regulators of mitochondrial dynamics in cancer

(2016) Daniela Senft et al.   CURRENT OPINION IN CELL BIOLOGY

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration

(2016) Sounik Saha et al.   FASEB JOURNAL

ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment

(2016) Zachary C. Wright et al.   HUMAN MOLECULAR GENETICS

Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse

(2016) A Badiei et al.   JOURNAL OF BIOSCIENCES

Hydrogen Sulfide Oxidation by Myoglobin

(2016) Trever Bostelaar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Hydrogen Sulfide in the Adipose Tissue—Physiology, Pathology and a Target for Pharmacotherapy

(2016) Jerzy Bełtowski et al.   MOLECULES

Biological consilience of hydrogen sulfide and nitric oxide in plants: Gases of primordial earth linking plant, microbial and animal physiologies

(2016) Hideo Yamasaki et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Stimulatory effect of CSE-generated H2S on hepatic mitochondrial biogenesis and the underlying mechanisms

(2016) Ashley A. Untereiner et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion

(2016) Nozomu Takahashi et al.   NUCLEIC ACIDS RESEARCH

Hydrogen Sulfide and Cellular Redox Homeostasis

(2016) Zhi-Zhong Xie et al.   Oxidative Medicine and Cellular Longevity

AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

(2016) Feng-li Zhao et al.   Oxidative Medicine and Cellular Longevity

Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse

(2016) Xuan-li He et al.   Pharmacological Reports

The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

(2016) Domokos Gerő et al.   PHARMACOLOGICAL RESEARCH

S- Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

(2016) Katalin Módis et al.   PHARMACOLOGICAL RESEARCH

Both the H 2 S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H 2 S donor AP39 exert protective effects in a mouse model of burn injury

(2016) Akbar Ahmad et al.   PHARMACOLOGICAL RESEARCH

Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2

(2016) Yuangui Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Transcriptional control of amino acid homeostasis is disrupted in Huntington’s disease

(2016) Juan I. Sbodio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo

(2016) Akbar Ahmad et al.   SHOCK

Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

(2016) Rudolf Wedmann et al.   Chemical Science

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

(2016) E. Doka et al.   Science Advances

Urothelium muscarinic activation phosphorylates CBSSer227 via cGMP/PKG pathway causing human bladder relaxation through H2S production

(2016) Roberta d’Emmanuele di Villa Bianca et al.   Scientific Reports

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

(2016) Bartosz Szczesny et al.   Scientific Reports

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

(2015) Barbara Renga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Evidence of hydrogen sulfide involvement in amyotrophic lateral sclerosis

(2015) Alessandro Davoli et al.   ANNALS OF NEUROLOGY

Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM

(2015) Shuangshuang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer

(2015) Mark R. Hellmich et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Glutathionylation Enhances Human Cystathionine β-Synthase Activity Under Oxidative Stress Conditions

(2015) Wei-Ning Niu et al.   ANTIOXIDANTS & REDOX SIGNALING

Signaling Molecules: Hydrogen Sulfide and Polysulfide

(2015) Hideo Kimura   ANTIOXIDANTS & REDOX SIGNALING

Cystathionine  -synthase-derived hydrogen sulfide is involved in human malignant hyperthermia

(2015) V. Vellecco et al.   CLINICAL SCIENCE

Role of cystathionine β-synthase in human breast Cancer

(2015) Suvajit Sen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulfide Oxidation by a Noncanonical Pathway in Red Blood Cells Generates Thiosulfate and Polysulfides

(2015) Victor Vitvitsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2015) Pauline Snijder et al.   MOLECULAR MEDICINE

Neuronal regulation of expression of hydrogen sulfide-producing enzyme cystathionine β-synthase in rat spinal cord astrocytes

(2015) Ryo Miyamoto et al.   NEUROSCIENCE RESEARCH

Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice

(2015) Kohei Ikeda et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Down-regulated CBS/H2S pathway is involved in high-salt-induced hypertension in Dahl rats

(2015) Pan Huang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury

(2015) Dongdong Wu et al.   Oxidative Medicine and Cellular Longevity

Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt

(2015) Yanfang Zong et al.   Oxidative Medicine and Cellular Longevity

Hydrogen sulfide and cardioprotection — Mechanistic insights and clinical translatability

(2015) Fadi N. Salloum   PHARMACOLOGY & THERAPEUTICS

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer

(2015) Prabir K Chakraborty et al.   Oncotarget

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases

(2014) Guoliang Meng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration

(2014) Yi Liu et al.   Cell Stem Cell

Nuclear receptors rock around the clock

(2014) X. Zhao et al.   EMBO REPORTS

Protective and biogenesis effects of sodium hydrosulfide on brain mitochondria after cardiac arrest and resuscitation

(2014) Hao Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hydrogen Sulfide Represses Androgen Receptor Transactivation by Targeting at the Second Zinc Finger Module

(2014) Kexin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and Interaction Studies of Two Isoforms of the Dual Localized 3-Mercaptopyruvate Sulfurtransferase TUM1 from Humans

(2014) Benjamin Fräsdorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers

(2014) Bao Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen sulfide activation in hemeproteins: The sulfheme scenario

(2014) Bessie B. Ríos-González et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Hydrogen Sulfide Upregulates Glutamate–Cysteine Ligase Catalytic Subunit, Glutamate–Cysteine Ligase Modifier Subunit, and Glutathione and Inhibits Interleukin-1β Secretion in Monocytes Exposed to High Glucose Levels

(2014) Sushil K. Jain et al.   Metabolic Syndrome and Related Disorders

Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function

(2014) YING-HUA XIE et al.   Molecular Medicine Reports

Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression

(2014) MIN LV et al.   Molecular Medicine Reports

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Working with “H2S”: Facts and apparent artifacts

(2014) Rudolf Wedmann et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

(2014) Bartosz Szczesny et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Effect of S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

(2014) Katalin Módis et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Exogenous hydrogen sulfide causes different hemodynamic effects in normotensive and hypertensive rats via neurogenic mechanisms

(2014) Mariusz Sikora et al.   Pharmacological Reports

Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases

(2014) Tomas Majtan et al.   PLoS One

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen sulphide and tempol treatments improve the blood pressure and renal excretory responses in spontaneously hypertensive rats

(2014) Fiaz ud din Ahmad et al.   RENAL FAILURE

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Persulfide Reactivity in the Detection of Protein S-Sulfhydration

(2013) Jia Pan et al.   ACS Chemical Biology

Detection of Protein S-Sulfhydration by a Tag-Switch Technique

(2013) Dehui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polysulfides Link H2S to Protein Thiol Oxidation

(2013) Romy Greiner et al.   ANTIOXIDANTS & REDOX SIGNALING

Enzymology of H2S Biogenesis, Decay and Signaling

(2013) Omer Kabil et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin 1 Is Essential for Sodium Sulfide–Mediated Cardioprotection in the Setting of Heart Failure

(2013) Chad K. Nicholson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sulfide inhibition of and metabolism by cytochromecoxidase

(2013) Peter Nicholls et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

(2013) Antonia Asimakopoulou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Polysulfides are possible H2S-derived signaling molecules in rat brain

(2013) Yuka Kimura et al.   FASEB JOURNAL

Microbial regulation of host hydrogen sulfide bioavailability and metabolism

(2013) Xinggui Shen et al.   FREE RADICAL BIOLOGY AND MEDICINE

PGC-1α, mitochondrial dysfunction, and Huntington's disease

(2013) Ashu Johri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase

(2013) Pramod Kumar Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Control of S-Nitrosothiol Reactivity: Interplay of Antagonistic Resonance Structures

(2013) Marat R. Talipov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protective effects of hydrogen sulfide in a rat model of traumatic brain injury via activation of mitochondrial adenosine triphosphate–sensitive potassium channels and reduction of oxidative stress

(2013) Xiaofan Jiang et al.   JOURNAL OF SURGICAL RESEARCH

Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress

(2013) Ya-Dan Wen et al.   PLoS One

Increase or Decrease Hydrogen Sulfide Exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese Mice

(2013) Bin Geng et al.   PLoS One

Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

(2013) Sanjib Bhattacharyya et al.   PLoS One

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

High Turnover Rates for Hydrogen Sulfide Allow for Rapid Regulation of Its Tissue Concentrations

(2012) Victor Vitvitsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Platelet-derived growth factor-BB induces cystathionine γ-lyase expression in rat mesangial cells via a redox-dependent mechanism

(2012) Mohamed I. Hassan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells

(2012) G. Tang et al.   DIABETOLOGIA

Hydrogen Sulfide Impairs Glucose Utilization and Increases Gluconeogenesis in Hepatocytes

(2012) Ling Zhang et al.   ENDOCRINOLOGY

Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

(2012) Katalin Módis et al.   FASEB JOURNAL

Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols

(2012) Milos R. Filipovic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

Solubility and Permeation of Hydrogen Sulfide in Lipid Membranes

(2012) Ernesto Cuevasanta et al.   PLoS One

Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

(2012) M. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interdependency of Cystathione  -Lyase and Cystathione  -Synthase in Hydrogen Sulfide-Induced Blood Pressure Regulation in Rats

(2011) A. Roy et al.   AMERICAN JOURNAL OF HYPERTENSION

Passive loss of hydrogen sulfide in biological experiments

(2011) Eric R. DeLeon et al.   ANALYTICAL BIOCHEMISTRY

Thioredoxin Interacting Protein: Redox Dependent and Independent Regulatory Mechanisms

(2011) Oded N. Spindel et al.   ANTIOXIDANTS & REDOX SIGNALING

The reaction of H2S with oxidized thiols: Generation of persulfides and implications to H2S biology

(2011) Nestor E. Francoleon et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biochemical insight into physiological effects of H2S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite

(2011) Milos R. Filipovic et al.   BIOCHEMICAL JOURNAL

Reversible Heme-Dependent Regulation of Human Cystathionine β-Synthase by a Flavoprotein Oxidoreductase

(2011) Omer Kabil et al.   BIOCHEMISTRY

Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

(2011) Asif K. Mustafa et al.   CIRCULATION RESEARCH

Rat pancreatic level of cystathionine γ-lyase is regulated by glucose level via specificity protein 1 (SP1) phosphorylation

(2011) L. Zhang et al.   DIABETOLOGIA

Hydrogen sulfide inhibits macrophage-derived foam cell formation

(2011) Zhan-Zhi Zhao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Specificity Protein-1 as a Critical Regulator of Human Cystathionine γ-Lyase in Smooth Muscle Cells

(2011) Guangdong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

(2011) K. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress

(2010) Shawn E. Bearden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhaled Hydrogen Sulfide Prevents Neurodegeneration and Movement Disorder in a Mouse Model of Parkinson's Disease

(2010) Kotaro Kida et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries

(2010) Ruth Pietri et al.   ANTIOXIDANTS & REDOX SIGNALING

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

(2010) Andrew P. Halestrap   BIOCHEMICAL SOCIETY TRANSACTIONS

Hydrogen sulphide protects mouse pancreatic β-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress

(2010) S Taniguchi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rapid Reaction of Hydrogen Sulfide with the Neutrophil Oxidant Hypochlorous Acid to Generate Polysulfides

(2010) Péter Nagy et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

(2009) Li-Fang Hu et al.   AGING CELL

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL

(2009) Markus K. Muellner et al.   BIOCHEMICAL JOURNAL

Nitroxyl (HNO) signaling

(2009) Jon M. Fukuto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions

(2009) Sangita Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gases in the mitochondria

(2009) Pamela B.L. Pun et al.   MITOCHONDRION

Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide

(2009) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation

(2009) James P. Collman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling by Gasotransmitters

(2009) A. K. Mustafa et al.   Science Signaling

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

(2009) Barbara Renga et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling

(2008) Saurabh Jha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

(2008) Julie Furne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

(2008) Norihiro Shibuya et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulfide : quinone oxidoreductase (SQR) from the lugworm Arenicola marina shows cyanide- and thioredoxin-dependent activity

(2008) Ursula Theissen et al.   FEBS Journal

Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose

(2008) Yukiko Kaneko et al.   FEBS LETTERS

Hydrogen sulfide protects astrocytes against H2O2-induced neural injury via enhancing glutamate uptake

(2008) Ming Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Supression of hemin-mediated oxidation of low-density lipoprotein and subsequent endothelial reactions by hydrogen sulfide (H2S)

(2008) Viktória Jeney et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

(2008) Xia ZHAO et al.   HYPERTENSION RESEARCH

Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S

(2008) Qingxiang Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H2S-induced pancreatic acinar cell apoptosis is mediatedviaJNK and p38 MAP kinase

(2008) Sharmila Adhikari et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats

(2008) Lingyun Wu et al.   LABORATORY INVESTIGATION

Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction

(2008) Pinpat Tripatara et al.   LABORATORY INVESTIGATION

The ecology and biotechnology of sulphate-reducing bacteria

(2008) Gerard Muyzer et al.   NATURE REVIEWS MICROBIOLOGY

Human Polycomb 2 Protein Is a SUMO E3 Ligase and Alleviates Substrate-Induced Inhibition of Cystathionine β-Synthase Sumoylation

(2008) Nitish Agrawal et al.   PLoS One