Article
Biochemistry & Molecular Biology
Musubu Takahashi, Tomoya Fujie, Tsuyoshi Nakano, Takato Hara, Yasuhiro Shinkai, Ryoko Takasawa, Yasushi Hara, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji
Summary: TGF-beta(1) can increase intracellular RSS levels to modulate its inhibitory effect on proliferation. The induction of RSS-producing enzymes, likely through the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways, is responsible for the increased production of high-molecular-mass RSS, which may play a role in modulating regulatory activities in vascular endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Virender Kumar Pal, Ragini Agrawal, Srabanti Rakshit, Pooja Shekar, Diwakar Tumkur Narasimha Murthy, Annapurna Vyakarnam, Amit Singh
Summary: This study reveals the unexpected role of hydrogen sulfide (H2S) in HIV latency and reactivation, showing that downregulation of CTH and reduction in endogenous H2S are associated with HIV reactivation. Chemical complementation of CTH activity using H2S donor GYY4137 suppresses HIV reactivation by inducing the Keap1-Nrf2 pathway and inhibiting NF-kappa B, providing mechanistic insight into H2S-mediated suppression of viral rebound.
Article
Oncology
Yanqiong Liu, Qiulian Wu, Fuyong Zhang, Xue Qin
Summary: This study provides evidence for the first time that the NRF2 gene rs6721961 variation is a potential genetic marker for susceptibility to hepatocellular carcinoma (HCC).
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Wenting Jian, Huigai Ma, Dingming Wang, Peng Yang, Mengbi Jiang, Yu Zhong, Xiang Long, Jingjing Jiang, Yuan Gong
Summary: This study demonstrates that omaveloxolone exerts significant cardioprotective effects in treating sepsis-induced cardiomyopathy by activating the Nrf2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shuang Zhao, Tianyu Song, Yue Gu, Yihua Zhang, Siyi Cao, Qing Miao, Xiyue Zhang, Hongshan Chen, Yuanqing Gao, Lei Zhang, Yi Han, Hong Wang, Jun Pu, Liping Xie, Yong Ji
Summary: The study suggests that H2S alleviates liver damage by activating Keap1 S-sulfhydration and promoting the activation of Nrf2, leading to increased expression of antioxidant proteins, which may have potential therapeutic benefits for liver diseases.
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Cell Biology
David Rysanek, Pavla Vasicova, Jayaprakash Narayana Kolla, David Sedlak, Ladislav Andera, Jiri Bartek, Zdenek Hodny
Summary: The accumulation of senescent cells in aging tissues contributes to age-associated diseases. Inhibiting the anti-apoptotic machinery of senescent cells through BCL-2 protein family inhibitors can eliminate these cells. Combination therapy with BCL-2 inhibitors shows synergistic effects in eliminating senescent cells and overcoming resistance to monotherapy.
Article
Environmental Sciences
Yuan-yuan Wei, Hui-ru Wang, Yi-meng Fan, Jin-hua Gu, Xiu-ying Zhang, Xu-hao Gong, Zhi-hui Hao
Summary: The study evaluated the effect and underlying mechanism of GDK aqueous extract in alleviating acute liver injury caused by CCl4. The results showed that GDK effectively inhibited liver damage and restored the structure and function of the liver. It achieved this by suppressing liver fibrosis, blocking the NFicB pathway, inhibiting hepatic inflammatory response, reducing oxidative stress, inhibiting ferroptosis, and alleviating hepatocyte injury caused by CCl4. In conclusion, this study provides insights into the potential complex mechanism of GDK against acute liver injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li
Summary: This study found that 15, 16-Dihydrotanshinone I (DHT) can protect against ferroptosis and ischemic stroke by activating the Nrf2 signaling pathway.
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Huiyan Deng, Miaojian Wan, Huaping Li, Quan Chen, Runxiang Li, Bihua Liang, Huilan Zhu
Summary: The study demonstrates that curcumin can protect the skin from UV damage by regulating the Nrf2 pathway. UV irradiation leads to cell apoptosis and oxidative stress, which can be reversed by adding curcumin. Additionally, curcumin induces Nrf2 nuclear accumulation in Hacat cells to provide protection against UV exposure-induced photodamage.
Article
Biochemistry & Molecular Biology
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike
Summary: Reactive sulfur species, such as cysteine hydropersulfide and glutathione persulfide, are produced abundantly in both prokaryotes and eukaryotes, including mammals. Cysteinyl-tRNA synthetase (CARS) has been identified as a new cysteine persulfide synthase (CPERS) responsible for the production of most reactive persulfides. However, the contribution of other enzymes, such as 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine beta-synthase (CBS), and cystathionine gamma-lyase (CSE), to reactive persulfide production is still debated. In this study, the authors used sulfur metabolome analysis to demonstrate that 3-MST, CBS, and CSE are not major sources of reactive persulfides in mammals, and CARS/CPERS is the principal enzyme involved.
Article
Oncology
Zhuoying Lin, Wenjie Huang, Qin He, Dongxiao Li, Zhihui Wang, Yangyang Feng, Danfei Liu, Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian, Limin Xia
Summary: In summary, our study reveals that the positive feedback loop of ROS-FOXC1-cysteine metabolism-ROS is crucial for promoting liver cancer proliferation and metastasis, suggesting a potential clinical treatment approach for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Clinical Neurology
Xin-Jiang Yan, Cheng-Peng Zhan, Yao Lv, Dan-Dan Mao, Ri-Cheng Zhou, Yong-Min Xv, Guo-Feng Yu
Summary: This study found that increased serum Nrf2 levels in severe traumatic brain injury (sTBI) patients are associated with traumatic severity and prognosis. Serum Nrf2 levels may serve as an important prognostic marker for sTBI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
Summary: Propofol can reduce myocardial I/R injury by activating PKC/NRF2 pathway, leading to increased antioxidant enzyme expression and decreased levels of lactate dehydrogenase and creatine kinase-MB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Muhammad Hassan, Mohammad Ali Sadiq, Maria Soledad Ormaechea, Gunay Uludag, Muhammad Sohail Halim, Rubbia Afridi, Diana Do, Yasir Jamal Sepah, Quan Dong Nguyen
Summary: Intravenous tocilizumab showed efficacy in improving or maintaining stability in patients with non-infectious uveitis when assessed using a composite endpoint scoring system.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Computer Science, Hardware & Architecture
Md Golam Rabiul Alam, Abde Musavvir Khan, Myesha Farid Shejuty, Syed Ibna Zubayear, Md Nafis Shariar, Meteb Altaf, Mohammad Mehedi Hassan, Salman A. AlQahtani, Ahmed Alsanad
Summary: This paper proposes an automated Ejection Fraction estimation system from 2D echocardiography images using deep semantic segmentation neural networks. Two parallel pipelines of deep semantic segmentation neural network models have been proposed for efficient left ventricle segmentation, and three different neural networks, UNet, ResUNet, and Deep ResUNet, have been implemented. The most accurate model achieved high Dice scores for left ventricle segmentation in both systolic and diastolic states. The proposed system can remove the eyeball estimation practice and reduce inter-observer variability.
JOURNAL OF SUPERCOMPUTING
(2023)
Article
Computer Science, Information Systems
Muhammad Umair Hassan, Dongmei Niu, Mingxuan Zhang, Xiuyang Zhao
Summary: This research proposes a novel asymmetric learning-based generative adversarial network (AGAN) for image retrieval, integrating feature learning with hashing and introducing three loss functions that significantly improve retrieval performance.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Editorial Material
Cell Biology
Eric Delpire, Thomas J. Hawke, Mythreye Karthikeyan, Wei Kong, Alexander Nystroem, Shizuka Uchida, Liliana Schaefer
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cell Biology
Malgorzata Wygrecka, Ioannis Alexopoulos, Daniel P. Potaczek, Liliana Schaefer
Summary: ApoA-I plays an important role in reverse cholesterol transport and also possesses anti-inflammatory and antioxidative functions. Dysfunctional apoA-I or its low abundance can lead to the formation of foam cells in alveolar macrophages. Increased numbers of foam cells have been observed in the lungs of mice exposed to certain substances and in patients with lung fibrosis. Understanding the role of apoA-I in lung fibrosis provides potential avenues for therapeutic development.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Engineering, Civil
Kashif Naseer Qureshi, Gwanggil Jeon, Mohammad Mehedi Hassan, Md. Rafiul Hassan, Kuljeet Kaur
Summary: Intelligent Transportation Systems (ITS) have gained popularity due to their smart services, but the increasing number of users has raised concerns over data processing, storage, security, and privacy. To address these concerns, this paper proposes a Blockchain-based Privacy-Preserving Authentication (BPPAU) model that uses smart contracts, access control policies, and on-demand functions to manage data while maintaining user privacy. The model's performance is evaluated through simulation tests analyzing transaction cost, transaction per second, and computational time with various data sizes and block times.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Jia Hu, Kuljeet Kaur, Hui Lin, Xiaoding Wang, Mohammad Mehedi Hassan, Imran Razzak, Mohammad Hammoudeh
Summary: This paper proposes a Transfer Learning based Trajectory Anomaly Detection strategy, named TLTAD, for IoT-empowered Maritime Transportation Systems (IoT-MTS). Experimental results show that TLTAD can accurately detect anomalies in ships' trajectories and reduce model training time.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Civil
Peng Xu, Ke Wang, Mohammad Mehedi Hassan, Chien-Ming Chen, Weiguo Lin, Md Rafiul Hassan, Giancarlo Fortino
Summary: This paper employs a One-Shot Neural Architecture Search (NAS) to generate derivative models with different scales and studies the relationship between network sizes and model robustness. The experimental results show that reducing model parameters can increase model robustness under maximum adversarial attacks, while increasing model parameters can enhance model robustness under minimum adversarial attacks. This analysis helps to understand the adversarial robustness of models with different scales for edge AI transportation systems.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Review
Cell Biology
Sarah Miethe, Daniel P. Potaczek, Stanislawa Bazan-Socha, Melanie Bachl, Liliana Schaefer, Malgorzata Wygrecka, Holger Garn
Summary: Extracellular vesicles (EVs) have gained attention for their role in intercellular signaling, particularly in the connection between adipose tissue (AT) and the lung in diseases such as obesity-associated asthma and lung cancer-associated cachexia. Studies have shown both pathogenic and protective effects of EVs in these diseases, with AT-derived EVs playing a potential therapeutic role. Further research is needed to better understand the role of EVs in disease development and organ interconnectivity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shivani Batra, Shagufta Jahan, Anam Ashraf, Bandar Alharby, Talha Jawaid, Asimul Islam, Imtaiyaz Hassan
Summary: Cyclin-dependent kinase 5 (CDK5) is a serine/threonine-directed kinase primarily found in the brain that plays a crucial role in the development of the central nervous system. Recent research has shown that CDK5 is activated by specific cyclins, which regulate its expression and activity. This review examines the role of CDK5 in neurons, synaptic plasticity, DNA damage repair, and the cell cycle, highlighting its therapeutic potential as a target for neurodegenerative diseases. The structural features of CDK5 and its binding with designed inhibitors are also discussed, providing insights for the development of attractive strategies in therapeutic targeting.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Ashar Rais, Afzal Husain, Gulam Mustafa Hasan, Md. Imtaiyaz Hassan
Summary: The extracellular matrix (ECM) is a complex network that helps cells aggregate and form functional structures. It plays multiple roles in tissue structure and function, beyond its initial passive functions. The discovery of cellular receptors and their interaction with ECM components has opened new avenues for understanding the role of ECM in developmental programs, wound healing, and tumour progression. This review focuses on how ECM influences the progression of the somatic cell cycle and provides molecular insights into the communication between adhesion complex, signaling pathways, and cell cycle machinery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Tufail Ali, Farah Anjum, Arunabh Choudhury, Alaa Shafie, Amal Adnan Ashour, Abdulraheem Almalki, Taj Mohammad, Md. Imtaiyaz Hassan
Summary: Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that plays a crucial role in signal transduction in different cell types. In this study, two natural compounds, Isolysergic acid and Michelanugine, were identified as potential SYK inhibitors with strong affinity and specificity for the SYK binding pocket. These compounds have the potential to be developed into promising SYK inhibitors for the treatment of autoimmune disorders, cancer, and inflammatory diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Pallabi Banerjee, Anshuman Chandra, Taj Mohammad, Nagendra Singh, Md. Imtaiyaz Hassan, Imteyaz Qamar
Summary: This study identified six potential inhibitors that can selectively interrupt the binding of PDXK with its substrate PLP, stabilizing the structure of PDXK. The findings provide valuable information for designing specific and effective PDXK inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Manzar Alam, Sarfraz Ahmed, Mohammad Abid, Gulam Mustafa Hasan, Asimul Islam, Md. Imtaiyaz Hassan
Summary: Microtubule affinity-regulating kinase 4 (MARK4) is a crucial protein kinase involved in the development of cancer and neurodegenerative diseases. It modulates various signaling pathways and has potential as a drug target for cancer, diabetes, and Alzheimer's. However, there is limited knowledge on its structure, function, and clinical significance. This review provides detailed information on MARK4's structure, role in signaling pathways, and therapeutic potential as well as updates on its research, which will aid in the development of effective therapeutic molecules.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Engineering, Environmental
Amina Ashraf, Ruba Munir, Gadah Albasher, Madiha Ghamkhar, Amna Muneer, Muhammad Yaseen, Tamsal Murtza, Saima Noreen
Summary: In this study, ZnFe2O4 nanocomposites were successfully synthesized and used for dye removal from aqueous solutions. The results showed that pH, adsorbent dosage, contact time, and initial concentration of dyes had an effect on the adsorption performance. The nanocomposites were found to be reusable to some extent.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
