Review
Multidisciplinary Sciences
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin
Summary: H2S plays a crucial role in glucose metabolism by affecting insulin secretion, apoptosis of islet β cells, insulin sensitivity, glucose uptake, adipogenesis, lipolysis, and modulation of circadian-clock genes. Further studies are needed to determine whether H2S could be a promising target for diabetes mellitus treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laura Micheli, Emma Mitidieri, Carlotta Turnaturi, Domenico Vanacore, Clara Ciampi, Elena Lucarini, Giuseppe Cirino, Carla Ghelardini, Raffaella Sorrentino, Lorenzo Di Cesare Mannelli, Roberta D'Emmanuele di Villa Bianca
Summary: In an in vitro model of sarcopenia, impairment in CBS/CSE/H2S signaling occurs, and glucoraphanin, as a natural H2S-releasing molecule, appears to be more effective in preventing muscle damage. Therefore, glucoraphanin supplementation could be an innovative therapeutic approach in the management of sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yingying Wang, Xiang Ni, Rahuljeet Chadha, Caitlin McCartney, Yannie Lam, Brock Brummett, Geat Ramush, Ming Xian
Summary: Hydrogen sulfide (H2S) plays critical roles in redox biology, and its imbalance can lead to pathological processes. Recent advances in inhibitors and scavengers for H2S have been made, but challenges remain, including potency and specificity of inhibitors, as well as biologically active by-products produced during scavenging. Further development is needed for potent and specific inhibitors, as well as scavengers that generate biocompatible by-products for potential therapeutic applications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Rong-Hsuan Wang, Yu-Hsin Chu, Kai-Ti Lin
Summary: Hydrogen sulfide, while important for physiological functions, is also associated with aberrant expression in cancer development; understanding the roles of tumor-derived H2S in cancer provides opportunities for targeted therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rodney E. Shackelford, Yan Li, Ghali E. Ghali, Christopher G. Kevil
Summary: Hydrogen sulfide (H2S) plays a significant role in DNA repair by modulating cell cycle checkpoints, DNA damage response, and genomic stability. DNA repair proteins are influenced by cellular H2S concentrations and sulfur metabolism.
Article
Biochemistry & Molecular Biology
Viktor Kozich, Bernd C. Schwahn, Jitka Sokolova, Michaela Krizkova, Tamas Ditroi, Jakub Krijt, Youssef Khalil, Tomas Krizek, Tereza Vaculikova-Fantlova, Blanka Stiburkova, Philippa Mills, Peter Clayton, Kristyna Barvikova, Holger Blessing, Jolanta Sykut-Cegielska, Carlo Dionisi-Vici, Serena Gasperini, Angeles Garcia-Cazorla, Tobias B. Haack, Tomas Honzik, Pavel Jesina, Alice Kuster, Lucia Laugwitz, Diego Martinelli, Francesco Porta, Rene Santer, Guenter Schwarz, Peter Nagy
Summary: Regulation of H2S homeostasis in humans is not well understood. By studying patients with genetic defects, the importance of certain enzymes in H2S synthesis and catabolism was assessed. The findings suggest the presence of control and compensatory mechanisms in the maintenance of H2S homeostasis.
Article
Biochemistry & Molecular Biology
Dandan Zhang, Xiuqin Hong, Jia Wang, Yu Jiang, Ying Zhang, Jian Chen, Xiaona Niu
Summary: The study demonstrates that estrogen can play a protective role in patients with hyperhomocysteinemia and hypertension, which is associated with Hcy metabolism and endogenous hydrogen sulfide production. Estrogen reverses the expression of enzymes responsible for H2S production in endothelial cells treated with Hcy, indicating its potential therapeutic effects.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maria Romerowicz-Misielak, Katarzyna Koziol, Slawomir Nowak, Marek Koziorowski
Summary: Circadian clock genes play a crucial role in regulating rhythmic processes within cells and disruptions in their functioning are associated with various disorders. H2S has been identified as a key regulator of the circadian rhythm. Pharmacological inhibition of CBS and CSE affects the expression of the Per2 gene, with exposure to AOAA potentially influenced by factors other than CBS and CSE activity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Endocrinology & Metabolism
Saul Huerta de la Cruz, Erick J. Rodriguez-Palma, Cindy L. Santiago-Castaneda, Jesus H. Beltran-Ornelas, Araceli Sanchez-Lopez, Luisa Rocha, David Centurion
Summary: This study aimed to evaluate the effect of NaHS subchronic treatment on the changes of H2S-synthesizing enzymes in the hypothalamus and brainstem after TBI. The results showed that NaHS had an effect on CBS and CSE protein expression, suggesting a potential role in the impairments observed after TBI.
METABOLIC BRAIN DISEASE
(2022)
Article
Microbiology
Olga Martzoukou, Panayiotis D. Glekas, Margaritis Avgeris, Diomi Mamma, Andreas Scorilas, Dimitris Kekos, Sotiris Amillis, Dimitris G. Hatzinikolaou
Summary: In this study, researchers performed precise genome editing on the model biocatalyst Rhodococcus qingshengii IGTS8 for the first time, shedding light on the regulation of dsz gene expression and biocatalyst activity dependent on the presence of two reverse transsulfuration enzymes, C beta S and MetB. Additionally, they observed an enhancement of biodesulfurization capability in the presence of otherwise repressive sulfur sources like sulfate and L-methionine. The interconnection of cellular sulfur assimilation strategies was revealed and validated.
Article
Cell Biology
Giulia Pozzi, Giuliana Gobbi, Elena Masselli, Cecilia Carubbi, Valentina Presta, Luca Ambrosini, Marco Vitale, Prisco Mirandola
Summary: T cell-mediated adaptive immunity responds to non-self antigens and pathogens by activating and proliferating various T cell populations, with hydrogen sulfide playing a crucial regulatory role in this process.
Review
Biochemistry & Molecular Biology
Moussa Omorou, Ning Liu, Yiwei Huang, Hisham Al-Ward, Meng Gao, Chenxi Mu, Lin Zhang, Xu Hui
Summary: In this article, the role and mechanism of Cystathionine beta-Synthase (CBS) during hypoxia and ischemia/reperfusion (I/R) processes in various tissues are reviewed. CBS regulates hydrogen sulfide generation and homocysteine metabolism to interact with other molecules and repair the concerned tissues. However, the effects of CBS can be both protective and pathological, depending on the organism, tissue, or subcellular localization. Artificially controlling CBS expression may provide new strategies for the treatment or prevention of hypoxia and I/R-related injury.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Cell Biology
Lihua Gong, Xiaoqi Sun, Ming Zhang, Junbao Du, Yi Ding, Hongfang Jin
Summary: Decreased expression of CSE in osteosarcoma and its metastasis may suggest its role in osteoblast cell malignant transformation and osteosarcoma progression. These enzymes could be used as new prognostic assessment factors and therapeutic targets for osteosarcoma and metastasis prevention.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Medicine, General & Internal
Nicole Denoix, Oscar McCook, Angelika Scheuerle, Thomas Kapapa, Andrea Hoffmann, Harald Guendel, Christiane Waller, Csaba Szabo, Peter Radermacher, Tamara Merz
Summary: This study investigated the effects of systemic H2S administration on the brain using neuro-histopathology and immunohistochemistry analysis. The results showed that Na2S2O3 could not penetrate the blood brain barrier in the hypothalamic PVN region, indicating no therapeutic effects in this area.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Ya-Qing Han, Zi-Bo Zhang, Kun Wang, Guang-Jie Liu, Shao-Nan Xie, Qing-Yi Liu, Fang Liu
Summary: The study investigated the expression of cystathionine beta-synthase (CBS) in lung squamous cell carcinoma (LUSC) and its correlation with microvascular density (MVD) and clinicopathological features. The results showed that CBS was overexpressed in tumor tissues, including LUSC, and its expression was associated with tumor stages, differentiation degrees, and MVD. Survival analysis indicated that high CBS expression was associated with poor prognosis. CBS expression, T stages, and TNM stages were identified as independent factors affecting the prognosis of LUSC. The findings suggest that CBS could serve as a biomarker for prognosis evaluation and potential target for LUSC treatment.
Review
Clinical Neurology
Klaudia Sapko, Anna Jamroz-Wisniewska, Michal Marciniec, Marcin Kulczynski, Anna Szczepanska-Szerej, Konrad Rejdak
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2020)
Article
Cell Biology
Anna Jamroz-Wisniewska, Jerzy Beltowski, Grazyna Wojcicka, Halina Bartosik-Psujek, Konrad Rejdak
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
Jolanta Parada-Turska, Grazyna Wojcicka, Jerzy Beltowski
Article
Medicine, General & Internal
Anna Jamroz-Wisniewska, Radoslaw Zajdel, Agnieszka Slowik, Monika Marona, Marcin Wnuk, Monika Adamczyk-Sowa, Bozena Adamczyk, Anetta Lasek-Bal, Przemyslaw Puz, Arkadiusz Steposz, Ewa Krzystanek, Maja Patalong-Ogiewa, Anna Pokryszko-Dragan, Slawomir Budrewicz, Dorota Koziarska, Anna Karbicka, Slawomir Wawrzyniak, Waldemar Fryze, Marzena Furtak-Niczyporuk, Konrad Rejdak
Summary: The study found that the NEDA-3 rate after the first year of therapy was higher for natalizumab compared to fingolimod. Patients with lower MRS on platform therapy had better outcomes when switching to second-line therapy. Early switching to second-line therapy may lead to better results for patients treated with natalizumab or fingolimod.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Klaudia Sapko, Anna Jamroz-Wisniewska, Anna Wozniak, Michal Marciniec, Marcin Kulczynski, Marzena Janczarek, Robert Rejdak, Konrad Rejdak
Summary: This case report describes a patient with Susac syndrome (SuS) who was diagnosed based on the clinical picture and test results. Despite treatment, the disease continued to progress. The importance of considering SuS as a potential cause for hearing loss or encephalopathy of unknown etiology is emphasized.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Anna K. Szewczyk, Anna Jamroz-Wisniewska, Natalia Haratym, Konrad Rejdak
Summary: Neuropathic pain and chronic pain are interdisciplinary problems that involve medicine, psychology, sociology, and economics. The scale of this problem is increasing due to population aging and the growing incidence of lifestyle disorders. Occupational populations may also be affected by these diseases, impacting their quality of life, mental health, and work productivity. Proper assessment is crucial for determining the best treatment method.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2022)
Article
Neurosciences
Anna Drelich-Zbroja, Anna Jamroz-Wisniewska, Maryla Kuczynska, Monika Zbroja, Weronika Cyranka, Katarzyna Drelich, Olga Pustelniak, Izabela Dabrowska, Katarzyna Markiewicz
Summary: The study found that the fully online study mode had a negative impact on the mental health of students during the COVID-19 pandemic, while hybrid students were more likely to use active and positive coping strategies. This suggests that implementing systemic psychological care is crucial in dealing with the significant psychological effects of the pandemic in the coming years.
Editorial Material
Cardiac & Cardiovascular Systems
Jerzy Beltowski
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
Article
Immunology
Agata Czarnowska, Joanna Tarasiuk, Olga Zajkowska, Marcin Wnuk, Monika Marona, Klaudia Nowak, Agnieszka Slowik, Anna Jamroz-Wisniewska, Konrad Rejdak, Beata Lech, Malgorzata Popiel, Iwona Rosciszewska-Zukowska, Adam Perenc, Halina Bartosik-Psujek, Mariola Swiderek-Matysiak, Malgorzata Siger, Agnieszka Ciach, Agata Walczak, Anna Jurewicz, Mariusz Stasiolek, Karolina Kania, Klara Dyczkowska, Alicja Kalinowska-Lyszczarz, Weronika Galus, Anna Walawska-Hrycek, Ewa Krzystanek, Justyna Chojdak-Lukasiewicz, Jakub Ubysz, Anna Pokryszko-Dragan, Katarzyna Kapica-Topczewska, Marcin Bazylewicz, Anna Mironczuk, Joanna Kulikowska, Jan Kochanowicz, Marta Bialek, Malgorzata Stolarz, Katarzyna Kubicka-Baczyk, Natalia Niedziela, Natalia Morawiec, Monika Adamczyk-Sowa, Aleksandra Podlecka-Pietowska, Monika Nojszewska, Beata Zakrzewska-Pniewska, Elzbieta Jasinska, Jacek Zaborski, Marta Milewska-Jedrzejczak, Jacek Zwiernik, Beata Zwiernik, Andrzej Potemkowski, Waldemar Brola, Alina Kulakowska
Summary: Vaccination against SARS-CoV-2 is safe for people with MS who are being treated with DMTs. Most adverse events following vaccination are mild and the acute relapse incidence is low.
Article
Biochemistry & Molecular Biology
Jolanta Kowalczyk-Boltuc, Krzysztof Wiorkowski, Jerzy Beltowski
Summary: This study investigated the effects of hydrogen sulfide (H2S) and inorganic polysulfides on insulin sensitivity in adipose tissue. The results suggest that polysulfides may normalize insulin sensitivity, at least in the adipose tissue, in obesity/metabolic syndrome.
Article
Clinical Neurology
Agata Czarnowska, Joanna Tarasiuk, Olga Zajkowska, Marcin Wnuk, Monika Marona, Klaudia Nowak, Agnieszka Slowik, Anna Jamroz-Wisniewska, Konrad Rejdak, Beata Lech, Malgorzata Popiel, Iwona Rosciszewska-Zukowska, Adam Perenc, Halina Bartosik-Psujek, Mariola Swiderek-Matysiak, Malgorzata Siger, Agnieszka Ciach, Agata Walczak, Anna Jurewicz, Mariusz Stasiolek, Karolina Kania, Klara Dyczkowska, Alicja Kalinowska-Lyszczarz, Weronika Galus, Anna Walawska-Hrycek, Ewa Krzystanek, Justyna Chojdak-Lukasiewicz, Jakub Ubysz, Anna Pokryszko-Dragan, Katarzyna Kapica-Topczewska, Monika Chorazy, Marcin Bazylewicz, Anna Mironczuk, Joanna Kulikowska, Jan Kochanowicz, Marta Bialek, Malgorzata Stolarz, Katarzyna Kubicka-Baczyk, Natalia Niedziela, Pawel Warmus, Monika Adamczyk-Sowa, Aleksandra Podlecka-Pictowska, Monika Nojszewska, Beata Zakrzewska-Pniewska, Elzbieta Jasinska, Jacek Zaborski, Marta Milewska-Jedrzejczak, Jacek Zwiernik, Beata Zwiernik, Andrzej Potemkowski, Waldemar Brola, Alina Kulakowska
Summary: This study evaluated the side effects of COVID-19 vaccination among patients with multiple sclerosis (MS) treated with disease-modifying therapies (DMTs). The results showed that vaccination is safe and can help reduce hesitancy towards vaccination among MS patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Klaudia Sapko, Anna Jamroz-Wisniewska, Konrad Rejdak
Summary: Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. The pathogenesis of progressive MS (PMS) is complex and causes therapeutic difficulties. The efficacy of currently available anti-inflammatory drugs for PMS is limited in time. In search of innovative solutions, several research studies have evaluated the effectiveness of drugs with neuroprotective or remyelinating effects in PMS. This review discusses the compounds that have entered the clinical assessment phase and explores future prospects for successful PMS treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Peripheral Vascular Disease
Jerzy Beltowski
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Review
Health Care Sciences & Services
Anna K. Szewczyk, Urszula Skrobas, Anna Jamroz-Wisniewska, Krystyna Mitosek-Szewczyk, Konrad Rejdak
Summary: Since the outbreak of the new coronavirus, some patients have experienced neurological issues such as bilateral facial nerve palsy and progressive ascending paresis of the limbs, but most cases have favorable outcomes. Symptoms of nerve damage related to COVID-19 may be linked to facial nerve damage, highlighting the importance of studying the virus's impact on the nervous system.
Article
Medicine, General & Internal
Anna K. Szewczyk, Anna Jamroz-Wisniewska, Konrad Rejdak
Summary: This study found a high incidence of peripheral neuropathy in middle-aged individuals, with a slightly higher prevalence in women than men. The occurrence of pain was correlated with disease progression/severity in subacute type and small fiber neuropathy.
MEDICINA-LITHUANIA
(2021)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)