Bioengineering virus-like particles as vaccines

Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

(2013) Yap P. Chuan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Developments in virus-like particle-based vaccines for HIV

(2013) Luigi Buonaguro et al.   Expert Review of Vaccines

Hepatitis B core–based virus–like particles to present heterologous epitopes

(2013) Kenny Roose et al.   Expert Review of Vaccines

Virus-like particles produced in plants as potential vaccines

(2013) Nunzia Scotti et al.   Expert Review of Vaccines

SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier

(2013) Masaaki Kawano et al.   Expert Review of Vaccines

Insect cells as a production platform of complex virus-like particles

(2013) Fabiana Fernandes et al.   Expert Review of Vaccines

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

(2013) Peter Pushko et al.   INTERVIROLOGY

Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations

(2013) Lin Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Virus-like particle formulation optimization by miniaturized high-throughput screening

(2013) Johannes Mohr et al.   METHODS

Design of Hybrid Lipid/Retroviral-Like Particle Gene Delivery Vectors

(2013) Rahul K. Keswani et al.   MOLECULAR PHARMACEUTICS

Conformational and Thermal Stability Improvements for the Large-Scale Production of Yeast-Derived Rabbit Hemorrhagic Disease Virus-Like Particles as Multipurpose Vaccine

(2013) Erlinda Fernández et al.   PLoS One

M2e-Displaying Virus-Like Particles with Associated RNA Promote T Helper 1 Type Adaptive Immunity against Influenza A

(2013) Lorena Itatí Ibañez et al.   PLoS One

Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle

(2013) Melisa R. Anggraeni et al.   VACCINE

Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice

(2013) Hao-Yang Li et al.   VACCINE

Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS)

(2013) Tania Rivera-Hernandez et al.   VACCINE

Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

(2013) Stefan W. Metz et al.   PLoS Neglected Tropical Diseases

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

(2013) Claudine Porta et al.   PLoS Pathogens

Osmolyte-Mediated Encapsulation of Proteins inside MS2 Viral Capsids

(2012) Jeff E. Glasgow et al.   ACS Nano

High-yield and scalable cell-free assembly of virus-like particles by dilution

(2012) Mervyn W.O. Liew et al.   BIOCHEMICAL ENGINEERING JOURNAL

Modular engineering of a microbially-produced viral capsomere vaccine for influenza

(2012) Nani Wibowo et al.   CHEMICAL ENGINEERING SCIENCE

Virus-like particles as universal influenza vaccines

(2012) Sang-Moo Kang et al.   Expert Review of Vaccines

A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection

(2012) Brendan M. Giles et al.   JOURNAL OF INFECTIOUS DISEASES

Investigation of a predicted N-terminal amphipathic α-helix using atomistic molecular dynamics simulation of a complete prototype poliovirus virion

(2012) Jason A. Roberts et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Nanosystem Self-Assembly Pathways Discovered via All-Atom Multiscale Analysis

(2012) Stephen D. Pankavich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Virus-Like Particle That Elicits Cross-Reactive Antibodies to the Conserved Stem of Influenza Virus Hemagglutinin

(2012) A. Schneemann et al.   JOURNAL OF VIROLOGY

Expression of Chikungunya Virus-like Particles

(2012) R. A. Velez et al.   MICROSCOPY AND MICROANALYSIS

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

Disassembly and reassembly improves morphology and thermal stability of human papillomavirus type 16 virus-like particles

(2012) Qinjian Zhao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hepatitis E vaccine debuts

(2012) Soo Bin Park   NATURE

Toolbox for Non-Intrusive Structural and Functional Analysis of Recombinant VLP Based Vaccines: A Case Study with Hepatitis B Vaccine

(2012) Anke M. Mulder et al.   PLoS One

Computer-aided antibody design

(2012) D. Kuroda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles

(2012) Yu-Li Lin et al.   VACCINE

Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development

(2012) Natasha Kushnir et al.   VACCINE

Stability studies of HIV-1 Pr55gag virus-like particles made in insect cells after storage in various formulation media

(2012) Alisson Lynch et al.   Virology Journal

Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity

(2012) Qinjian Zhao et al.   Virology Journal

On the Effect of Thermodynamic Equilibrium on the Assembly Efficiency of Complex Multi-Layered Virus-Like Particles (VLP): the Case of Rotavirus VLP

(2012) António Roldão et al.   PLoS Computational Biology

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles

(2011) Carlee E. Ashley et al.   ACS Nano

Genetically Programmed In Vivo Packaging of Protein Cargo and Its Controlled Release from Bacteriophage P22

(2011) Alison O'Neil et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptide-Controlled Access to the Interior Surface of Empty Virus Nanoparticles

(2011) Frank Sainsbury  et al.   CHEMBIOCHEM

Antibody Breadth and Protective Efficacy Are Increased by Vaccination with Computationally Optimized Hemagglutinin but Not with Polyvalent Hemagglutinin-Based H5N1 Virus-Like Particle Vaccines

(2011) Brendan M. Giles et al.   Clinical and Vaccine Immunology

Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

(2011) Marine L. B. Hillaire et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Efficient disulfide bond formation in virus-like particles

(2011) Bradley C. Bundy et al.   JOURNAL OF BIOTECHNOLOGY

Advances in Virus-Like Particle Vaccines for Filoviruses

(2011) Kelly L. Warfield et al.   JOURNAL OF INFECTIOUS DISEASES

Biophysical Characterization and Conformational Stability of Ebola and Marburg Virus-Like Particles

(2011) Lei Hu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Multidimensional methods for the formulation of biopharmaceuticals and vaccines

(2011) Nathaniel R. Maddux et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Atomic Force Microscopy in Imaging of Viruses and Virus-Infected Cells

(2011) Y. G. Kuznetsov et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Potato Virus Y-Like Particles as a New Carrier for the Presentation of Foreign Protein Stretches

(2011) Ieva Kalnciema et al.   MOLECULAR BIOTECHNOLOGY

Defying malaria: Arming T cells to halt malaria

(2011) Michael F Good et al.   NATURE MEDICINE

Vaccine Potential of Nipah Virus-Like Particles

(2011) Pramila Walpita et al.   PLoS One

Murine Polyomavirus Virus-Like Particles Carrying Full-Length Human PSA Protect BALB/c Mice from Outgrowth of a PSA Expressing Tumor

(2011) Mathilda Eriksson et al.   PLoS One

Capsomer Vaccines Protect Mice from Vaginal Challenge with Human Papillomavirus

(2011) Wai-Hong Wu et al.   PLoS One

Protein delivery using engineered virus-like particles

(2011) S. J. Kaczmarczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiscale simulation of microbe structure and dynamics

(2011) Harshad Joshi et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A molecular dynamics study of loop fluctuation in human papillomavirus type 16 virus-like particles: A possible indicator of immunogenicity

(2011) Harshad Joshi et al.   VACCINE

Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV

(2011) Ye V. Liu et al.   VACCINE

A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets

(2011) Brendan M. Giles et al.   VACCINE

A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines

(2011) Anton P.J. Middelberg et al.   VACCINE

Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine

(2011) Lissette S. Velasquez et al.   VACCINE

Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes

(2011) Peter Pushko et al.   VACCINE

RNA-Directed Packaging of Enzymes within Virus-like Particles

(2010) Jason D. Fiedler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoscale topography of hepatitis B antigen particles by atomic force microscopy

(2010) Pierre-Emmanuel Milhiet et al.   BIOCHIMIE

Modeling the competition between aggregation and self-assembly during virus-like particle processing

(2010) Yong Ding et al.   BIOTECHNOLOGY AND BIOENGINEERING

Generation of a tumor vaccine candidate based on conjugation of a MUC1 peptide to polyionic papillomavirus virus-like particles

(2010) Sharmila Pejawar-Gaddy et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Low pH-Triggered Model Drug Molecule Release from Virus-Like Particles

(2010) Noriko Ohtake et al.   CHEMBIOCHEM

Separation and quantification of double- and triple-layered rotavirus-like particles by CZE

(2010) Ricardo M. Castro-Acosta et al.   ELECTROPHORESIS

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

A Lentiviral Strategy for Highly Efficient Retrograde Gene Transfer by Pseudotyping with Fusion Envelope Glycoprotein

(2010) Shigeki Kato et al.   HUMAN GENE THERAPY

Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens inCervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

(2010) Michel Deschuyteneer et al.   Human vaccines & immunotherapeutics

Microbial production of virus-like particle vaccine protein at gram-per-litre levels

(2010) Mervyn W.O. Liew et al.   JOURNAL OF BIOTECHNOLOGY

Antigenic Characteristics of Rhinovirus Chimeras Designed in silico for En5hanced Presentation of HIV-1 gp41 Epitopes

(2010) Mauro Lapelosa et al.   JOURNAL OF MOLECULAR BIOLOGY

H1N1 Influenza Virus-Like Particles: Physical Degradation Pathways and Identification of Stabilizers

(2010) Julian Kissmann et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Assembly and Immunological Properties of Newcastle Disease Virus-Like Particles Containing the Respiratory Syncytial Virus F and G Proteins

(2010) L. W. McGinnes et al.   JOURNAL OF VIROLOGY

Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial

(2010) Feng-Cai Zhu et al.   LANCET

Protein transduction from retroviral Gag precursors

(2010) Christine Voelkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient production of phosphorylated hepatitis B core particles in yeast Pichia pastoris

(2010) Janis Freivalds et al.   PROTEIN EXPRESSION AND PURIFICATION

Production and purification of human papillomavirus type 33 L1 virus-like particles from Spodoptera frugiperda 9 cells using two-step column chromatography

(2010) Jin-Oh Baek et al.   PROTEIN EXPRESSION AND PURIFICATION

Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection

(2010) Subhashini Jagu et al.   VACCINE

Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design

(2010) Emily M. Plummer et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Challenges for the production of virus-like particles in insect cells: The case of rotavirus-like particles

(2009) Laura A. Palomares et al.   BIOCHEMICAL ENGINEERING JOURNAL

Viral structural transition mechanisms revealed by multiscale molecular dynamics/order parameter extrapolation simulation

(2009) Yinglong Miao et al.   BIOPOLYMERS

Molecular Dynamics as a Tool in Rational Drug Design: Current Status and Some Major Applications

(2009) Roberta Galeazzi   Current Computer-Aided Drug Design

Use of hepadnavirus core proteins as vaccine platforms

(2009) David C Whitacre et al.   Expert Review of Vaccines

Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes

(2009) Lorena E Brown et al.   IMMUNOLOGY AND CELL BIOLOGY

Affinity purification of viral protein having heterogeneous quaternary structure: Modeling the impact of soluble aggregates on chromatographic performance

(2009) Daniel I. Lipin et al.   JOURNAL OF CHROMATOGRAPHY A

Cutting Edge: Limited Specialization of Dendritic Cell Subsets for MHC Class II-Associated Presentation of Viral Particles

(2009) Susanne A. Keller et al.   JOURNAL OF IMMUNOLOGY

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Phase Diagram of Self-assembled Viral Capsid Protein Polymorphs†

(2009) L. Lavelle et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Controlled Encapsulation of Multiple Proteins in Virus Capsids

(2009) Inge J. Minten et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres

(2009) Y. P. Chuan et al.   Journal of the Royal Society Interface

Newcastle Disease Virus-Like Particles Containing Respiratory Syncytial Virus G Protein Induced Protection in BALB/c Mice, with No Evidence of Immunopathology

(2009) M. R. Murawski et al.   JOURNAL OF VIROLOGY

Analysis of Modified Human Papillomavirus Type 16 L1 Capsomeres: the Ability To Assemble into Larger Particles Correlates with Higher Immunogenicity

(2009) L. Schadlich et al.   JOURNAL OF VIROLOGY

Biological Gene Delivery Vehicles: Beyond Viral Vectors

(2009) Yiqi Seow et al.   MOLECULAR THERAPY

Strategies for recruiting and targeting dendritic cells for optimizing HIV vaccines

(2009) Jeffrey D. Ahlers et al.   TRENDS IN MOLECULAR MEDICINE

Efficient generation of cowpea mosaicvirus empty virus-like particles by the proteolytic processing of precursors in insect cells and plants

(2009) Keith Saunders et al.   VIROLOGY

Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres

(2009) Yoshihiko Murata et al.   Virology Journal

Characterization of virus-like particle assembly for DNA delivery using asymmetrical flow field-flow fractionation and light scattering

(2008) Andrzej Citkowicz et al.   ANALYTICAL BIOCHEMISTRY

Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particles

(2008) D. I. Lipin et al.   ARCHIVES OF VIROLOGY

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY

Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy

(2008) Leonard F. Pease et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rational Design of a Stable, Freeze-Dried Virus-Like Particle-Based Vaccine Formulation

(2008) R. Lang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with the minor capsid proteins VP2/3

(2008) Takamasa Inoue et al.   JOURNAL OF BIOTECHNOLOGY

Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering

(2008) Daniel I. Lipin et al.   JOURNAL OF CHROMATOGRAPHY A

In Silico Vaccine Design Based on Molecular Simulations of Rhinovirus Chimeras Presenting HIV-1 gp41 Epitopes

(2008) Mauro Lapelosa et al.   JOURNAL OF MOLECULAR BIOLOGY

Physical Stabilization of Norwalk Virus‐Like Particles**The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

(2008) Julian Kissmann et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Direct Comparison of Human Papillomavirus Type 16 L1 Particles Reveals a Lower Immunogenicity of Capsomeres than Viruslike Particles with Respect to the Induced Antibody Response

(2008) N. Thones et al.   JOURNAL OF VIROLOGY

VIPERdb2: an enhanced and web API enabled relational database for structural virology

(2008) M. Carrillo-Tripp et al.   NUCLEIC ACIDS RESEARCH

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge

(2008) Yao-Chi Chung et al.   VACCINE

Enveloped viruses understood via multiscale simulation: computer-aided vaccine design

(2008) Z. Shreif et al.  

Quantitative analysis of virus-like particle size and distribution by field-flow fractionation

(2007) Yap P. Chuan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Escherichia coli-based cell-free synthesis of virus-like particles

(2007) Bradley C. Bundy et al.   BIOTECHNOLOGY AND BIOENGINEERING