Article
Virology
Hao Zheng, Yong Pan, Xiong Wang, Weibin Tian, Lunguang Yao, Jingchen Sun
Summary: By screening for suitable promoters, utilizing the envelope display effect of INVASIN and VSVG proteins, and constructing a recombinant baculovirus vector, the study was able to improve the efficiency and effectiveness of the baculovirus display system, providing a foundation for further development.
Article
Immunology
Vaibhvi Vaibhvi, Sven Kuenzel, Thomas Roeder
Summary: The immune organs of the fruit fly, Drosophila, namely the fat body and hemocytes, show distinct responses to systemic infection. The fat body exhibits improved peptide synthesis and export, while hemocytes display enhanced phagocytic signatures.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Sandra R. Abbo, Wilson Nguyen, Marleen H. C. Abma-Henkens, Denise van de Kamer, Niek H. A. Savelkoul, Corinne Geertsema, Thuy T. T. Le, Bing Tang, Kexin Yan, Troy Dumenil, Monique M. van Oers, Andreas Suhrbier, Gorben P. Pijlman
Summary: Mayaro virus is associated with acute rheumatic disease and has the potential to emerge as a tropical public health threat. Researchers developed a virus-like particle vaccine against Mayaro virus, which induced neutralizing antibodies and protected mice against infection and disease.
JOURNAL OF VIROLOGY
(2023)
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shudi Zhao, Guanping Chen, Xiangshuo Kong, Nan Chen, Xiaofeng Wu
Summary: Antiviral immunity involves RNA interference (RNAi) pathway, and viruses can evade this defense by encoding viral suppressors of RNAi (VSRs). We found that p35 of BmNPV disrupts siRNA function and prevents their loading into Ago2, enhancing viral replication.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
A. Dziedziech, U. Theopold
Summary: This study provides evidence for the ancient origin of pyroptosis in Drosophila melanogaster, showing that the inflammatory based programmed cell death mechanism fits the features of pyroptosis and relies on ancient apoptotic machinery.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Virology
Joe McKellar, Antoine Rebendenne, Melanie Wencker, Olivier Moncorge, Caroline Goujon
Summary: Host cells have developed a multi-modular system to detect and combat influenza viruses, including interferon response and intrinsic immunity. These mechanisms activate a wide array of antiviral effectors that inhibit virus replication at various stages, providing important insights for the development of new influenza treatments.
Article
Immunology
Awadalkareem Adam, Huanle Luo, Samantha R. Osman, Binbin Wang, Christopher M. Roundy, Albert J. Auguste, Kenneth S. Plante, Bi-Hung Peng, Saravanan Thangamani, Elena I. Frolova, Ilya Frolov, Scott C. Weaver, Tian Wang
Summary: The study demonstrates that the EILV/CHIKV vaccine candidate is safe, cost-effective to produce and a potent inducer of both innate and adaptive immunity in mice, showing good effects on CHIKV-specific antibodies and memory B cells, as well as CD8(+) T cell responses.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Immunology
Qiaonan Hong, Jian Liu, Yuquan Wei, Xiawei Wei
Summary: Vaccination is an effective strategy to control epidemics, and the baculovirus expression vector system (BEVS) is a promising technology for vaccine production due to its safety and rapid production. This review provides an overview of the development history of BEVS, the procedures for preparing recombinant protein vaccines using the BEVS platform, and the features and limitations of this platform. The progress of BEVS platform-related research, particularly in the field of vaccine, is highlighted, along with a future prospect for BEVS in vaccine manufacturing.
Review
Pharmacology & Pharmacy
Takahiro Kusakabe
Summary: The outbreak of SARS-2-CoV infection has become a global pandemic with significant fatalities. The risk of pandemics is increasing due to environmental changes and the globalization of human exchange and logistics. However, our preparedness for emerging infectious diseases caused by unknown viruses is insufficient, making it crucial to address viral infections immediately.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Virology
Wenhui Xue, Tingting Li, Sibo Zhang, Yingbin Wang, Minqing Hong, Lingyan Cui, Hong Wang, Yuyun Zhang, Tingting Chen, Rui Zhu, Zhenqin Chen, Lizhi Zhou, Rongwei Zhang, Tong Cheng, Qingbing Zheng, Jun Zhang, Ying Gu, Ningshao Xia, Shaowei Li
Summary: In this study, a new immunogen for vaccine design was created by displaying VZV-gE on the baculovirus surface. The engineered baculovirus demonstrated correct localization and display of gE. The resulting vaccine showed excellent antigenicity against VZV and induced stronger immune responses in mice, making it a promising candidate for HZ vaccine development.
Article
Chemistry, Multidisciplinary
Ryotaro Oyama, Harumichi Ishigame, Hiroki Tanaka, Naho Tateshita, Moeko Itazawa, Ryosuke Imai, Naomasa Nishiumi, Jun-ichi Kishikawa, Takayuki Kato, Jessica Anindita, Yoshifumi Nishikawa, Masatoshi Maeki, Manabu Tokeshi, Kota Tange, Yuta Nakai, Yu Sakurai, Takaharu Okada, Hidetaka Akita
Summary: RNA vaccines based on lipid nanoparticles with enhanced capability for inducing cellular immunity have shown promising results in both tumor models and infection models. In this study, an ionizable lipid with a vitamin E scaffold was used to develop RNA vaccines that successfully induced antigen-specific CD8(+) T cell responses and conferred protection against lethal infection. Additionally, conventional dendritic cells were found to be essential for the induction of CD8(+) T cell responses.
Article
Biochemistry & Molecular Biology
Xianglei Yan, Sebastian Ols, Rodrigo Arcoverde Cerveira, Klara Lenart, Fredrika Hellgren, Kewei Ye, Alberto Cagigi, Marcus Buggert, Falk Nimmerjahn, Jesper Falkesgaard Hojen, Daniel Parera, Ulrich Pessara, Stephan Fischer, Karin Lore
Summary: Targeting CD40 with agonistic antibodies can stimulate immune responses and be used as vaccine adjuvants or for cancer immunotherapy. A specific agonistic anti-human CD40 monoclonal IgG1 antibody (MAB273) lacking Fc gamma-receptor binding was introduced. MAB273 rapidly bound to B cells and dendritic cells, resulting in activation in vitro and in vivo. It enhanced antigen-specific T cell responses and could be a promising immunostimulatory adjuvant for therapeutic and prophylactic vaccination strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Microbiology
Jiao Hu, Qi Zhang, Peipei Peng, Rumeng Li, Jun Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Shunlin Hu, Xiaowen Liu, Mei Mei, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: This study generated a H7N9 virus-like particle (VLP) vaccine and evaluated its efficacy in chickens and mice. The H7N9 VLP induced robust antibody immune responses and provided complete clinical protection against H7N9 virus challenge in both animal models. Additionally, the vaccine significantly reduced virus shedding and alleviated pulmonary lesions. Moreover, the H7N9 VLP also induced high T cell immunity and decreased the expression of inflammatory cytokines in mouse lungs. These findings highlight the potential of VLP-based vaccines as an alternative to traditional egg-based vaccines for controlling H7N9 influenza virus in both humans and poultry.
VETERINARY MICROBIOLOGY
(2022)
