An overview of spirooxindole as a promising scaffold for novel drug discovery

Natural heat shock protein 90 inhibitors in cancer and inflammation

(2020) Thadeu E.M.M. Costa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies

(2020) Sarwat Chowdhury et al.   MOLECULES

Convenient synthesis of spirooxindoles using SnO2 nanoparticles as effective reusable catalyst at room temperature and study of their in vitro antimicrobial activity

(2019) Leila Moradi et al.   Journal of the Iranian Chemical Society

A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

(2019) Joana D. Amaral et al.   Frontiers in Chemistry

The Still Underestimated Problem of Fungal Diseases Worldwide

(2019) Fausto Almeida et al.   Frontiers in Microbiology

Bifunctional opioid receptor ligands as novel analgesics

(2019) Christopher W. Cunningham et al.   NEUROPHARMACOLOGY

Structural Simplification of Natural Products

(2019) Shengzheng Wang et al.   CHEMICAL REVIEWS

New SIRT2 inhibitors: Histidine-based bleomycin spin-off

(2019) Taha F.S. Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction

(2019) Assem Barakat et al.   BIOORGANIC CHEMISTRY

Combined Scaffold Evaluation and Systems‐level Transcriptome‐Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes

(2019) Kevin Rodriguez et al.   ChemMedChem

Recent Progress on Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers

(2019) Ting Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

(2019) Susan Wyllie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Catalysis of Ag(I) and Organo-N -heterocyclic Carbenes: One-Pot Synthesis of New Anticancer Spirooxindole-1,4-dihydropyridines

(2019) Ramesh Balaboina et al.   ChemistrySelect

Design, synthesis and biological evaluation of novel antitumor spirodihydrothiopyran-oxindole derivatives

(2019) Wei Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of a spiroindolone pyrothiazole analog via X-ray, biological, and computational studies

(2019) Mezna Saleh Altowyan et al.   JOURNAL OF MOLECULAR STRUCTURE

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

(2019) Khurshed Bozorov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PLK4: a promising target for cancer therapy

(2019) Yi Zhao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Asymmetric Total Syntheses of Rhynchophylline and Isorhynchophylline

(2019) Zhihong Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

The role of polo‐like kinase 3 in the response of BRAF‐mutant cells to targeted anticancer therapies

(2019) Mahamat Babagana et al.   MOLECULAR CARCINOGENESIS

Synthesis of Oxindole Analogues, Biological Activity, and In Silico Studies

(2019) Gehad Lotfy et al.   ChemistrySelect

Combination Therapy Strategies for the Treatment of Malaria

(2019) Sibusiso Alven et al.   MOLECULES

A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas

(2019) Susanne A. Gatz et al.   Frontiers in Oncology

A review of the traditional use of southern African medicinal plants for the treatment of malaria

(2019) I.E. Cock et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthesis of spirooxindolocarbamates based on Betti reaction: antibacterial, antifungal and antioxidant activities

(2019) Venkata Bharat Nishtala et al.   MOLECULAR DIVERSITY

Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors

(2019) Wen Ren et al.   MOLECULAR DIVERSITY

Unexpected regio- and stereoselective [4 + 3] cycloaddition reaction of azomethine ylides with benzylidene thiazolidinediones: synthesis of pharmacologically active spiroindoline oxazepine derivatives and theoretical study

(2019) Mahboobeh Zahedifar et al.   MOLECULAR DIVERSITY

Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

(2019) Biao Wang et al.   Acta Pharmaceutica Sinica B

DARK Classics in Chemical Neuroscience: Morphine

(2018) Andrea L. Devereaux et al.   ACS Chemical Neuroscience

Catalytic asymmetric synthesis of spirooxindoles: recent developments

(2018) Guang-Jian Mei et al.   CHEMICAL COMMUNICATIONS

One-pot four-component domino strategy for the synthesis of novel spirooxindole–pyrrolidine/pyrrolizidine-linked 1,2,3-triazole conjugates via stereo- and regioselective [3+2] cycloaddition reactions: In vitro antibacterial and antifungal studies

(2018) Randa Sakly et al.   COMPTES RENDUS CHIMIE

Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-α and nitrite inhibition

(2018) Raju Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

(2018) Margherita Ortalli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma

(2018) Renata Nishida Goto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cinchona Alkaloid Thiourea Catalyzed Asymmetric Synthesis and Anticancer Activity Evaluation of Tetrahydro-β-spirooxindoles

(2018) Weihui Zhong et al.   HETEROCYCLES

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

(2018) Chun Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Task-specific Ionic Liquid Mediated Eco-compatible Approach for the Synthesis of Spirooxindole Derivatives and Their DNA Cleavage Activity

(2018) Anshu Dandia et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

New spiro-oxindole constructed with pyrrolidine/thioxothiazolidin-4-one derivatives: Regioselective synthesis, X-ray crystal structures, Hirshfeld surface analysis, DFT, docking and antimicrobial studies

(2018) Assem Barakat et al.   JOURNAL OF MOLECULAR STRUCTURE

Cyclopiamines C and D: Epoxide Spiroindolinone Alkaloids from Penicillium sp. CML 3020

(2018) Sara Kildgaard et al.   JOURNAL OF NATURAL PRODUCTS

Regio- and stereoselective synthesis of new spirooxindoles via 1,3-dipolar cycloaddition reaction: Anticancer and molecular docking studies

(2018) Gehad Lotfy et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael–aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity

(2018) Shengzheng Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dynamic activation and regulation of the mitogen-activated protein kinase p38

(2018) Ganesan Senthil Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regio- and diastereoselective synthesis of anticancer spirooxindoles derived from tryptophan and histidine via three-component 1,3-dipolar cycloadditions in an ionic liquid

(2018) Natarajan Arumugam et al.   TETRAHEDRON

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

(2018) Assem Barakat et al.   RSC Advances

Diastereoselective synthesis of dispirooxindoles via [3+2] cycloaddition of azomethine ylides to 3-phenacylideneoxindoles and evaluation of their cytotoxicity

(2018) Ying Huang et al.   RSC Advances

Novel 1,4-dihydropyridine induces apoptosis in human cancer cells through overexpression of Sirtuin1

(2018) Debashri Manna et al.   APOPTOSIS

An eco-friendly catalytic system for multicomponent, one-pot synthesis of novel spiro-chromeno indoline-triones and their anti-prostate cancer potentials evaluated via alkaline phosphatase inhibition mechanism

(2018) M. Rajesh Kumar et al.   BIOORGANIC CHEMISTRY

Recent Development of Visceral Leishmaniasis Treatments: Successes, Pitfalls, and Perspectives

(2018) Fabiana Alves et al.   CLINICAL MICROBIOLOGY REVIEWS

Tumor necrosis factor-α and C-C motif chemokine ligand 18 associate with atherosclerotic lipid accumulation in situ and in vitro

(2018) Alexander N. Orekhov et al.   CURRENT PHARMACEUTICAL DESIGN

Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

(2018) Yong-Liang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of p53-Murine double minute 2 (MDM2) Interactions with 3,3’-Spirocyclopentene Oxindole Derivatives.

(2018) Maxime Gicquel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of Ionic Liquid-Based Ultrasonic-Assisted Extraction of Flavonoids from Bamboo Leaves

(2018) Liling Wang et al.   MOLECULES

Newer pharmacological approaches for antioxidant neuroprotection in traumatic brain injury

(2018) Edward D. Hall et al.   NEUROPHARMACOLOGY

Pain Management and Opioid Regulation: Continuing Public Health Challenges

(2018) Richard J. Bonnie et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Fe3 O4 nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitors

(2018) Srinubabu Maddela et al.   ARCHIV DER PHARMAZIE

Design and synthesis of simplified speciophylline analogues and β-carbolines as active molecules against Plasmodium falciparum

(2018) David Pierrot et al.   DRUG DEVELOPMENT RESEARCH

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis of novel spirooxindole-pyrrolidines and evaluation of their cytotoxic activity

(2018) Roman Sergeevich Tumskiy et al.   Pharmacological Reports

Natural products as a perspective for cancer pain management: a systematic review

(2018) Daniele Nascimento Gouveia et al.   PHYTOMEDICINE

Synthesis of new thiazolo-pyrrolidine–(spirooxindole) tethered to 3-acylindole as anticancer agents

(2018) Mohammad Shahidul Islam et al.   BIOORGANIC CHEMISTRY

A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours

(2017) Maja de Jonge et al.   EUROPEAN JOURNAL OF CANCER

Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties

(2017) Carlos J.A. Ribeiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy

(2017) Saeed Emami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,4-Substituted Triazoles as Nonsteroidal Anti-Androgens for Prostate Cancer Treatment

(2017) Claudia Ferroni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Functionalized 3-Spiro[cyclopropa[a]pyrrolizine]- and 3-Spiro[3-azabicyclo[3.1.0]hexane]oxindoles from Cyclopropenes and Azomethine Ylides via [3 + 2]-Cycloaddition

(2017) Alexander S. Filatov et al.   JOURNAL OF ORGANIC CHEMISTRY

Strategies to diversify natural products for drug discovery

(2017) Gang Li et al.   MEDICINAL RESEARCH REVIEWS

Spirooxindoles as Potential Pharmacophores

(2017) Siva S. Panda et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Facial Regioselective Synthesis of Novel Bioactive Spiropyrrolidine/Pyrrolizine-Oxindole Derivatives via a Three Components Reaction as Potential Antimicrobial Agents

(2017) Huwaida Hassaneen et al.   MOLECULES

Na V 1.7 as a pain target – From gene to pharmacology

(2017) Irina Vetter et al.   PHARMACOLOGY & THERAPEUTICS

Docking and QSAR studies of 1,4-Dihydropyridine derivatives as anticancer agent

(2017) Shirin Mollazadeh et al.   Recent Patents on Anti-Cancer Drug Discovery

p53 and MDM2: their Yin-Yang intimacy

(2017) Hua Lu   Journal of Molecular Cell Biology

1,3-Dipolar Cycloaddition Reactions for the Synthesis of Novel Oxindole Derivatives and Their Cytotoxic Properties

(2017) Prakash R. Mali et al.   ACS Combinatorial Science

Highly Efficient Synthesis of Spirooxindole, Spiroacenaphthylene and Bisbenzo[b]pyran Derivatives and Evaluation of Their Inhibitory Activity against Sirtuin 2

(2017) Alireza Hasaninejad et al.   ChemistrySelect

Highly Diastereoselective Syntheses of Spiro-Oxindole Dihydrofuran Derivatives in Aqueous Media and Their Antibacterial Activity

(2017) Naveen Gupta et al.   ChemistrySelect

p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents

(2017) Surendra Kumar Nayak et al.   CURRENT CANCER DRUG TARGETS

A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites bothIn VitroandIn Vivoby Targeting Type IB Topoisomerase

(2016) Sourav Saha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Application of PEG-400 as a green biodegradable polymeric medium for the catalyst-free synthesis of spiro-dihydropyridines and their use as acetyl and butyrylcholinesterase inhibitors

(2016) Ammar Maryamabadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

(2016) Stephen D. Lotesta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of SOAT2 inhibitors from synthetic small molecules

(2016) Keisuke Kobayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Gold catalyzed double condensation reaction: Synthesis, antimicrobial and cytotoxicity of spirooxindole derivatives

(2016) K. Parthasarathy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis

(2016) Holly J. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ultrasound Promoted Synthesis of Novel Substituted Spirooxindole Compounds Containing Thiochroman Moiety with Antifungal Activity

(2016) Guan Zhou et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach

(2016) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxindole: A chemical prism carrying plethora of therapeutic benefits

(2016) Maninder Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antimicrobial Evaluations of Novel Spiro Cyclic 2-Oxindole Derivatives of N-(1H-Pyrazol-5-Yl)-Hexahydroquinoline Derivatives

(2016) Amr Mohamed Abdelmoniem et al.   HETEROCYCLES

Design, Synthesis, and Biological Activities of Spirooxindoles Containing Acylhydrazone Fragment Derivatives Based on the Biosynthesis of Alkaloids Derived from Tryptophan

(2016) Linwei Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209

(2016) Aika Suzuki et al.   JOURNAL OF ANTIBIOTICS

Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid

(2016) Danilo Del Prete et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor

(2016) E. R. de Kloet et al.   JOURNAL OF NEUROENDOCRINOLOGY

Synthesis, biological evaluation and molecular docking studies of some novel indenospiro derivatives as anticancer agents

(2016) Ajinkya A. Patravale et al.   Journal of the Taiwan Institute of Chemical Engineers

Synthesis, antimicrobial and cytotoxic evaluation of spirooxindole[pyrano-bis-2H-l-benzopyrans]

(2016) K. Parthasarathy et al.   MEDICINAL CHEMISTRY RESEARCH

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction

(2016) Agostinho Lemos et al.   MEDICINAL RESEARCH REVIEWS

Synthesis of first ever 4-quinolone-3-carboxylic acid-appended spirooxindole-pyrrolidine derivatives and their biological applications

(2016) Thangaraj Arasakumar et al.   MOLECULAR DIVERSITY

Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

(2016) Sadasivam Mathusalini et al.   NEW JOURNAL OF CHEMISTRY

A convenient and rapid microwave-assisted synthesis of spirooxindoles in aqueous medium and their antimicrobial activities

(2016) Prakash R. Mali et al.   NEW JOURNAL OF CHEMISTRY

Catalytic asymmetric hetero-Diels–Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives

(2016) Hai-Lei Cui et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

(2016) Shengzheng Wang et al.   ORGANIC LETTERS

One-Pot Synthesis of Spiro[chromeno[2,3-c]pyrazole-4,3′-indoline]-diones Using Sulfonic Acid Functionalized Nanoporous Silica SBA-Pr-SO3H and Study of Their Antimicrobial Properties

(2016) Ghodsi Mohammadi Ziarani et al.   POLYCYCLIC AROMATIC COMPOUNDS

Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities

(2016) Jun Yang et al.   TETRAHEDRON

1,3-Dipolar cycloaddition enabled isoxazole-fused spiropyrrolidine oxindoles syntheses from 3-methyl-4-nitro-5-alkenyl-isoxazoles and azomethine ylides

(2016) Xiong-Wei Liu et al.   TETRAHEDRON

Construction of turmerone motif-fused spiropyrrolidine oxindoles and their biological evaluation for anticancer activities

(2016) Xiong-Li Liu et al.   TETRAHEDRON LETTERS

Synthesis of new spirooxindole derivatives through 1,3-dipolar cycloaddition of azomethine ylides and their antitubercular activity

(2016) Fadwa Rouatbi et al.   TETRAHEDRON LETTERS

The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling

(2016) Rein M. G. J. Houben et al.   PLOS MEDICINE

Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions

(2016) Li Tian et al.   Asian Journal of Organic Chemistry

Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

(2016) Bo Cao et al.   eLife

Therapeutic Potential of Spirooxindoles as Antiviral Agents

(2016) Na Ye et al.   ACS Infectious Diseases

Spiro-oxindoles as a Promising Class of Small Molecule Inhibitors of p53–MDM2 Interaction Useful in Targeted Cancer Therapy

(2016) Alpana K. Gupta et al.   Topics in Current Chemistry

Recent Advances in Green Synthesis of 3,3′-Spirooxindoles via Isatin-based One-pot Multicomponent Cascade Reactions in Aqueous Medium

(2016) Li-Jun Yan et al.   ChemistrySelect

Clinical Overview of MDM2/X-Targeted Therapies

(2016) Andrew Burgess et al.   Frontiers in Oncology

Structurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanisms

(2016) Xiao-Jing Shi et al.   Scientific Reports

Sulfamic acid promoted one-pot three-component synthesis and cytotoxic evaluation of spirooxindoles

(2015) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of oxazolones-grafted spirooxindoles via three-component diversity oriented synthesis and their preliminary biological evaluation

(2015) Hui Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities

(2015) D. Kathirvelan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures

(2015) Natalia Estrada-Ortiz et al.   ChemMedChem

Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies

(2015) Yonglong Xiao et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies

(2015) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule MDM2-p53 inhibitors: recent advances

(2015) Bian Zhang et al.   Future Medicinal Chemistry

Molecular diversity of spirooxindoles. Synthesis and biological activity

(2015) Tetyana L. Pavlovska et al.   MOLECULAR DIVERSITY

A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies

(2015) Saoussen Haddad et al.   NEW JOURNAL OF CHEMISTRY

Facile synthesis of spirooxindole-pyrazolines and spirobenzofuranone-pyrazolines and their fungicidal activity

(2015) Changjiang Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and antifungal activities of novel polyheterocyclic spirooxindole derivatives

(2015) Jia-Shou Wu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cu(OTf)2 catalyzed three component strategy for the synthesis of thienopyridine containing spirooxindoles and their cytotoxic evaluation

(2015) K. Parthasarathy et al.   RSC Advances

Ionic liquid mediated synthesis of mono- and bis-spirooxindole-hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies

(2014) Yalda kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9

(2014) Kai Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-hyperlipidemic and Anti-oxidative Effects of Gelsemine in High-Fat-Diet-Fed Rabbits

(2014) Tao Wu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Nephroprotective Effect of Gelsemine Against Cisplatin-Induced Toxicity is Mediated Via Attenuation of Oxidative Stress

(2014) Lin Lin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cholesterol Esters (CE) Derived From Hepatic Sterol O-Acyltransferase 2 (SOAT2) Are Associated With More Atherosclerosis Than CE From Intestinal SOAT2

(2014) Jun Zhang et al.   CIRCULATION RESEARCH

Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines

(2014) Ângelo Monteiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Recent advances in the synthesis of biologically active spirooxindoles

(2014) Maria M.M. Santos   TETRAHEDRON

An Asymmetric Diels-Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles

(2013) Guilong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors

(2013) Yalda Kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole–pyrrolizine–piperidine hybrids

(2013) Yalda Kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3′-indoline]-2′,4,9-triones

(2013) E. Rajanarendar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Skeletal Rearrangement, and Biological Activities of Spirooxindoles: Exploration of a StepwiseC-Piancatelli Rearrangement

(2013) Li Huang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recent Progress on Routes to Spirooxindole Systems Derived from Isatin

(2013) Min Xia et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

(2013) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity

(2012) Gangaru Bhaskar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function

(2012) Ting Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark

(2012) R. Rojas-Duran et al.   JOURNAL OF ETHNOPHARMACOLOGY

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

(2012) Petr Vachal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-catalysed approach to spirocyclic oxindoles via a direct C–H, Ar-H functionalisation

(2012) Catherine L. Moody et al.   TETRAHEDRON LETTERS

Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode

(2011) Paul Eastwood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

(2011) Sultan Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Antioxidant Activity of New Coumarin Derivatives

(2011) Abdul Amir H. Kadhum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biosynthetic Studies of the Notoamides: Isotopic Synthesis of Stephacidin A and Incorporation into Notoamide B and Sclerotiamide

(2011) Jennifer M. Finefield et al.   ORGANIC LETTERS

Total synthesis of (±)-coerulescine and (±)-horsfiline

(2010) Mukund G Kulkarni et al.   Beilstein Journal of Organic Chemistry

Synthesis and antioxidant activity of quinolinobenzothiazinones

(2010) M. Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

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