Recent Progress on Routes to Spirooxindole Systems Derived from Isatin

Synthesis of Spiro Heterocyclic Compounds

(2012) Mohamed N. Ibrahim et al.   E-Journal of Chemistry

A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation

(2010) Shanmugavel Uma Maheswari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction

(2010) Kodirajan Selvakumar et al.   CHEMICAL COMMUNICATIONS

4-hydroxy-2-quinolones 172*. Synthesis and structure of 4,3'-spiro[(6-allyl-2-amino- 5-oxo-5,6-dihydro-4h-pyrano- [3,2-c]quinoline-3-carbo- nitrile)-2'-oxindole]

(2010) I. V. Ukrainets et al.   Chemistry of Heterocyclic Compounds

Synthesis of Novel Spiro Pyrrolidine and Pyrrolizine Derivatives by 1,3-Dipolar Cycloaddition

(2010) Xiaofang Li et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis of Novel Trispiroheterocycles through 1,3-Dipolar Cycloaddition of Azomethine Ylides and Nitrile Oxide

(2010) Xiaofang Li et al.   CHINESE JOURNAL OF CHEMISTRY

A simple and catalyst-free three-component method for the synthesis of spiro[indenopyrazolopyridine indoline]diones and spiro[indenopyridopyrimidine indoline]triones

(2010) Ghazaleh Imani Shakibaei et al.   COMPTES RENDUS CHIMIE

Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines

(2010) K. Karthikeyan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide

(2010) Arumugam Thangamani   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficient One-Pot Synthesis of Novel Spirooxindole Derivatives via Three-Component Reaction in Aqueous Medium

(2010) Hui Chen et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Regioselective Synthesis of Novel Spiropyrrolidines and Spirothiapyrrolizidines Through Multicomponent 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylides

(2010) Hai Liu et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

One-pot synthesis of spiro[diindeno[1,2-b:2′,1′-e]pyridine-11,3′-indoline]-triones

(2010) Ramin Ghahremanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of trispiro[oxindole-pyrrolidine]-cyclopentanone-isoxazolines by 1,3-dipolar cycloaddition

(2010) Xiaofang Li et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

One-pot synthesis of new spiro[cyclopropane-1,3′-[3H]indol]-2′(1′H)-ones from 3-phenacylideneoxindoles

(2010) Masoud Shaabanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

One-pot and three-component synthesis of spiro[chromeno[2,3-d] pyrimidine-5,3′-indoline]-diones and spiro[chromeno[2,3-c] pyrazole-4,3′-indoline]-diones

(2010) Ramin Ghahremanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A clean and one-pot synthesis of spiroindoline-pyranopyrazoles

(2010) Somayeh Ahadi et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A Novel Biginelli-Like Reaction: An Efficient One-pot Synthesis of Spiro[oxindole-quinazoline/pyrimidine]ones

(2010) Hassan Kefayati et al.   LETTERS IN ORGANIC CHEMISTRY

Pyridine Core Activationvia1,5-Electrocyclization of Vinyl Pyridinium Ylides Generated from Bromo Isomerized Morita−Baylis−Hillman Adduct of Isatin and Pyridine: Synthesis of 3-Spirodihydroindolizine Oxindoles

(2010) Baby Viswambharan et al.   ORGANIC LETTERS

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles

(2010) Bo Liang et al.   ORGANIC LETTERS

New method of synthesis of β,β′-spiropyrrolidinooxindoles

(2010) A. A. Shvets et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Novel Spiro[dihydropyridine-oxindole] Compounds in Water

(2010) Kurosh Rad-Moghadam et al.   SYNLETT

Efficient One-Pot Synthesis of Spirooxindole Derivatives Containing 1,4-Dihydropyridine-Fused-1,3-Diazaheterocycle Fragments via Four-Component Reaction

(2010) Abdolali Alizadeh et al.   SYNTHESIS-STUTTGART

Novel Mono- and Bis(spiro-2-amino-4H-pyrans): Alum-Catalyzed Reaction of 4-Hydroxycoumarin and Malononitrile with Isatins, Quinones, or Ninhydrin

(2010) Ali Karimi et al.   SYNTHESIS-STUTTGART

Synthesis of Novel Spiroheterocycles Through 1,3-Dipolar Cycloaddition of Azomethine Ylides with Triarylideneacetylacetone Through Decarboxylation

(2010) Ramalingam Murugan et al.   SYNTHETIC COMMUNICATIONS

A facile synthesis of chromeno[3,4-c]spiropyrrolidine-oxindoles via 1,3-dipolar cycloadditions

(2010) Mehdi Ghandi et al.   TETRAHEDRON

One-pot approach for the stereoselective synthesis of spirocyclopropyl oxindoles from isatins and arsonium salts

(2010) Haigang Yu et al.   TETRAHEDRON

Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition

(2010) Abhijit Hazra et al.   TETRAHEDRON LETTERS

Sonochemical multi-component synthesis of spirooxindoles

(2010) Minoo Dabiri et al.   ULTRASONICS SONOCHEMISTRY

Ultrasound-promoted synthesis of novel spirooxindolo/spiroacenaphthen dicyano pyrrolidines and pyrrolizidines through regioselective azomethine ylide cycloaddition reaction

(2010) Seyed Jamal Tabatabaei Rezaei et al.   ULTRASONICS SONOCHEMISTRY

Multi-component supramolecular synthesis of spirooxindoles catalyzed by β-cyclodextrin in water

(2009) Regati Sridhar et al.   CANADIAN JOURNAL OF CHEMISTRY

A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines

(2009) Raju Ranjith Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An efficient, three-component synthesis of spiro[benzo[g]chromene-4,3′-indoline]-3-carbonitrile and spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine]-6′-carbonitrile derivatives

(2009) Ramin Ghahremanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Electrochemically induced multicomponent assembling of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile: a convenient and efficient way to functionalized spirocyclic [indole-3,4′-pyrano[3,2-c]quinoline] scaffold

(2009) Michail N. Elinson et al.   MOLECULAR DIVERSITY

Stereoselective Synthesis of Spirooxindoles by Palladium-Catalyzed Decarboxylative Cyclization of γ-Methylidene-δ-valerolactones with Isatins

(2009) Ryo Shintani et al.   ORGANIC LETTERS

Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations

(2009) M. Paola Castaldi et al.   ORGANIC LETTERS

Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5 + 2]-Annulation of Chiral Silyl Alcohols

(2009) Yun Zhang et al.   ORGANIC LETTERS

Versatile three-component synthesis of 2′-amino-1,2-dihydrospiro[(3H)-indole-3,4′-(4′H)-pyran]-2-ones

(2009) V. Yu. Mortikov et al.   RUSSIAN CHEMICAL BULLETIN

An expedient synthesis of ferrocene grafted spirooxindolopyrrolizidines via [3+2]-cycloaddition of azomethine ylides

(2009) A.R. Suresh Babu et al.   TETRAHEDRON

A regioselective three-component reaction for synthesis of novel 1′H-spiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione derivatives

(2009) Ali A. Mohammadi et al.   TETRAHEDRON

Ammonium salt catalyzed multicomponent transformation: simple route to functionalized spirochromenes and spiroacridines

(2009) Minoo Dabiri et al.   TETRAHEDRON

DBU-Catalyzed, facile and efficient method for synthesis of spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and fused derivatives via [3+3] atom combination

(2009) Ismail A. Abdelhamid et al.   TETRAHEDRON

Sodium stearate-catalyzed multicomponent reactions for efficient synthesis of spirooxindoles in aqueous micellar media

(2009) Li-Min Wang et al.   TETRAHEDRON

A facile one-pot three-component synthesis of ferrocene-grafted dispiro pyrrolidine/pyrrolizidine scaffolds through intermolecular [3+2] cycloaddition reaction of ferrocenyl Baylis–Hillman adduct

(2009) Subban Kathiravan et al.   TETRAHEDRON LETTERS

Synthesis of novel spiropyrrolidine/pyrrolizine-oxindole scaffolds through 1,3-dipolar cycloadditions

(2009) Mehdi Ghandi et al.   TETRAHEDRON LETTERS

Grindstone chemistry: one-pot synthesis of spiro[diindenopyridine-indoline]triones and spiro[acenaphthylene-diindenopyridine]triones

(2009) Ramin Ghahremanzadeh et al.   TETRAHEDRON LETTERS

An expedient approach for the synthesis of dispiropyrrolidine bisoxindoles, spiropyrrolidine oxindoles and spiroindane-1,3-diones through 1,3-dipolar cycloaddition reactions

(2009) Neelakandan Vidhya Lakshmi et al.   TETRAHEDRON LETTERS

Ultrasound-assisted one-pot, three-component synthesis of spiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-2,6′(1′H)-diones in water

(2009) Ayoob Bazgir et al.   ULTRASONICS SONOCHEMISTRY

A Clean Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives

(2008) Somayeh Ahadi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Regioselective synthesis and stereochemical structure of anti-tumor active dispiro[3H-indole-3,2′-pyrrolidine-3′,3″-piperidine]-2(1H),4″-diones

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3,3-diaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones

(2008) Girija S. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A First Resource-Efficient and Highly Flexible Procedure for a Four-Component Synthesis of Dispiropyrrolidines

(2008) Ming Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Versatile Three-Component Procedure for Combinatorial Synthesis of 2-Aminospiro[(3′H)-indol-3′,4-(4H)-pyrans]

(2008) Yuri M. Litvinov et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention

(2008) Raju Ranjith Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Indium Trichloride Catalysed Imino Diels-Alder Reaction of Imesatins: A Facile Synthesis of Novel Spirooxindole 1H – pyrano[2,3-c ]quinolines

(2008) R. Raghunathan et al.   LETTERS IN ORGANIC CHEMISTRY

Electrocatalytic multicomponent assembling of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile: facile and convenient way to functionalized spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazole] system

(2008) Michail N. Elinson et al.   MOLECULAR DIVERSITY

An efficient and convenient protocol for the synthesis of novel 1′H-spiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione derivatives

(2008) M. Dabiri et al.   MONATSHEFTE FUR CHEMIE

Polar [3 + 2] cycloaddition of ketones with electrophilically activated carbonyl ylides. Synthesis of spirocyclic dioxolane indolinones

(2008) Ghenia Bentabed-Ababsa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Short and Efficient Synthesis of 3-Spiro-α-methylene-γ-butyrolactone Oxindolones from Isomerised Bromo Derivatives of Morita-Baylis-Hillman Adducts

(2008) Ponnusamy Shanmugam et al.   SYNLETT

Regioselective Synthesis of Novel Dispiro‐oxindoloindenoquinoxaline Pyrrolidines through 1,3‐Dipolar Cycloaddition Methodology

(2008) A. R. Suresh Babu et al.   SYNTHETIC COMMUNICATIONS

Stereoselective synthesis of 3-spiro-α-methylene-γ-butyrolactone oxindoles from Morita–Baylis–Hillman adducts of isatin

(2008) Ponnusamy Shanmugam et al.   TETRAHEDRON

An efficient synthesis of spiro[dibenzo[b,i]xanthene-13,3′-indoline]-pentaones and 5H-dibenzo[b,i]xanthene-tetraones

(2008) Ayoob Bazgir et al.   TETRAHEDRON LETTERS

A facile and efficient synthesis of highly functionalised 3,3′-dispiropyrrolidine- and 3,3′-dispiropyrrolizidine bisoxindoles via [3+2] cycloaddition

(2008) Ponnusamy Shanmugam et al.   TETRAHEDRON LETTERS

Synthesis of ferrocenyl monospirooxindolopyrrolidines—a facile [3+2]-cycloaddition of azomethine ylides

(2008) A.R. Suresh Babu et al.   TETRAHEDRON LETTERS

A simple entry to novel spiro dihydroquinoline-oxindoles using Povarov reaction between 3-N-aryliminoisatins and isoeugenol

(2008) Vladimir V. Kouznetsov et al.   TETRAHEDRON LETTERS

An easy access to novel steroidal dispiropyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides

(2008) A.R. Suresh Babu et al.   TETRAHEDRON LETTERS

Ultrasound-promoted synthesis of novel dispirocyclic frameworks from aza-Claisen rearrangements of Baylis–Hillman amines

(2008) Shao-Qin Ge et al.   ULTRASONICS SONOCHEMISTRY