Combination Therapy Strategies for the Treatment of Malaria

New hybrid trifluoromethylquinolines as antiplasmodium agents

(2019) Renata M.R.J. da Silva et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, characterization and in vitro analysis of polymer-based conjugates containing dihydrofolate reductase inhibitors

(2019) B.A. Aderibigbe et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation

(2019) Anu Rani et al.   BIOORGANIC CHEMISTRY

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin

(2018) Aysun Çapcı Karagöz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

(2018) Christo de Lange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drugs in Development for Malaria

(2018) Elizabeth A. Ashley et al.   DRUGS

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

(2018) Rita Capela et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Co-nanoencapsulation of antimalarial drugs increases their in vitro efficacy against Plasmodium falciparum and decreases their toxicity to Caenorhabditis elegans

(2018) Kelle Velasques et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enhanced antimalalarial activity of a prolonged release in situ gel of arteether–lumefantrine in a murine model

(2018) Shilpa Dawre et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model

(2018) Oyetunde Oyeyemi et al.   Frontiers in Pharmacology

Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers

(2018) Guowen Yan et al.   Nanomaterials

Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review

(2018) Sarwar Hossen et al.   Journal of Advanced Research

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

(2018) Christo de Lange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies

(2018) Leonardo Bonilla-Ramirez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Substituted aminoquinoline-pyrimidine hybrids: Synthesis, in vitro antimalarial activity evaluation and docking studies

(2018) Shiv S. Maurya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polymeric Nanocarriers for the Delivery of Antimalarials

(2018) Zandile Mhlwatika et al.   MOLECULES

Design, synthesis and evaluation of 4-aminoquinoline-purine hybrids as potential antiplasmodial agents

(2017) P. Linga Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N -Piperonyl substitution on aminoquinoline-pyrimidine hybrids: Effect on the antiplasmodial potency

(2017) Rohit Kholiya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antimalarial activity, heme binding and docking studies of N -substituted 4-aminoquinoline-pyrimidine molecular hybrids

(2017) Shiv Shyam Maurya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Polymeric nanoparticles: A study on the preparation variables and characterization methods

(2017) Carina I.C. Crucho et al.   Materials Science & Engineering C-Materials for Biological Applications

Quinoline-Based Hybrid Compounds with Antimalarial Activity

(2017) Xhamla Nqoro et al.   MOLECULES

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Ferroquine, the next generation antimalarial drug, has antitumor activity

(2017) Artem Kondratskyi et al.   Scientific Reports

New pentasubstituted pyrrole hybrid atorvastatin–quinoline derivatives with antiplasmodial activity

(2016) Rita C.C. Carvalho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS

(2016) Supriya Sahu et al.   EXPERIMENTAL PARASITOLOGY

Dual release kinetics of antimalarials from soy protein isolate-carbopol-polyacrylamide based hydrogels

(2016) Blessing Atim Aderibigbe et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Preparation, characterization and in vitro release kinetics of polyaspartamide-based conjugates containing antimalarial and anticancer agents for combination therapy

(2016) B.A. Aderibigbe et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Drug-conjugated PLA–PEG–PLA copolymers: a novel approach for controlled delivery of hydrophilic drugs by micelle formation

(2016) H. Danafar et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives

(2016) Hans Raj Bhat et al.   Arabian Journal of Chemistry

Light-Responsive Polymer Micro- and Nano-Capsules

(2016) Valentina Marturano et al.   Polymers

Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki

(2016) Geoff Dow   Therapeutics and Clinical Risk Management

Antimalarial drug resistance in Africa: key lessons for the future

(2015) Shannon Takala-Harrison et al.   Annals of the New York Academy of Sciences

Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria

(2015) Vinoth Rajendran et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anti- Plasmodium falciparum activity of quinoline–sulfonamide hybrids

(2015) Luiz C.S. Pinheiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro evaluation of novel 8-aminoquinoline–pyrazolopyrimidine hybrids as potent antimalarial agents

(2015) Murugan Kannan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo

(2015) Roberta Reis Soares et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters

(2015) Frans J. Smit et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities

(2015) Rakesh Chopra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline–chalcone and 7-chloroquinoline–ferrocenylchalcone conjugates

(2015) Raghu Raj et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids

(2015) Hardeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin

(2015) Sahil Kumar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoquinoline-1,3,5-triazine derivatives

(2015) Hans Raj Bhat et al.   EXPERIMENTAL PARASITOLOGY

Co-delivery of docetaxel and chloroquine via PEO–PPO–PCL/TPGS micelles for overcoming multidrug resistance

(2015) Chunhuan Shi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy

(2015) Sonja Dragojevic et al.   MOLECULES

Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs

(2014) Julie Movellan et al.   BIOMATERIALS

Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives

(2014) Anna Barteselli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1H-1,2,3-triazole tethered mono- and bis-ferrocenylchalcone-β-lactam conjugates: Synthesis and antimalarial evaluation

(2014) Kewal Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro biological evaluation of aminoacridines and artemisinin–acridine hybrids

(2014) Juan P. Joubert et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Controlled dual release study of curcumin and a 4-aminoquinoline analog from gum acacia containing hydrogels

(2014) Blessing Aderibigbe et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium

(2014) Patricia Urbán et al.   JOURNAL OF CONTROLLED RELEASE

Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates

(2014) Peter Starzengruber et al.   MALARIA JOURNAL

Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates

(2014) Ning Wang et al.   MedChemComm

Bioavailability of phytochemicals and its enhancement by drug delivery systems

(2013) Farrukh Aqil et al.   CANCER LETTERS

Synthesis and biological evaluation of novel ferrocene–naphthoquinones as antiplasmodial agents

(2013) Pedro M. García-Barrantes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Liposome: classification, preparation, and applications

(2013) Abolfazl Akbarzadeh et al.   Nanoscale Research Letters

Synthesis of a new amphiphilic glycodendrimer with antiviral functionality

(2012) Shuqin Han et al.   CARBOHYDRATE POLYMERS

Polymeric Conjugates for Drug Delivery

(2012) Nate Larson et al.   CHEMISTRY OF MATERIALS

Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice

(2012) N.P. Aditya et al.   EXPERIMENTAL PARASITOLOGY

Sustainable malaria control: transdisciplinary approaches for translational applications

(2012) Lyn-Marie Birkholtz et al.   MALARIA JOURNAL

β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study

(2012) Resmi Anand et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

BIOLOGY OF HUMAN MALARIA PLASMODIA INCLUDING PLASMODIUM KNOWLESI

(2012) Spinello Antinori et al.   Mediterranean Journal of Hematology and Infectious Diseases

Layer-by-layer self-assembled shells for drug delivery

(2011) Katsuhiko Ariga et al.   ADVANCED DRUG DELIVERY REVIEWS

Current knowledge and challenges of antimalarial drugs for treatment and prevention in pregnancy

(2010) Esperança Sevene et al.   EXPERT OPINION ON PHARMACOTHERAPY

Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

(2010) Solange Whegang Youdom et al.   MALARIA JOURNAL

Kinetic models of micelles formation

(2009) V. Starov et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Dendrimers: Emerging polymers for drug-delivery systems

(2009) Basavaraj K. Nanjwade et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Micelles and nanoparticles for ultrasonic drug and gene delivery

(2008) Ghaleb A. Husseini et al.   ADVANCED DRUG DELIVERY REVIEWS

Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers

(2008) Tamer Shehata et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structure–activity relationships of 4-N-substituted ferroquine analogues: Time to re-evaluate the mechanism of action of ferroquine

(2008) Christophe Biot et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Investigation of the Redox Behavior of Ferroquine, a New Antimalarial

(2008) Natascha Chavain et al.   MOLECULAR PHARMACEUTICS