Molecular diversity of spirooxindoles. Synthesis and biological activity

Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ

(2015) Xin Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation

(2015) Yogesh P. Bharitkar et al.   MOLECULAR DIVERSITY

Asymmetric synthesis of poly-substituted spirocyclohexane oxindole via a squaramide catalyzed cascade Michael–Michael–aldol sequence

(2015) Qiang-Sheng Sun et al.   Organic Chemistry Frontiers

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

(2014) Tatyana L Pavlovskaya et al.   Beilstein Journal of Organic Chemistry

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly Enantioselective Construction of Spirocyclopentaneoxindoles Containing Four Consecutive Stereocenters through an Organocatalytic Iminium-Enamine Cascade Reaction

(2014) Liang-Zhong Ding et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Diastereoselective Synthesis of Spirocyclopropane Derivatives of Oxindole

(2014) Maksim Ošeka et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Solvent- and transition metal-free synthesis of spiro[cyclopropane-1,3-oxindoles] from cyclic diazoamides

(2014) Sengodagounder Muthusamy et al.   TETRAHEDRON LETTERS

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride (SB-DBU)Cl as a highly efficient, heterogeneous and recyclable silica-supported ionic liquid catalyst for the synthesis of benzo[b]pyran, bis(benzo[b]pyran) and spiro-pyran derivatives

(2013) Alireza Hasaninejad et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

Enantioselective Total Synthesis of (−)-Citrinadin A and Revision of Its Stereochemical Structure

(2013) Zhiguo Bian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Enantioselective Total Synthesis and Stereochemical Revision of (+)-Citrinadin B

(2013) Ke Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation

(2013) Guansheng Wu et al.   MOLECULAR DIVERSITY

Acryl- and methacrylamides. New dipolarophiles in reactions of [2+3]-dipolar cycloaddition to 2-oxindolazomethine ylides

(2013) T. L. Pavlovskaya et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective synthesis of spiro[cyclohexane-1,3′-indolin]-2′-ones containing multiple stereocenters via organocatalytic Michael/aldol cascade reactions

(2013) Arun K. Ghosh et al.   TETRAHEDRON LETTERS

Cover Picture: Champagne and Fireworks:Angewandte ChemieCelebrates Its Birthday (Angew. Chem. Int. Ed. 1/2013)

(2012) Peter Gölitz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A novel class of sugar-based ether-linked-dispirooxindolo-pyrrolidines/pyrrolizidines through [3+2]-cycloaddition of azomethine ylides

(2012) Arasappan Hemamalini et al.   CARBOHYDRATE RESEARCH

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereodivergent Synthesis of 3-Spirocyclopropyl-2-oxindoles through Direct Enantioselective Cyclopropanation of Oxindoles

(2012) Xiaowei Dou et al.   CHEMISTRY-A EUROPEAN JOURNAL

“Organo-Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′-Pyrrolidinyl Mono- and Bi-spirooxindole Frameworks

(2012) Yi-Ming Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Alum (KAl(SO4)2·12H2O) Catalyzed Multicomponent Transformation: Simple, Efficient, and Green Route to Synthesis of Functionalized Spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones in Ionic Liquid Media

(2012) Mojtaba Mirhosseini Moghaddam et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity

(2012) Gangaru Bhaskar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Construction of Spiro[2H-pyran-3,4′-indoline] by a Systematic Michael/Reduction/Cyclization Sequence Triggered by the Asymmetric Conjugate Addition of Ketones to Isatylidenemalononitriles

(2012) Hua Zhao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Experimental and theoretical approaches to [1,5]-prototropic generation of an azomethine ylide and a 1,3-dipolar cycloaddition for novel spiropyrrolidine oxindoles synthesis

(2012) Yaghoub Sarrafi et al.   JOURNAL OF MOLECULAR STRUCTURE

Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Morita–Baylis–Hillman Carbonates of Isatins with N-Phenylmaleimide Catalyzed by Me-DuPhos

(2012) Yan Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Non-Catalytic Thermal Multicomponent Assembling of Isatin, Cyclic CH-Acids and Malononitrile: An Efficient Approach to Spirooxindole Scaffold

(2012) Michail N. Elinson et al.   MENDELEEV COMMUNICATIONS

Assembly of Spirooxindole Derivatives via Organocatalytic Iminium-Enamine Cascade Reactions

(2012) Klaus Albertshofer et al.   ORGANIC LETTERS

Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

(2012) Edward Richmond et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles

(2012) Ding Du et al.   ORGANIC LETTERS

Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines

(2012) Kun Jiang et al.   ORGANIC LETTERS

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic Michael–Henry Cascade Reactions

(2012) Klaus Albertshofer et al.   ORGANIC LETTERS

Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro[imidazolidine-2-thione]bisoxindoles

(2012) Yan-Yan Han et al.   ORGANIC LETTERS

FeCl3-Catalyzed Stereoselective Construction of Spirooxindole Tetrahydroquinolines via Tandem 1,5-Hydride Transfer/Ring Closure

(2012) Yan-Yan Han et al.   ORGANIC LETTERS

Spiroindolines Identify the Vesicular Acetylcholine Transporter as a Novel Target for Insecticide Action

(2012) Ann Sluder et al.   PLoS One

Investigation of regioselectivity in the synthesis of spiro [pyrrolidine-2,3′-oxindoles] by use of the Huisgen reaction

(2012) Gang Chen et al.   RESEARCH ON CHEMICAL INTERMEDIATES

A one-pot, three-component synthesis of spiro[indoline-isoxazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]triones in water

(2012) Abbas Rahmati et al.   TETRAHEDRON

Synthesis of new enantiomerically pure spirooxindolopyrrolizidines via a three-component asymmetric 1,3-dipolar cycloaddition reaction of azomethine ylides derived from isatin

(2012) Mohammad Javad Taghizadeh et al.   TETRAHEDRON LETTERS

A novel organocatalytic multi-component reaction: an efficient synthesis of polysubstituted pyrano-fused spirooxindoles

(2012) Zeinab Noroozi Tisseh et al.   TETRAHEDRON LETTERS

Ionic liquid mediated 1,3-dipolar cycloaddition of azomethine ylides: a facile and green synthesis of novel dispiro heterocycles

(2012) Renuka Jain et al.   TETRAHEDRON LETTERS

Synthesis of novel dispiro-oxindoles via 1,3-dipolar cycloaddition reactions of azomethine ylides

(2012) Khalil Al Mamari et al.   TETRAHEDRON LETTERS

One-Pot, Three-Component Synthesis of a Library of Spirooxindole-Pyrimidines Catalyzed by Magnetic Nanoparticle Supported Dodecyl Benzenesulfonic Acid in Aqueous Media

(2012) Jia Deng et al.   ACS Combinatorial Science

Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles

(2011) Bin Tan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring

(2011) Garima Kumari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and QSAR study of novel cytotoxic spiro[3H-indole-3,2′(1′H)-pyrrolo[3,4-c]pyrrole]-2,3′,5′(1H,2′aH,4′H)-triones

(2011) Adel S. Girgis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An efficient one-pot three-component reaction for synthesis of spirooxindole derivatives in water media under catalyst-free condition

(2011) Li-Qin Zhao et al.   HETEROATOM CHEMISTRY

Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3'-oxindole] Compounds

(2011) Gang Chen et al.   HETEROCYCLIC COMMUNICATIONS

Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum

(2011) James D. Sunderhaus et al.   ISRAEL JOURNAL OF CHEMISTRY

An efficient one-pot synthesis of dispiropyrrolidine derivatives through 1,3-dipolar cycloaddition reactions under ultrasound irradiation

(2011) Hai Liu et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Highly Efficient Hydrogen-Bonding Catalysis of the Diels–Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeletons

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

(2011) Yong-Mei Xie et al.   MOLECULES

Luminescent bichromophoric spiroindolones – synthesis and electronic properties

(2011) Jan Schönhaber et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

Concise, Stereocontrolled Synthesis of the Citrinadin B Core Architecture

(2011) Carlos A. Guerrero et al.   ORGANIC LETTERS

Highly Stereoselective Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans

(2011) Jingqi Wang et al.   ORGANIC LETTERS

Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-N-Anilides

(2011) Ioulia Gorokhovik et al.   ORGANIC LETTERS

Highly Enantioselective One-Pot Synthesis of Spirocyclopentaneoxindoles Containing the Oxime Group by Organocatalyzed Michael Addition/ISOC/Fragmentation Sequence

(2011) Xiang Li et al.   ORGANIC LETTERS

Tertiary Amine-Catalyzed Chemoselective and Asymmetric [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates of Isatins with Propargyl Sulfones

(2011) Jing Peng et al.   ORGANIC LETTERS

A [3 + 2] Dipolar Cycloaddition Route to 3-Hydroxy-3-alkyl Oxindoles: An Approach to Pyrrolidinoindoline Alkaloids

(2011) Anand Singh et al.   ORGANIC LETTERS

Flexible Strategy for Syntheses of Spirooxindoles using Palladium-Catalyzed Carbosilylation and Sakurai-Type Cyclization

(2011) Sudhir M. Hande et al.   ORGANIC LETTERS

Synthesis of New Spiro[1,4,2-dioxazole-5,3′-indolin]-2′-one by 1,3-Dipolar Cycloaddition

(2011) Rachid Bouhfid et al.   SYNTHETIC COMMUNICATIONS

Solvent-Free One-Pot Synthesis of Spiro[indoline-3,4′(1H′)-pyrano[2,3-c]pyrazol]-2-one Derivatives by Grinding

(2011) Ying Liu et al.   SYNTHETIC COMMUNICATIONS

Facile Three-Component Synthesis of Spirooxindolepyrrololine Ring Systems via 1,3-Dipolar Cycloaddition with 1,4-Naphthoquinone

(2011) Hua Chen et al.   SYNTHETIC COMMUNICATIONS

Simple and Efficient Method for Three-Component Synthesis of Spirooxindoles in Aqueous and Solvent-Free Media

(2011) Akbar Mobinikhaledi et al.   SYNTHETIC COMMUNICATIONS

Efficient one-pot synthesis of spiro[indoline-3,4′-pyrazolo[3,4-e][1,4]thiazepine]dione via three-component reaction

(2011) Hui Chen et al.   TETRAHEDRON

Ambient synthesis of spiro[4H-pyran-oxindole] derivatives under [BMIm]BF4 catalysis

(2011) Kurosh Rad-Moghadam et al.   TETRAHEDRON

Novel four-component route to the synthesis of spiro[indoline-3,4′-pyridine]-3′-carboxylate derivatives

(2011) Abdolali Alizadeh et al.   TETRAHEDRON

An efficient synthesis of pyrazolo[3,4-b]pyridine-4-spiroindolinones by a three-component reaction of 5-aminopyrazoles, isatin, and cyclic β-diketones

(2011) Jairo Quiroga et al.   TETRAHEDRON LETTERS

Direct construction of novel dispiro heterocycles through 1,3-dipolar cycloaddition of azomethine ylides

(2011) Anshu Dandia et al.   TETRAHEDRON LETTERS

A facile strategy for the one pot multicomponent synthesis of spiro dihydropyridines from amines and activated alkynes

(2011) Selvarangam E. Kiruthika et al.   TETRAHEDRON LETTERS

Efficient synthesis of spiroisoxazoline oxindoles

(2011) Carlos J.A. Ribeiro et al.   TETRAHEDRON LETTERS

An expedient diastereoselective synthesis of pyrrolidinyl spirooxindoles fused to sugar lactone via [3+2] cycloaddition of azomethine ylides

(2011) J. Naga Siva Rao et al.   TETRAHEDRON LETTERS

A facile and efficient ultrasound-assisted synthesis of novel dispiroheterocycles through 1,3-dipolar cycloaddition reactions

(2011) Yu Hu et al.   ULTRASONICS SONOCHEMISTRY

Rapid and Efficient Ultrasound-Assisted Method for the Combinatorial Synthesis of Spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives

(2011) Yi Zou et al.   ACS Combinatorial Science

Organocatalytic asymmetric Henry reaction of isatins: Highly enantioselective synthesis of 3-hydroxy-2-oxindoles

(2011) Yong Zhang et al.   RSC Advances

Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of theMycobacterium tuberculosisProtein Tyrosine Phosphatase B

(2010) Viktor V. Vintonyak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation

(2010) Shanmugavel Uma Maheswari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction

(2010) Xavier Companyó et al.   CHEMICAL COMMUNICATIONS

4-hydroxy-2-quinolones 172*. Synthesis and structure of 4,3'-spiro[(6-allyl-2-amino- 5-oxo-5,6-dihydro-4h-pyrano- [3,2-c]quinoline-3-carbo- nitrile)-2'-oxindole]

(2010) I. V. Ukrainets et al.   Chemistry of Heterocyclic Compounds

Domino Pd-Catalyzed Heck Cyclization and Bismuth-Catalyzed Hydroamination: Formal Synthesis of Elacomine and Isoelacomine

(2010) Haruhi Kamisaki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

(2010) Kun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Domino Process to Spirooxindoles: Ligand Effect on Aminopalladation versus Carbopalladation

(2010) Stéphanie Jaegli et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic [3+2] Cyclisation Strategy for the Highly Enantioselective Synthesis of Spirooxindoles

(2010) Arnaud Voituriez et al.   CHEMISTRY-A EUROPEAN JOURNAL

A simple and catalyst-free three-component method for the synthesis of spiro[indenopyrazolopyridine indoline]diones and spiro[indenopyridopyrimidine indoline]triones

(2010) Ghazaleh Imani Shakibaei et al.   COMPTES RENDUS CHIMIE

Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines

(2010) K. Karthikeyan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regioselective Synthesis of Novel Spiropyrrolidines and Spirothiapyrrolizidines Through Multicomponent 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylides

(2010) Hai Liu et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

One-pot synthesis of new spiro[cyclopropane-1,3′-[3H]indol]-2′(1′H)-ones from 3-phenacylideneoxindoles

(2010) Masoud Shaabanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

One-pot and three-component synthesis of spiro[chromeno[2,3-d] pyrimidine-5,3′-indoline]-diones and spiro[chromeno[2,3-c] pyrazole-4,3′-indoline]-diones

(2010) Ramin Ghahremanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Identification of the Spiro(oxindole-3,3′-thiazolidine)-Based Derivatives as Potential p53 Activity Modulators

(2010) Isabel Gomez-Monterrey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolution of a Strategy for Total Synthesis of the Marine Fungal Alkaloid (±)-Communesin F

(2010) Jae Hong Seo et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-Catalyzed Assembly of Spirooxindole Natural Products: A Short Synthesis of Horsfiline

(2010) Nina Deppermann et al.   JOURNAL OF ORGANIC CHEMISTRY

Tandem Intramolecular Photocycloaddition−Retro-Mannich Fragmentation as a Route to Spiro[pyrrolidine-3,3′-oxindoles]. Total Synthesis of (±)-Coerulescine, (±)-Horsfiline, (±)-Elacomine, and (±)-6-Deoxyelacomine

(2010) James D. White et al.   JOURNAL OF ORGANIC CHEMISTRY

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Pyrrolizidine Derivatives in Ionic Liquid [bmim] Br

(2010) Laleh Faraji et al.   LETTERS IN ORGANIC CHEMISTRY

Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif

(2010) Kun Jiang et al.   ORGANIC LETTERS

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles

(2010) Bo Liang et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Highly Enantioselective Construction of Spiro[4H-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

(2010) Wen-Bing Chen et al.   ORGANIC LETTERS

Palladium-Catalyzed Carbo-Heterofunctionalization of Alkenes for the Synthesis of Oxindoles and Spirooxindoles

(2010) Stéphanie Jaegli et al.   ORGANIC LETTERS

Titanium-Catalyzed Stereoselective Synthesis of Spirooxindole Oxazolines

(2010) Joseph J. Badillo et al.   ORGANIC LETTERS

Synthesis of Novel Spiroheterocycles Through 1,3-Dipolar Cycloaddition of Azomethine Ylides with Triarylideneacetylacetone Through Decarboxylation

(2010) Ramalingam Murugan et al.   SYNTHETIC COMMUNICATIONS

A facile synthesis of chromeno[3,4-c]spiropyrrolidine-oxindoles via 1,3-dipolar cycloadditions

(2010) Mehdi Ghandi et al.   TETRAHEDRON

The spiropiperidine-3,3′-oxindole scaffold: a type II β-turn peptide isostere

(2010) Giordano Lesma et al.   TETRAHEDRON

Palladium-catalyzed domino Heck/cyanation: synthesis of 3-cyanomethyloxindoles and their conversion to spirooxoindoles

(2010) Stéphanie Jaegli et al.   TETRAHEDRON

An experimental and theoretical investigation of the regio- and stereoselectivity of the polar [3+2] cycloaddition of azomethine ylides to nitrostyrenes

(2010) Kamal Alimohammadi et al.   TETRAHEDRON

Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition

(2010) Abhijit Hazra et al.   TETRAHEDRON LETTERS

Diastereoselective synthesis of strained spiro-cyclopropanooxindoles from cyclic diazoamides

(2010) Sengodagounder Muthusamy et al.   TETRAHEDRON LETTERS

Simple Three-Component Method for the Synthesis of Spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines

(2010) Ghazaleh Imani Shakibaei et al.   ACS Combinatorial Science

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2-(Substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: Synthesis and anticancer activity

(2009) Peter Kutschy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

(2009) Ramalingam Murugan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficient Synthesis of Spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones by a One-Pot and Three-Component Reaction

(2009) Khosrow Jadidi et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Novel One-Pot, Three-Component Synthesis of Spiro[Indoline-pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]trione Library

(2009) Ramin Ghahremanzadeh et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

An efficient, three-component synthesis of spiro[benzo[g]chromene-4,3′-indoline]-3-carbonitrile and spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine]-6′-carbonitrile derivatives

(2009) Ramin Ghahremanzadeh et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

(2009) Shanghai Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

(2009) Shu-Ming Li   NATURAL PRODUCT REPORTS

Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations

(2009) M. Paola Castaldi et al.   ORGANIC LETTERS

Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5 + 2]-Annulation of Chiral Silyl Alcohols

(2009) Yun Zhang et al.   ORGANIC LETTERS

Synthesis of fused 2′-amino-3′-R-spiro-[indole-3,4′-pyran]-2(1H)-ones

(2009) L. A. Shemchuk et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Spirooxindoles: reaction of 2,6-diaminopyrimidin-4(3H)-one and isatins

(2009) Khosrow Jadidi et al.   TETRAHEDRON

Synthesis of spiro[benzopyrazolonaphthyridine-indoline]-diones and spiro[chromenopyrazolopyridine-indoline]-diones by one-pot, three-component methods in water

(2009) Somayeh Ahadi et al.   TETRAHEDRON

Sodium stearate-catalyzed multicomponent reactions for efficient synthesis of spirooxindoles in aqueous micellar media

(2009) Li-Min Wang et al.   TETRAHEDRON

Pd-catalyzed intramolecular amidation of 2-(buta-1,3-dienyl)phenylcarbamoyl chloride: a concise synthesis of spiro[indoline-3,3′-pyrrolidine]

(2009) Haruhi Kamisaki et al.   TETRAHEDRON LETTERS

Grindstone chemistry: one-pot synthesis of spiro[diindenopyridine-indoline]triones and spiro[acenaphthylene-diindenopyridine]triones

(2009) Ramin Ghahremanzadeh et al.   TETRAHEDRON LETTERS

An expedient approach for the synthesis of dispiropyrrolidine bisoxindoles, spiropyrrolidine oxindoles and spiroindane-1,3-diones through 1,3-dipolar cycloaddition reactions

(2009) Neelakandan Vidhya Lakshmi et al.   TETRAHEDRON LETTERS

Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal (−)-Stephacidin A and (+)-Notoamide B fromAspergillus versicolor NRRL 35600

(2008) Thomas J. Greshock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective synthesis and stereochemical structure of anti-tumor active dispiro[3H-indole-3,2′-pyrrolidine-3′,3″-piperidine]-2(1H),4″-diones

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Versatile Three-Component Procedure for Combinatorial Synthesis of 2-Aminospiro[(3′H)-indol-3′,4-(4H)-pyrans]

(2008) Yuri M. Litvinov et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Synthesis of Maremycins A and D1via Cycloaddition of a Nitrone with (E)-3-Ethylidene-1-methylindolin-2-one

(2008) Tohru Ueda et al.   ORGANIC LETTERS

An easy access to novel steroidal dispiropyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides

(2008) A.R. Suresh Babu et al.   TETRAHEDRON LETTERS