Anti‐ HIV ‐1 antibodies trigger non‐lytic complement deposition on infected cells

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity

(2019) Nirmin Alsahafi et al.   Cell Host & Microbe

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

(2019) Marina Caskey et al.   NATURE MEDICINE

Molecular Mechanism of HIV-1 Entry

(2019) Bing Chen   TRENDS IN MICROBIOLOGY

Complement and the Regulation of T Cell Responses

(2018) Erin E. West et al.   Annual Review of Immunology

Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells

(2018) Akiko Seki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of HIV-1 Envelope Conformation on ADCC Responses

(2018) Jonathan Richard et al.   TRENDS IN MICROBIOLOGY

Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals

(2018) Jérémie Prévost et al.   VIROLOGY

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

(2018) Jonathan Richard et al.   mBio

Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection

(2018) Yehuda Z. Cohen et al.   Current Opinion in HIV and AIDS

HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies

(2018) Simone I. Richardson et al.   PLoS Pathogens

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies

(2018) Jérémy Dufloo et al.   Retrovirology

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

(2018) Erica N. Borducchi et al.   NATURE

Recent progress in broadly neutralizing antibodies to HIV

(2018) Devin Sok et al.   NATURE IMMUNOLOGY

CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions

(2018) Judd F. Hultquist et al.   Nature Protocols

Antibody-mediated prevention and treatment of HIV-1 infection

(2018) Henning Gruell et al.   Retrovirology

Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner

(2017) Thomas Musich et al.   JOURNAL OF VIROLOGY

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies

(2017) Timothée Bruel et al.   JOURNAL OF VIROLOGY

Comprehensive Cross-Clade Characterization of Antibody-Mediated Recognition, Complement-Mediated Lysis, and Cell-Mediated Cytotoxicity of HIV-1 Envelope-Specific Antibodies toward Eradication of the HIV-1 Reservoir

(2017) Shariq Mujib et al.   JOURNAL OF VIROLOGY

Structural insight into proteolytic activation and regulation of the complement system

(2016) Janus A. Schatz-Jakobsen et al.   IMMUNOLOGICAL REVIEWS

Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies

(2016) Benjamin von Bredow et al.   JOURNAL OF VIROLOGY

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

(2016) T. Schoofs et al.   SCIENCE

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

HIV-1 Nef: Taking Control of Protein Trafficking

(2016) Estela A. Pereira et al.   TRAFFIC

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

(2016) Timothée Bruel et al.   Nature Communications

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

(2016) Rob N. de Jong et al.   PLOS BIOLOGY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells

(2015) Kai Yang et al.   JOURNAL OF VIROLOGY

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

Provirus Activation Plus CD59 Blockage Triggers Antibody-Dependent Complement-Mediated Lysis of Latently HIV-1–Infected Cells

(2014) Jie Lan et al.   JOURNAL OF IMMUNOLOGY

HIV-1 Vpu Antagonism of Tetherin Inhibits Antibody-Dependent Cellular Cytotoxic Responses by Natural Killer Cells

(2014) R. A. Alvarez et al.   JOURNAL OF VIROLOGY

The HIV-1 gp120 CD4-Bound Conformation Is Preferentially Targeted by Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Sera from HIV-1-Infected Individuals

(2014) Maxime Veillette et al.   JOURNAL OF VIROLOGY

Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity

(2014) J. F. Arias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

(2014) Tram NQ Pham et al.   Retrovirology

Intracellular sensing of complement C3 activates cell autonomous immunity

(2014) J. C. H. Tam et al.   SCIENCE

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Antibody B cell responses in HIV-1 infection

(2014) Hugo Mouquet   TRENDS IN IMMUNOLOGY

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity

(2013) M. Veillette et al.   JOURNAL OF VIROLOGY

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

(2013) Jean-Philippe Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyreactive Antibodies Plus Complement Enhance the Phagocytosis of Cells Made Apoptotic by UV-Light or HIV

(2013) Zhao-hua Zhou et al.   Scientific Reports

Regulation of Humoral Immunity by Complement

(2012) Michael C. Carroll et al.   IMMUNITY

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

(2011) Z. Zhu et al.   JOURNAL OF VIROLOGY

Emerging role for complement in HIV infection

(2011) Georg Huber et al.   Current Opinion in HIV and AIDS

Human anti–HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness

(2010) John Pietzsch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies

(2008) M. Dechant et al.   CANCER RESEARCH