HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies

Survivors Remorse: antibody-mediated protection against HIV-1

(2017) George K. Lewis et al.   IMMUNOLOGICAL REVIEWS

Diversification of IgG effector functions

(2017) Stylianos Bournazos et al.   INTERNATIONAL IMMUNOLOGY

Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles

(2017) Eric P. Brown et al.   JOURNAL OF IMMUNOLOGICAL METHODS

HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV

(2017) Vijaya Madhavi et al.   JOURNAL OF VIROLOGY

Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner

(2017) Thomas Musich et al.   JOURNAL OF VIROLOGY

V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144

(2017) Lautaro G. Perez et al.   PLoS One

Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies

(2017) Jenniffer M. Mabuka et al.   Frontiers in Immunology

Different Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis

(2017) Kazutaka Kitaura et al.   Frontiers in Immunology

Effects of Well-Controlled HIV Infection on Complement Activation and Function

(2016) Alexandria E-B Rossheim et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects

(2016) Yunda Huang et al.   JOURNAL OF IMMUNOLOGY

Macrophage-Mediated Trogocytosis Leads to Death of Antibody-Opsonized Tumor Cells

(2016) R. Velmurugan et al.   MOLECULAR CANCER THERAPEUTICS

Determinants of HIV-1 broadly neutralizing antibody induction

(2016) Peter Rusert et al.   NATURE MEDICINE

CXCL13 is a plasma biomarker of germinal center activity

(2016) Colin Havenar-Daughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Approaches to the induction of HIV broadly neutralizing antibodies

(2016) Penny L. Moore et al.   Current Opinion in HIV and AIDS

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

(2016) Elise Landais et al.   PLoS Pathogens

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

(2016) Margaret E. Ackerman et al.   PLoS Pathogens

Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

(2016) Alison E. Mahan et al.   PLoS Pathogens

Ig Constant Region Effects on Variable Region Structure and Function

(2016) Alena Janda et al.   Frontiers in Microbiology

SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts

(2016) Chaim A. Schramm et al.   Frontiers in Immunology

Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection

(2016) Rena D. Astronomo et al.   EBioMedicine

Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen

(2016) Yariv Mazor et al.   PLoS One

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

(2015) Amy W. Chung et al.   CELL

Passively Acquired Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity in HIV-Infected Infants Is Associated with Reduced Mortality

(2015) Caitlin Milligan et al.   Cell Host & Microbe

The role of Fc receptors in HIV prevention and therapy

(2015) Austin W. Boesch et al.   IMMUNOLOGICAL REVIEWS

Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell–Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification

(2015) M. Christian Tjiam et al.   JOURNAL OF IMMUNOLOGY

Antibody responses to envelope glycoproteins in HIV-1 infection

(2015) Dennis R Burton et al.   NATURE IMMUNOLOGY

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Virological features associated with the development of broadly neutralizing antibodies to HIV-1

(2015) Penny L. Moore et al.   TRENDS IN MICROBIOLOGY

Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees

(2015) Ickwon Choi et al.   PLoS Computational Biology

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

(2015) Sampa Santra et al.   PLoS Pathogens

Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function

(2014) Amy W. Chung et al.   AIDS

Fc -receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments

(2014) R. P. Taylor et al.   BLOOD

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection

(2014) Anne-Sophie Dugast et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HIV-specific antibody-dependent phagocytosis matures during HIV infection

(2014) Fernanda Ana-Sosa-Batiz et al.   IMMUNOLOGY AND CELL BIOLOGY

Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes

(2014) P. V. Beum et al.   JOURNAL OF IMMUNOLOGY

Capacity for Infectious HIV-1 Virion Capture Differs by Envelope Antibody Specificity

(2014) P. Liu et al.   JOURNAL OF VIROLOGY

Early Preservation of CXCR5+ PD-1+ Helper T Cells and B Cell Activation Predict the Breadth of Neutralizing Antibody Responses in Chronic HIV-1 Infection

(2014) K. Cohen et al.   JOURNAL OF VIROLOGY

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies

(2014) Anne-Sophie Dugast et al.   PLoS One

Transplanting Supersites of HIV-1 Vulnerability

(2014) Tongqing Zhou et al.   PLoS One

Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

(2014) A. W. Chung et al.   Science Translational Medicine

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

(2014) N. L. Yates et al.   Science Translational Medicine

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

(2013) Florian Klein et al.   CELL

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

(2013) Margaret E. Ackerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Divergent Antibody Subclass and Specificity Profiles but Not Protective HLA-B Alleles Are Associated with Variable Antibody Effector Function among HIV-1 Controllers

(2013) J. I. Lai et al.   JOURNAL OF VIROLOGY

Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for Fc R2a and Fc R2b

(2013) M. E. Ackerman et al.   JOURNAL OF VIROLOGY

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

(2013) G. D. Tomaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to ‘protective’ human leukocyte antigen-B alleles in HIV controllers

(2012) Martyn A. French et al.   AIDS

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MEGA-CC: computing core of molecular evolutionary genetics analysis program for automated and iterative data analysis

(2012) S. Kumar et al.   BIOINFORMATICS

Properties of mouse and human IgG receptors and their contribution to disease models

(2012) P. Bruhns   BLOOD

Regulation of Humoral Immunity by Complement

(2012) Michael C. Carroll et al.   IMMUNITY

Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice

(2012) Peter Boross et al.   IMMUNOLOGY LETTERS

High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples

(2012) Eric P. Brown et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family

(2012) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

(2012) D. Tudor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation

(2011) Donald N. Forthal et al.   AIDS

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

(2011) Justin Pollara et al.   CYTOMETRY PART A

The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection

(2011) E. S. Gray et al.   JOURNAL OF VIROLOGY

Isolation of a Monoclonal Antibody That Targets the Alpha-2 Helix of gp120 and Represents the Initial Autologous Neutralizing-Antibody Response in an HIV-1 Subtype C-Infected Individual

(2011) E. S. Gray et al.   JOURNAL OF VIROLOGY

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

(2011) D. R. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals

(2011) Anne-Sophie Dugast et al.   VIROLOGY

Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes

(2010) Sari Iwasaki et al.   CYTOMETRY PART A

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Direction of Plasma Membrane Exchange between Lymphocytes and Accessory Cells by Trogocytosis Is Influenced by the Nature of the Accessory Cell

(2010) Sandrine Daubeuf et al.   JOURNAL OF IMMUNOLOGY

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers

(2009) Olivier Lambotte et al.   AIDS

A comparison of random forest and its Gini importance with standard chemometric methods for the feature selection and classification of spectral data

(2009) Bjoern H Menze et al.   BMC BIOINFORMATICS

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Functional and clinical consequences of Fc receptor polymorphic and copy number variants

(2009) S. Bournazos et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression

(2009) A. Piantadosi et al.   JOURNAL OF VIROLOGY

Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?

(2009) Leonidas Stamatatos et al.   NATURE MEDICINE

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection

(2008) D. N. Sather et al.   JOURNAL OF VIROLOGY

Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals

(2008) Y. Li et al.   JOURNAL OF VIROLOGY

Establishing a Cohort at High Risk of HIV Infection in South Africa: Challenges and Experiences of the CAPRISA 002 Acute Infection Study

(2008) Francois van Loggerenberg et al.   PLoS One