Journal
TRENDS IN MICROBIOLOGY
Volume 26, Issue 4, Pages 253-265Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.10.007
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Funding
- CIHR foundation [352417]
- amfAR Innovation Grant [109343-59-RGRL]
- FAIR
- Canada Research Chair on Retroviral Entry
- Mathilde Krim Fellowship in Basic Biomedical Research from amfAR
- CIHR Fellowship Award
- King Abdullah scholarship for higher education from the Saudi Government
- FRSQ postdoctoral fellowship award
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HIV-1 envelope glycoproteins (Env) represent the only virus-specific antigen exposed at the surface of infected cells. In its unliganded form, Env from primary viruses samples a 'closed' conformation (State 1), which is preferentially recognized by broadly neutralizing antibodies (bNAbs). CD4 engagement drives Env into an intermediate 'partially open' (State 2) and then into the 'open' CD4-bound conformation (State 3). Emerging evidence suggests a link between Env conformation and Ab-dependent cellular cytotoxicity (ADCC). HIV-1-infected cells exposing Env in the CD4-bound conformation are susceptible to ADCC mediated by CD4-induced Abs and HIV + sera. Cells exposing State 1 Env are susceptible to ADCC mediated by bNAbs. Here, we discuss how Env conformation affects ADCC responses and in vitro measurements.
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