HIV-1 cell-to-cell transmission and broadly neutralizing antibodies

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

Impact of HIV-1 Envelope Conformation on ADCC Responses

(2018) Jonathan Richard et al.   TRENDS IN MICROBIOLOGY

Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV-1-infected individuals

(2018) Jérémie Prévost et al.   VIROLOGY

Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection

(2018) Yehuda Z. Cohen et al.   Current Opinion in HIV and AIDS

Anti-HIV-1 antibody-dependent cellular cytotoxicity

(2018) Wen Shi Lee et al.   Current Opinion in HIV and AIDS

Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection

(2018) Fernando Real et al.   Cell Reports

Mechanisms for Cell-to-Cell Transmission of HIV-1

(2018) Lucie Bracq et al.   Frontiers in Immunology

Identification and specificity of broadly neutralizing antibodies against HIV

(2017) Laura E. McCoy et al.   IMMUNOLOGICAL REVIEWS

Combination antiretroviral therapy and cell–cell spread of wild-type and drug-resistant human immunodeficiency virus-1

(2017) Boghuma Kabisen Titanji et al.   JOURNAL OF GENERAL VIROLOGY

HIV Fusion in Dendritic Cells Occurs Mainly at the Surface and Is Limited by Low CD4 Levels

(2017) Lise Chauveau et al.   JOURNAL OF VIROLOGY

T Cell-Macrophage Fusion Triggers Multinucleated Giant Cell Formation for HIV-1 Spreading

(2017) Lucie Bracq et al.   JOURNAL OF VIROLOGY

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies

(2017) Timothée Bruel et al.   JOURNAL OF VIROLOGY

Reduced Potency and Incomplete Neutralization of Broadly Neutralizing Antibodies against Cell-to-Cell Transmission of HIV-1 with Transmitted Founder Envs

(2017) Hongru Li et al.   JOURNAL OF VIROLOGY

Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells

(2017) Yehuda Z. Cohen et al.   JOURNAL OF VIROLOGY

Early antibody therapy can induce long-lasting immunity to SHIV

(2017) Yoshiaki Nishimura et al.   NATURE

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

(2017) Marina Caskey et al.   NATURE MEDICINE

Mapping the human DC lineage through the integration of high-dimensional techniques

(2017) Peter See et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection

(2017) Matthew S. Parsons et al.   Science Translational Medicine

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1

(2017) Jason E. Hammonds et al.   PLoS Pathogens

They Might Be Giants: Does Syncytium Formation Sink or Spread HIV Infection?

(2017) Alex A. Compton et al.   PLoS Pathogens

Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells

(2016) Mickaël M. Ménager et al.   CELL

Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages

(2016) Michihiro Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies

(2016) Benjamin von Bredow et al.   JOURNAL OF VIROLOGY

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

(2016) Johannes F. Scheid et al.   NATURE

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

(2016) T. Schoofs et al.   SCIENCE

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

(2016) R. Kong et al.   SCIENCE

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

(2016) Timothée Bruel et al.   Nature Communications

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

(2016) Kenneth M. Law et al.   Cell Reports

HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell

(2016) Mikaël Boullé et al.   PLoS Pathogens

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

(2016) Marit J. van Gils et al.   Nature Microbiology

HIV-1 Cell-to-Cell Transmission and Antiviral Strategies: An Overview

(2015) Nicoletta Casartelli   CURRENT DRUG TARGETS

SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells

(2015) Diana Ayinde et al.   JOURNAL OF VIROLOGY

HIV-1 Cell-Free and Cell-to-Cell Infections Are Differentially Regulated by Distinct Determinants in the Env gp41 Cytoplasmic Tail

(2015) Natasha D. Durham et al.   JOURNAL OF VIROLOGY

Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission

(2015) Randi B. Gombos et al.   JOURNAL OF VIROLOGY

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

(2015) Marina Caskey et al.   NATURE

Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein

(2015) J. Chen et al.   SCIENCE

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

(2015) Rebecca M. Lynch et al.   Science Translational Medicine

CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies

(2015) Hisashi Akiyama et al.   PLoS Pathogens

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent

(2015) Lucia Reh et al.   PLoS Pathogens

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

(2014) Alex A. Compton et al.   Cell Host & Microbe

Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells

(2014) Amy E. Baxter et al.   Cell Host & Microbe

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

(2014) Masashi Shingai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1 Entry in SupT1-R5, CEM-ss, and Primary CD4+ T Cells Occurs at the Plasma Membrane and Does Not Require Endocytosis

(2014) N. Herold et al.   JOURNAL OF VIROLOGY

Ezrin Is a Component of the HIV-1 Virological Presynapse and Contributes to the Inhibition of Cell-Cell Fusion

(2014) N. H. Roy et al.   JOURNAL OF VIROLOGY

Broadly Neutralizing Antibody VRC01 Prevents HIV-1 Transmission from Plasmacytoid Dendritic Cells to CD4 T Lymphocytes

(2014) B. Su et al.   JOURNAL OF VIROLOGY

Neutralisation of HIV-1 cell-cell spread by human and llama antibodies

(2014) Laura E McCoy et al.   Retrovirology

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

(2014) Kevin Tartour et al.   Retrovirology

Antibody B cell responses in HIV-1 infection

(2014) Hugo Mouquet   TRENDS IN IMMUNOLOGY

Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue

(2014) Mark S. Ladinsky et al.   PLoS Pathogens

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

(2013) Marine Malbec et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

(2013) D. Kolodkin-Gal et al.   JOURNAL OF VIROLOGY

High-Multiplicity HIV-1 Infection and Neutralizing Antibody Evasion Mediated by the Macrophage-T Cell Virological Synapse

(2013) C. J. A. Duncan et al.   JOURNAL OF VIROLOGY

Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity

(2013) M. Veillette et al.   JOURNAL OF VIROLOGY

Productive Entry of HIV-1 during Cell-to-Cell Transmission via Dynamin-Dependent Endocytosis

(2013) R. D. Sloan et al.   JOURNAL OF VIROLOGY

Clustering and Mobility of HIV-1 Env at Viral Assembly Sites Predict Its Propensity To Induce Cell-Cell Fusion

(2013) N. H. Roy et al.   JOURNAL OF VIROLOGY

Dynamics of HIV-Containing Compartments in Macrophages Reveal Sequestration of Virions and Transient Surface Connections

(2013) Raphaël Gaudin et al.   PLoS One

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

(2013) J. A. Horwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer

(2013) Marine Malbec et al.   Retrovirology

The infectious synapse formed between mature dendritic cells and CD4+ T cells is independent of the presence of the HIV-1 envelope glycoprotein

(2013) Maria T Rodriguez-Plata et al.   Retrovirology

Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies

(2013) Torben Schiffner et al.   VACCINE

Multiple proviral integration events after virological synapse-mediated HIV-1 spread

(2013) Rebecca A. Russell et al.   VIROLOGY

Semen CD4+ T Cells and Macrophages Are Productively Infected at All Stages of SIV infection in Macaques

(2013) Sibylle Bernard-Stoecklin et al.   PLoS Pathogens

Interferon-Inducible Mechanism of Dendritic Cell-Mediated HIV-1 Dissemination Is Dependent on Siglec-1/CD169

(2013) Wendy Blay Puryear et al.   PLoS Pathogens

Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes

(2012) B. Su et al.   BLOOD

Innate Immune Sensing of HIV-1 by Dendritic Cells

(2012) Jeremy Luban   Cell Host & Microbe

Transmembrane Domain Membrane Proximal External Region but Not Surface Unit–Directed Broadly Neutralizing HIV-1 Antibodies Can Restrict Dendritic Cell–Mediated HIV-1 Trans-infection

(2012) Manish Sagar et al.   JOURNAL OF INFECTIOUS DISEASES

HIV Cell-to-Cell Transmission Requires the Production of Infectious Virus Particles and Does Not Proceed through Env-Mediated Fusion Pores

(2012) B. Monel et al.   JOURNAL OF VIROLOGY

Neutralization Resistance of Virological Synapse-Mediated HIV-1 Infection Is Regulated by the gp41 Cytoplasmic Tail

(2012) N. D. Durham et al.   JOURNAL OF VIROLOGY

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Cell-Free (RNA) and Cell-Associated (DNA) HIV-1 and Postnatal Transmission through Breastfeeding

(2012) James Ndirangu et al.   PLoS One

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy

(2012) J. Chojnacki et al.   SCIENCE

In vivo imaging of virological synapses

(2012) Xaver Sewald et al.   Nature Communications

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

(2012) Nuria Izquierdo-Useros et al.   PLOS BIOLOGY

Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells

(2012) Anupriya Aggarwal et al.   PLoS Pathogens

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies

(2012) Irene A. Abela et al.   PLoS Pathogens

HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation

(2011) D. S. Nikolic et al.   BLOOD

Cell-to-Cell Transfer of HIV-1 via Virological Synapses Leads to Endosomal Virion Maturation that Activates Viral Membrane Fusion

(2011) Benjamin M. Dale et al.   Cell Host & Microbe

Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection

(2011) Irena Kadiu et al.   Journal of Neuroimmune Pharmacology

Macrophage Bridging Conduit Trafficking of HIV-1 Through the Endoplasmic Reticulum and Golgi Network

(2011) Irena Kadiu et al.   JOURNAL OF PROTEOME RESEARCH

Multiploid Inheritance of HIV-1 during Cell-to-Cell Infection

(2011) A. Del Portillo et al.   JOURNAL OF VIROLOGY

Macrophage Internal HIV-1 Is Protected from Neutralizing Antibodies

(2011) H. Koppensteiner et al.   JOURNAL OF VIROLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Tetherin restricts direct cell-to-cell infection of HIV-1

(2011) Björn D Kuhl et al.   Retrovirology

A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity

(2011) Sonsoles Sánchez-Palomino et al.   VACCINE

Nef Decreases HIV-1 Sensitivity to Neutralizing Antibodies that Target the Membrane-proximal External Region of TMgp41

(2011) Rachel P.J. Lai et al.   PLoS Pathogens

Maturation-Induced Cloaking of Neutralization Epitopes on HIV-1 Particles

(2011) Amanda S. Joyner et al.   PLoS Pathogens

The Regulated Secretory Pathway in CD4+ T cells Contributes to Human Immunodeficiency Virus Type-1 Cell-to-Cell Spread at the Virological Synapse

(2011) Clare Jolly et al.   PLoS Pathogens

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

(2010) Claudia Haller et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Infection of Macaques after Vaginal Exposure to Cell‐Associated Simian Immunodeficiency Virus

(2010) Bettina Sallé et al.   JOURNAL OF INFECTIOUS DISEASES

Virological Synapse-Mediated Spread of Human Immunodeficiency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition

(2010) N. Martin et al.   JOURNAL OF VIROLOGY

Cell-Cell Spread of Human Immunodeficiency Virus Type 1 Overcomes Tetherin/BST-2-Mediated Restriction in T cells

(2010) C. Jolly et al.   JOURNAL OF VIROLOGY

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse

(2010) Gaia Vasiliver-Shamis et al.   Viruses-Basel

Tetherin Restricts Productive HIV-1 Cell-to-Cell Transmission

(2010) Nicoletta Casartelli et al.   PLoS Pathogens

Formation of Syncytia Is Repressed by Tetraspanins in Human Immunodeficiency Virus Type 1-Producing Cells

(2009) J. Weng et al.   JOURNAL OF VIROLOGY

Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses

(2009) D. Rudnicka et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

(2009) M. D. Simek et al.   JOURNAL OF VIROLOGY

Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses

(2009) W. Hubner et al.   SCIENCE

Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells

(2008) Marta Massanella et al.   AIDS

A clathrin–dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell–T cell transmission

(2008) B BOSCH et al.   ANTIVIRAL RESEARCH

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses

(2008) F. Groot et al.   BLOOD

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking

(2008) E.A. Eugenin et al.   CELLULAR IMMUNOLOGY

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia

(2008) G. D. Tomaras et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY

HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4

(2008) Isabel Puigdomenech et al.   Retrovirology

Real-Time Visualization of HIV-1 GAG Trafficking in Infected Macrophages

(2008) Karine Gousset et al.   PLoS Pathogens