Effects of Notch glycosylation on health and diseases

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

(2019) Yuki Hitomi et al.   Scientific Reports

Protein O-glucosylation: another essential role of glucose in biology

(2019) Hongjun Yu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

(2019) Yoshiki Narimatsu et al.   MOLECULAR CELL

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

(2018) Ikuo K. Suzuki et al.   CELL

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer

(2018) May Chammaa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Comparative genomics reveals that loss of lunatic fringe (LFNG ) promotes melanoma metastasis

(2018) Martin Del Castillo Velasco-Herrera et al.   Molecular Oncology

Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1

(2018) Mitsutaka Ogawa et al.   MOLECULES

Multiple Roles for O-Glycans in Notch Signalling

(2018) Shweta Varshney et al.   FEBS LETTERS

Two novel proteinO-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

(2018) Hideyuki Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening of known disease genes in congenital scoliosis

(2018) Kazuki Takeda et al.   Molecular Genetics & Genomic Medicine

Identification of novel LFNG mutations in spondylocostal dysostosis

(2018) Nao Otomo et al.   JOURNAL OF HUMAN GENETICS

Altered Notch signaling in Dowling-Degos disease: Additional mutations in POGLUT1 and further insights into disease pathogenesis

(2018) Damian J. Ralser et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

(2017) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer

(2017) Heba Allam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Delta-induced Notch signaling using fucose analogs

(2017) Michael Schneider et al.   Nature Chemical Biology

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1)

(2017) Zhijie Li et al.   Nature Communications

Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila

(2017) Tom V. Lee et al.   PLoS Genetics

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss

(2016) Emilia Servián‐Morilla et al.   EMBO Molecular Medicine

Mapping Sites ofO-Glycosylation and Fringe Elongation onDrosophilaNotch

(2016) Beth M. Harvey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Roles ofO-Glucose Glycans Redundant with MonosaccharideO-Fucose on Notch in Notch Trafficking

(2016) Kenjiroo Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

(2016) Hongjun Yu et al.   Nature Chemical Biology

Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia

(2016) Qi Ye et al.   Scientific Reports

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

(2016) Min Zhang et al.   Cancer Medicine

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome

(2015) Josephina A.N. Meester et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

DLL4loss-of-function heterozygous mutations cause Adams-Oliver syndrome

(2015) F. Aminkeng   CLINICAL GENETICS

Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism

(2015) Deepika Vasudevan et al.   CURRENT BIOLOGY

The multiple roles of epidermal growth factor repeatO-glycans in animal development

(2015) Amanda R Haltom et al.   GLYCOBIOLOGY

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy ofPoglut1(Rumi)

(2015) Shakeel M. Thakurdas et al.   HEPATOLOGY

Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism

(2015) Hongjun Yu et al.   Nature Chemical Biology

Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

(2015) S Zhang et al.   ONCOGENE

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2

(2015) Nitya Ramkumar et al.   PLoS Genetics

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

Mutations in NOTCH1 Cause Adams-Oliver Syndrome

(2014) Anna-Barbara Stittrich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in POGLUT1, Encoding Protein O-Glucosyltransferase 1, Cause Autosomal-Dominant Dowling-Degos Disease

(2014) F. Buket Basmanav et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Met and Notch in theLfng-deficient,Met-amplified triple-negative breast cancer

(2014) Shubing Zhang et al.   CANCER BIOLOGY & THERAPY

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

O-Fucose Monosaccharide ofDrosophilaNotch Has a Temperature-sensitive Function and Cooperates withO-Glucose Glycan in Notch Transport and Notch Signaling Activation

(2014) Akira Ishio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer

(2014) Yang Sui Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

(2014) P. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in POFUT1, Encoding Protein O-fucosyltransferase 1, Cause Generalized Dowling-Degos Disease

(2013) Ming Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in EOGT Confirm the Genetic Heterogeneity of Autosomal-Recessive Adams-Oliver Syndrome

(2013) Ranad Shaheen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal recessive Adams–Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase

(2013) Idan Cohen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer

(2013) Lenora W. M. Loo et al.   GENES CHROMOSOMES & CANCER

Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer

(2013) SATOSHI YOKOTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

(2013) Marie Blanke Andrawes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch activation inhibits AML growth and survival: a potential therapeutic approach

(2013) Sankaranarayanan Kannan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality

(2013) Marko T. Boskovski et al.   NATURE

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Notch inhibitors for cancer treatment

(2013) Ingrid Espinoza et al.   PHARMACOLOGY & THERAPEUTICS

The EGF Repeat-Specific O-GlcNAc-Transferase Eogt Interacts with Notch Signaling and Pyrimidine Metabolism Pathways in Drosophila

(2013) Reto Müller et al.   PLoS One

Negative Regulation of Notch Signaling by Xylose

(2013) Tom V. Lee et al.   PLoS Genetics

RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

(2012) Susan J. Hassed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1

(2012) Yuta Sakaidani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer

(2012) Keli Xu et al.   CANCER CELL

Site-specificO-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch

(2012) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

(2012) J. F. Alfaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

(2011) R. Fernandez-Valdivia et al.   DEVELOPMENT

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Molecular Cloning of a Xylosyltransferase That Transfers the Second Xylose toO-Glucosylated Epidermal Growth Factor Repeats of Notch

(2011) Maya K. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1

(2011) Nadia A. Rana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

(2011) H. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

(2011) N. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell–matrix interactions

(2011) Yuta Sakaidani et al.   Nature Communications

Overexpression of Human CAP10-Like Protein 46 KD in T-Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia

(2010) Youxin Wang et al.   Genetic Testing and Molecular Biomarkers

Role of glycosylation of Notch in development

(2010) Hideyuki Takeuchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

(2009) B. J. Wouters et al.   BLOOD

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting onO-Glucosylated Notch Epidermal Growth Factor Repeats

(2009) Maya K. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

Roles of Pofut1 andO-Fucose in Mammalian Notch Signaling

(2008) Mark Stahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors

(2008) Aiko Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE

Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles

(2008) Geneviève Aubin-Houzelstein et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE