Mapping Sites ofO-Glycosylation and Fringe Elongation onDrosophilaNotch

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome

(2015) Josephina A.N. Meester et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

DLL4loss-of-function heterozygous mutations cause Adams-Oliver syndrome

(2015) F. Aminkeng   CLINICAL GENETICS

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy ofPoglut1(Rumi)

(2015) Shakeel M. Thakurdas et al.   HEPATOLOGY

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2

(2015) Nitya Ramkumar et al.   PLoS Genetics

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

Mutations in NOTCH1 Cause Adams-Oliver Syndrome

(2014) Anna-Barbara Stittrich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ImpairedO-LinkedN-Acetylglucosaminylation in the Endoplasmic Reticulum by Mutated Epidermal Growth Factor (EGF) Domain-specificO-LinkedN-Acetylglucosamine Transferase Found in Adams-Oliver Syndrome

(2014) Mitsutaka Ogawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

(2014) P. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

(2014) Lauren LeBon et al.   eLife

Mutations in EOGT Confirm the Genetic Heterogeneity of Autosomal-Recessive Adams-Oliver Syndrome

(2013) Ranad Shaheen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal recessive Adams–Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase

(2013) Idan Cohen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

The EGF Repeat-Specific O-GlcNAc-Transferase Eogt Interacts with Notch Signaling and Pyrimidine Metabolism Pathways in Drosophila

(2013) Reto Müller et al.   PLoS One

Negative Regulation of Notch Signaling by Xylose

(2013) Tom V. Lee et al.   PLoS Genetics

RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

(2012) Susan J. Hassed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1

(2012) Yuta Sakaidani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Site-specificO-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch

(2012) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

(2012) J. F. Alfaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands

(2012) S. Yamamoto et al.   SCIENCE

Notch signaling in human development and disease

(2012) Andrea L. Penton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Multiple O -glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling

(2011) Jessica Leonardi et al.   DEVELOPMENT

Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine

(2011) C. N. Perdigoto et al.   DEVELOPMENT

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

(2011) R. Fernandez-Valdivia et al.   DEVELOPMENT

Molecular Cloning of a Xylosyltransferase That Transfers the Second Xylose toO-Glucosylated Epidermal Growth Factor Repeats of Notch

(2011) Maya K. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1

(2011) Nadia A. Rana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOTCH2mutations in Alagille syndrome

(2011) Binita Maya Kamath et al.   JOURNAL OF MEDICAL GENETICS

O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell–matrix interactions

(2011) Yuta Sakaidani et al.   Nature Communications

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting onO-Glucosylated Notch Epidermal Growth Factor Repeats

(2009) Maya K. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors

(2008) Aiko Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Diversity ofO-Linked Glycans Expressed duringDrosophila melanogasterDevelopment Reflects Stage- and Tissue-specific Requirements for Cell Signaling

(2008) Kazuhiro Aoki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY