Inhibition of Delta-induced Notch signaling using fucose analogs

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway

(2016) Lijie Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mapping Sites ofO-Glycosylation and Fringe Elongation onDrosophilaNotch

(2016) Beth M. Harvey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Notch Signaling as a Therapeutic Approach for Liver Cancer

(2015) Guang Wu et al.   CURRENT GENE THERAPY

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development

(2015) Yinghui Song et al.   JOURNAL OF IMMUNOLOGY

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Notching on Cancer’s Door: Notch Signaling in Brain Tumors

(2015) Marcin Teodorczyk et al.   Frontiers in Oncology

Abstract C158: Tumor-specific inhibition of jagged-dependent notch signaling using a Probody  therapeutic.

(2014) J. Sagert et al.   MOLECULAR CANCER THERAPEUTICS

O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

(2014) Julia Müller et al.   PLoS One

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

(2014) P. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein O-fucosyltransferase 1: A potential diagnostic marker and therapeutic target for human oral cancer

(2013) SATOSHI YOKOTA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

(2013) Marie Blanke Andrawes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of orally active inhibitors of protein and cellular fucosylation

(2013) N. M. Okeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

6-Alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin Type-1 repeats by protein O-fucosyltransferases 1 and 2

(2012) E. Al-Shareffi et al.   GLYCOBIOLOGY

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands

(2012) S. Yamamoto et al.   SCIENCE

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

(2011) I. Van de Walle et al.   BLOOD

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1

(2011) Nadia A. Rana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Structural Insights into the Mechanism of Protein O-Fucosylation

(2011) Erandi Lira-Navarrete et al.   PLoS One

Notch signaling: Emerging molecular targets for cancer therapy

(2010) Ling Yin et al.   BIOCHEMICAL PHARMACOLOGY

Chemical Synthesis, Folding, and Structural Insights intoO-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor

(2010) Kazumi Hiruma-Shimizu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain

(2009) S. Ohata et al.   DEVELOPMENT

Regulation of Notch signaling during T- and B-cell development byO-fucose glycans

(2009) Pamela Stanley et al.   IMMUNOLOGICAL REVIEWS

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

(2009) Michael J. Parsons et al.   MECHANISMS OF DEVELOPMENT

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors

(2008) Aiko Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY