O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila

(2017) Tom V. Lee et al.   PLoS Genetics

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-Glycans in the Ligand-Binding Region

(2016) Shun Hayakawa et al.   BIOCHEMISTRY

A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss

(2016) Emilia Servián‐Morilla et al.   EMBO Molecular Medicine

Mapping Sites ofO-Glycosylation and Fringe Elongation onDrosophilaNotch

(2016) Beth M. Harvey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Roles ofO-Glucose Glycans Redundant with MonosaccharideO-Fucose on Notch in Notch Trafficking

(2016) Kenjiroo Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

(2016) Hongjun Yu et al.   Nature Chemical Biology

ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells

(2016) Ryan P. Berger et al.   STEM CELLS

Peters Plus Syndrome Mutations Disrupt a Noncanonical ER Quality-Control Mechanism

(2015) Deepika Vasudevan et al.   CURRENT BIOLOGY

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

The multiple roles of epidermal growth factor repeatO-glycans in animal development

(2015) Amanda R Haltom et al.   GLYCOBIOLOGY

Glycosylation-directed quality control of protein folding

(2015) Chengchao Xu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Mutations in POGLUT1, Encoding Protein O-Glucosyltransferase 1, Cause Autosomal-Dominant Dowling-Degos Disease

(2014) F. Buket Basmanav et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-Fucose Monosaccharide ofDrosophilaNotch Has a Temperature-sensitive Function and Cooperates withO-Glucose Glycan in Notch Transport and Notch Signaling Activation

(2014) Akira Ishio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

(2014) P. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in POFUT1, Encoding Protein O-fucosyltransferase 1, Cause Generalized Dowling-Degos Disease

(2013) Ming Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Protein Folding in the Endoplasmic Reticulum

(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

Negative Regulation of Notch Signaling by Xylose

(2013) Tom V. Lee et al.   PLoS Genetics

Site-specificO-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch

(2012) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

(2011) R. Fernandez-Valdivia et al.   DEVELOPMENT

Molecular Cloning of a Xylosyltransferase That Transfers the Second Xylose toO-Glucosylated Epidermal Growth Factor Repeats of Notch

(2011) Maya K. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1

(2011) Nadia A. Rana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

(2011) H. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell–matrix interactions

(2011) Yuta Sakaidani et al.   Nature Communications

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting onO-Glucosylated Notch Epidermal Growth Factor Repeats

(2009) Maya K. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

Roles of Pofut1 andO-Fucose in Mammalian Notch Signaling

(2008) Mark Stahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pofut1 is required for the proper localization of the Notch receptor during mouse development

(2008) Yoshiaki Okamura et al.   MECHANISMS OF DEVELOPMENT