β-amyloid and Oxidative Stress: Perspectives in Drug Development

The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease

(2019) Jing Zhi A. Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

(2019) Lei Liu et al.   JOURNAL OF CELL BIOLOGY

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

(2019) Giuseppe Caruso et al.   Cells

Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model

(2019) Christopher Nishioka et al.   NEUROIMAGE

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

(2018) Diego Mastroeni et al.   Alzheimers & Dementia

Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction

(2018) Shuxuan Huang et al.   BRAIN RESEARCH

Tau Proteins and Tauopathies in Alzheimer’s Disease

(2018) Fong Ping Chong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease

(2018) Barbara Mroczko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

An integrated strategy to correlate aggregation state, structure and toxicity of Aß 1–42 oligomers

(2018) Federica Bisceglia et al.   TALANTA

Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells

(2018) Claudia G. Fresta et al.   Cell Death & Disease

The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death

(2018) Sara Merlo et al.   Scientific Reports

Role of Copper in the Onset of Alzheimer’s Disease Compared to Other Metals

(2018) Soghra Bagheri et al.   Frontiers in Aging Neuroscience

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

(2018) Rudimar L. Frozza et al.   Frontiers in Neuroscience

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?

(2018) Sara Merlo et al.   CNS Neuroscience & Therapeutics

The Metal Theory of Alzheimer's Disease

(2018) Ashley I. Bush   JOURNAL OF ALZHEIMERS DISEASE

β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease

(2018) Bruno Herculano et al.   JOURNAL OF ALZHEIMERS DISEASE

Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells

(2018) Giuseppe Caruso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders

(2018) Giuseppe Caruso et al.   PROGRESS IN NEUROBIOLOGY

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

(2018) Mikael Marttinen et al.   Frontiers in Neuroscience

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9

(2017) Simona Federica Spampinato et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

(2017) Chia-Chen Liu et al.   JOURNAL OF NEUROSCIENCE

Carnosine modulates nitric oxide in stimulated murine RAW 264.7 macrophages

(2017) Giuseppe Caruso et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

(2017) Rishika Kundra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective effect of carnosine against salsolinol-induced Parkinson's disease

(2017) Jun Zhao et al.   Experimental and Therapeutic Medicine

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

(2017) Fiona Kerr et al.   PLoS Genetics

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

(2017) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuron Specific Toxicity of Oligomeric Amyloid-β: Role for JUN-Kinase and Oxidative Stress

(2017) Philip J. Ebenezer et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Disease-Induced Neuroinflammation and Depression

(2016) Cristina Benatti et al.   CNS & Neurological Disorders-Drug Targets

Reduction of Oxidative/Nitrosative Stress in Brain and its Involvement in the Neuroprotective Effect of n-3 PUFA in Alzheimer's Disease

(2016) Simona Serini et al.   Current Alzheimer Research

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system

(2016) Banafsheh Amir Aslani et al.   LIFE SCIENCES

Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions

(2016) Giuseppe Caruso et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Biomarkers for the Early Detection and Progression of Alzheimer’s Disease

(2016) Scott E. Counts et al.   Neurotherapeutics

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

(2016) Sumasri Guntupalli et al.   NEURAL PLASTICITY

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

Indirect detection of superoxide in RAW 264.7 macrophage cells using microchip electrophoresis coupled to laser-induced fluorescence

(2015) Richard P. S. de Campos et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effect of Acetyl-l-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat

(2015) Mohammad Reza Sepand et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity

(2015) Sara Merlo et al.   JOURNAL OF NATURAL PRODUCTS

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

(2015) Ildete Luísa Ferreira et al.   NEUROBIOLOGY OF AGING

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease

(2015) Xiaojuan Sun et al.   Frontiers in Pharmacology

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Beta-Amyloid Oligomers Activate Apoptotic BAK Pore for Cytochrome c Release

(2014) Jaewook Kim et al.   BIOPHYSICAL JOURNAL

Free radicals, reactive oxygen species, oxidative stress and its classification

(2014) Volodymyr I. Lushchak   CHEMICO-BIOLOGICAL INTERACTIONS

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease

(2014) Elizabeth Drolle et al.   DRUG METABOLISM REVIEWS

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

The neuroprotective role of catalase overexpression in SH-SY5Y cells against beta-amyloid and H2O2 toxicity

(2013) Amrutha Chilumuri et al.   Alzheimers & Dementia

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

(2013) Laure-Estelle Cassagnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Different effects of Alzheimer's peptide Aβ(1–40) oligomers and fibrils on supported lipid membranes

(2013) Claudio Canale et al.   BIOPHYSICAL CHEMISTRY

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures

(2013) Oddvar Myhre et al.   Oxidative Medicine and Cellular Longevity

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

(2012) Rui O. Costa et al.   AGING CELL

Monitoring intracellular nitric oxide production using microchip electrophoresis and laser-induced fluorescence detection

(2012) Emilie R. Mainz et al.   Analytical Methods

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target

(2012) Peter Faller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives

(2012) Márcio Carocho et al.   FOOD AND CHEMICAL TOXICOLOGY

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Metallostasis and amyloid β-degrading enzymes

(2012) Giuseppe Grasso et al.   Metallomics

Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives

(2012) Daniel Pens Gelain et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Elevation of glutathione as a therapeutic strategy in Alzheimer disease

(2011) Chava B. Pocernich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Copper(I) and Copper(II) Inhibit Aβ Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer’s Disease

(2011) Giuseppe Grasso et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

(2010) Joshua B. Owen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidative and Anti-Inflammatory Protection from Carnosine in the Striatum of MPTP-Treated Mice

(2010) Shih-Jei Tsai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics

(2010) James A. Duce et al.   PROGRESS IN NEUROBIOLOGY

Oligomers of β-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model

(2009) Renee C. Gaspar et al.   EXPERIMENTAL NEUROLOGY

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

(2009) K. Usui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Structure-Function Implications in Alzheimers Disease: Effect of Aβ Oligomers at Central Synapses

(2008) Waldo Cerpa et al.   Current Alzheimer Research

The Cell Cycle Molecules Behind Neurodegeneration in Alzheimers Disease: Perspectives for Drug Development

(2008) A. Copani et al.   CURRENT MEDICINAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Differential neuroprotective effects of carnosine, anserine, andN-acetyl carnosine against permanent focal ischemia

(2008) Jiangyong Min et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Integrins mediate β-amyloid-induced cell-cycle activation and neuronal death

(2007) Giuseppina Frasca et al.   JOURNAL OF NEUROSCIENCE RESEARCH