A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target

Therapeutic Redistribution of Metal Ions To Treat Alzheimer’s Disease

(2012) Peter J. Crouch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols

(2012) Lynne M. Hyman et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer’s Mouse Model

(2012) Johnatan Ceccom et al.   PLoS One

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reevaluation of Copper(I) Affinity for Amyloid-β Peptides by Competition with Ferrozine-An Unusual Copper(I) Indicator

(2011) Bruno Alies et al.   CHEMISTRY-A EUROPEAN JOURNAL

Coordination of zinc ions to the key proteins of neurodegenerative diseases: Aβ, APP, α-synuclein and PrP

(2011) Vello Tõugu et al.   COORDINATION CHEMISTRY REVIEWS

Copper in Alzheimer disease: too much, too little, or misplaced?

(2011) Peter Faller   FREE RADICAL BIOLOGY AND MEDICINE

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease

(2011) Simon A. James et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: a tribute to Moussa Youdim

(2011) Orly Weinreb et al.   JOURNAL OF NEURAL TRANSMISSION

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Two Functions, One Molecule: A Metal-Binding and a Targeting Moiety to Combat Alzheimer's Disease

(2010) Christelle Hureau  et al.   CHEMBIOCHEM

Vitamin E Forms in Alzheimer's Disease: A Review of Controversial and Clinical Experiences

(2010) Owoedimo B. Usoro et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

(2010) Walter E. Müller et al.   MOLECULAR NEUROBIOLOGY

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-  copper complex follow a preorganization mechanism

(2010) V. Balland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

(2008) Gabriele Meloni et al.   Nature Chemical Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Preparation and Study of New Poly-8-Hydroxyquinoline Chelators for an anti-Alzheimer Strategy

(2007) Céline Deraeve et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quantitative imaging of zinc, copper and lead in three distinct regions of the human brain by laser ablation inductively coupled plasma mass spectrometry

(2007) J. Dobrowolska et al.   TALANTA