Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?

Behavioral and psychological symptoms of dementia (BPSD) and impaired cognition reflect unsuccessful neuronal compensation in the pre-plaque stage and serve as early markers for Alzheimer’s disease in the APP23 mouse model

(2018) Anna Pfeffer et al.   BEHAVIOURAL BRAIN RESEARCH

Tau Proteins and Tauopathies in Alzheimer’s Disease

(2018) Fong Ping Chong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A Novel Therapeutic Approach to Treat Alzheimer’s Disease by Neurotrophic Support During the Period of Synaptic Compensation

(2018) Narjes Baazaoui et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of adult hippocampal neurogenesis in brain health and disease

(2018) Tomohisa Toda et al.   MOLECULAR PSYCHIATRY

Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation

(2018) Ivayla Apostolova et al.   NEUROBIOLOGY OF AGING

Resistance vs resilience to Alzheimer disease

(2018) Eider M. Arenaza-Urquijo et al.   NEUROLOGY

The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death

(2018) Sara Merlo et al.   Scientific Reports

Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

(2018) Eiji Kobayashi et al.   Scientific Reports

Effect of Disease Severity on Neural Compensation of Item and Associative Recognition in Mild Cognitive Impairment

(2018) Francis Clément et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer’s Disease: Implications from a Transgenic Mouse Model of the Disease

(2017) Narjes Baazaoui et al.   JOURNAL OF ALZHEIMERS DISEASE

Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation

(2017) Eider M. Arenaza-Urquijo et al.   NEUROBIOLOGY OF AGING

The role of BDNF in Alzheimer's disease

(2017) Heikki Tanila   NEUROBIOLOGY OF DISEASE

Visualizing Hyperactivation in Neurodegeneration Based on Prefrontal Oxygenation: A Comparative Study of Mild Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

(2017) Kah Hui Yap et al.   Frontiers in Aging Neuroscience

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Early ?-Amyloid-induced Synaptic Dysfunction Is Counteracted by Estrogen in Organotypic Hippocampal Cultures

(2016) Sara Merlo et al.   Current Alzheimer Research

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Aberrant Co-localization of Synaptic Proteins Promoted by Alzheimer’s Disease Amyloid-β Peptides: Protective Effect of Human Serum Albumin

(2016) Marta Domínguez-Prieto et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

(2016) M. S. Unger et al.   MOLECULAR NEUROBIOLOGY

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Aberrant expression of the pore-forming KATP channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer’s disease

(2016) Chelsea M. Griffith et al.   NEUROSCIENCE

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

(2016) Peter Koppensteiner et al.   Scientific Reports

Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease

(2015) Auriel A. Willette et al.   DIABETES

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

(2015) Willem Kamphuis et al.   GLIA

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

(2015) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric Oxide Signaling Is Recruited As a Compensatory Mechanism for Sustaining Synaptic Plasticity in Alzheimer's Disease Mice

(2015) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

The brain compensatory mechanisms and Alzheimer′s disease progression: a new protective strategy

(2015) Vasily Vorobyov et al.   Neural Regeneration Research

The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease

(2015) Anita Stargardt et al.   NEUROBIOLOGY OF AGING

Large-Scale Functional Brain Network Abnormalities in Alzheimer’s Disease: Insights from Functional Neuroimaging

(2014) Bradford C. Dickerson et al.   BEHAVIOURAL NEUROLOGY

Compensatory mechanisms in higher-educated subjects with Alzheimer’s disease: a study of 20 years of cognitive decline

(2014) Hélène Amieva et al.   BRAIN

Cortical hypermetabolism in MCI subjects: a compensatory mechanism?

(2014) A. Ashraf et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy

(2014) Jing-Hui Song et al.   MOLECULAR NEUROBIOLOGY

Neural compensation in older people with brain amyloid-β deposition

(2014) Jeremy A Elman et al.   NATURE NEUROSCIENCE

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Protective Effects of Testosterone on Presynaptic Terminals against Oligomericβ-Amyloid Peptide in Primary Culture of Hippocampal Neurons

(2014) Chi-Fai Lau et al.   Biomed Research International

Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking

(2013) Joohyun Park et al.   NEUROBIOLOGY OF DISEASE

Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

(2013) Alice Krezymon et al.   PLoS One

Microglia: An Active Player in the Regulation of Synaptic Activity

(2013) Kyungmin Ji et al.   NEURAL PLASTICITY

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease

(2012) Magdalena Kulijewicz-Nawrot et al.   JOURNAL OF ANATOMY

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Cognitive reserve in ageing and Alzheimer's disease

(2012) Yaakov Stern   LANCET NEUROLOGY

Neurogenic abnormalities in Alzheimer's disease differ between stages of neurogenesis and are partly related to cholinergic pathology

(2012) Elaine K. Perry et al.   NEUROBIOLOGY OF DISEASE

Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment

(2012) L. Scheef et al.   NEUROLOGY

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Astrocytic Atrophy in the Entorhinal Cortex of a Triple Transgenic Animal Model of Alzheimer's Disease

(2011) Chia-Yu Yeh et al.   ASN Neuro

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

(2011) D. Putcha et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Distinct effects of pramipexole on the proliferation of adult mouse sub-ventricular zone-derived cells and the appearance of a neuronal phenotype

(2011) Sara Merlo et al.   NEUROPHARMACOLOGY

Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid

(2011) Volker Nimmrich et al.   REVIEWS IN THE NEUROSCIENCES

Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients

(2010) Christoph Laske et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease

(2010) Feng Luo et al.   NEUROBIOLOGY OF AGING

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

(2010) J. M. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease: brain expression of a metabolic disorder?

(2010) Sara Merlo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model

(2009) Yingxin Yu et al.   HIPPOCAMPUS

Basal Cerebral Metabolism May Modulate the Cognitive Effects of A  in Mild Cognitive Impairment: An Example of Brain Reserve

(2009) A. D. Cohen et al.   JOURNAL OF NEUROSCIENCE

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Oxidative Stress Signaling in Alzheimers Disease

(2008) B. Su et al.   Current Alzheimer Research

Protein Levels and Activity of Some Antioxidant Enzymes in Hippocampus of Subjects with Amnestic Mild Cognitive Impairment

(2008) Rukhsana Sultana et al.   NEUROCHEMICAL RESEARCH

Synaptic proteins, neuropathology and cognitive status in the oldest-old

(2007) Elizabeth Head et al.   NEUROBIOLOGY OF AGING

Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer’s disease-like transgenic (pPDGF-APPSw,Ind) mice

(2007) Li Gan et al.   NEUROBIOLOGY OF DISEASE