Aberrant lipid metabolism as a therapeutic target in liver cancer

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol

(2019) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian Randomization Study of ACLY and Cardiovascular Disease

(2019) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

(2019) Koen H. G. Verschueren et al.   NATURE

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

(2019) Jia Wei et al.   NATURE

Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors

(2018) Qiangqiang Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

(2018) Ghassan K. Abou-Alfa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression

(2018) Weihua Li et al.   Oncotarget

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase

(2017) Steffi K. Koerner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Establishing the foundation for a novel, first-in-class, fatty acid synthase inhibitor, TVB-2640, for the treatment of NASH

(2017) G. Duke et al.   JOURNAL OF HEPATOLOGY

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

(2017) Mark Kin Fai Ma et al.   JOURNAL OF HEPATOLOGY

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner

(2017) Feng-Shu Hsieh et al.   Molecular Oncology

Network analyses identify liver‐specific targets for treating liver diseases

(2017) Sunjae Lee et al.   Molecular Systems Biology

Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target

(2017) Douglas Buckley et al.   PHARMACOLOGY & THERAPEUTICS

Statin use is associated with a reduced risk of hepatocellular carcinoma recurrence after initial liver resection

(2017) Yoshikuni Kawaguchi et al.   BioScience Trends

Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

(2017) Sin-Ting Wang et al.   Cell Death & Disease

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

(2017) Christina A. von Roemeling et al.   Oncotarget

Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells

(2017) Jessica E. C. Jones et al.   PLoS One

Abstract 3781: Combination therapy with a liver selective acetyl-CoA carboxylase inhibitor ND-654 and sorafenib improves efficacy in the treatment of cirrhotic rats with hepatocellular carcinoma

(2016) Lan Wei et al.   CANCER RESEARCH

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

(2016) S. Koyama et al.   CANCER RESEARCH

Circulating CD147 predicts mortality in advanced hepatocellular carcinoma

(2016) Aimei Lee et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma

(2016) Takaaki Higashi et al.   MEDICAL ONCOLOGY

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

(2016) Panayotis C Theodoropoulos et al.   Nature Chemical Biology

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma

(2016) Yao-Yao Zhou et al.   Oncotarget

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

(2016) Ming-Da Wang et al.   Oncotarget

Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells

(2016) Tian-yi Zhou et al.   Scientific Reports

Kruppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6

(2015) H. Sun et al.   CLINICAL CANCER RESEARCH

Targeting lipid metabolism for the treatment of anaplastic thyroid carcinoma

(2015) Christina A von Roemeling et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

(2015) Takashi Muramatsu   JOURNAL OF BIOCHEMISTRY

Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target

(2015) Christina A. von Roemeling et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adenosine triphosphate citrate lyase: Emerging target in the treatment of dyslipidemia

(2015) Hernán N. Lemus et al.   Journal of Clinical Lipidology

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways

(2015) Jibin Li et al.   JOURNAL OF HEPATOLOGY

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

(2015) Xin Tian et al.   Oncotarget

Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

(2014) Maria J. Gutierrez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth

(2014) Yajuan Gao et al.   CANCER LETTERS

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

(2014) Sergey Filippov et al.   CURRENT OPINION IN LIPIDOLOGY

Randomized Trial of [131I] Metuximab in Treatment of Hepatocellular Carcinoma After Percutaneous Radiofrequency Ablation

(2014) Huijie Bian et al.   JNCI-Journal of the National Cancer Institute

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

(2014) Mary Ann Hardwicke et al.   Nature Chemical Biology

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

(2014) Jidong Cheng et al.   PLoS One

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

(2014) Jenny D.Y. Chow et al.   Molecular Metabolism

Efficacy, safety and effect on biomarkers related to cholesterol and lipoprotein metabolism of rosuvastatin 10 or 20 mg plus ezetimibe 10 mg vs. simvastatin 40 or 80 mg plus ezetimibe 10 mg in high-risk patients: Results of the GRAVITY randomized study

(2013) Christie M. Ballantyne et al.   ATHEROSCLEROSIS

Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects

(2013) Shaoyi Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma

(2013) K. Muir et al.   CANCER RESEARCH

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

(2013) C. A. von Roemeling et al.   CLINICAL CANCER RESEARCH

Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease

(2013) Zaihui Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma

(2013) Samiksha Bansal et al.   JOURNAL OF SURGICAL RESEARCH

ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38

(2013) Y. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Treatment of 131I-labeled anti-CD147 monoclonal antibody in VX2 carcinoma-induced liver tumors

(2013) HUANZHANG NIU et al.   ONCOLOGY REPORTS

ATP citrate lyase knockdown impacts cancer stem cells in vitro

(2013) J-i Hanai et al.   Cell Death & Disease

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Monoacylglycerol lipase - a target for drug development?

(2012) CJ Fowler   BRITISH JOURNAL OF PHARMACOLOGY

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

(2012) Stephen L. Pinkosky et al.   JOURNAL OF LIPID RESEARCH

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms

(2012) N. Zaidi et al.   MOLECULAR CANCER THERAPEUTICS

Stearoyl CoA Desaturase 1: Role in Cellular Inflammation and Stress

(2012) Xueqing Liu et al.   Advances in Nutrition

Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer

(2011) Lin Ye et al.   CANCER LETTERS

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

The Global Epidemiology of Hepatocellular Carcinoma: Present and Future

(2011) Katherine A. McGlynn et al.   Clinics in Liver Disease

The interaction of hepatic lipid and glucose metabolism in liver diseases

(2011) Lars P. Bechmann et al.   JOURNAL OF HEPATOLOGY

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

The Glycerophospho Metabolome and Its Influence on Amino Acid Homeostasis Revealed by Brain Metabolomics of GDE1(−/−) Mice

(2010) Florian Kopp et al.   CHEMISTRY & BIOLOGY

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report

(2010) Adeline Guais et al.   INVESTIGATIONAL NEW DRUGS

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

(2010) V. Fritz et al.   MOLECULAR CANCER THERAPEUTICS

A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results

(2010) Schwartz   ONCOLOGY REPORTS

Inhibition of the Liver Enriched Protein FOXA2 Recovers HNF6 Activity in Human Colon Carcinoma and Liver Hepatoma Cells

(2010) Frank Lehner et al.   PLoS One

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

(2009) Dmitry O. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Transcriptional changes associated with reduced spontaneous liver tumor incidence in mice chronically exposed to high dose arsenic

(2009) Gail M. Nelson et al.   TOXICOLOGY

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH