EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Canonical autophagy does not contribute to cellular radioresistance

(2015) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells

(2015) Nina Struve et al.   Oncotarget

Tumor suppression by autophagy through the management of metabolic stress

(2014) Shengkan V. Jin et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

A Minority Subpopulation of CD133+/EGFRvIII+/EGFR−Cells Acquires Stemness and Contributes to Gefitinib Resistance

(2013) Xu-Jie Liu et al.   CNS Neuroscience & Therapeutics

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

(2013) H Feng et al.   ONCOGENE

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

(2013) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma

(2012) C. A. Del Vecchio et al.   CANCER RESEARCH

Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas

(2012) Gordon Li et al.   JOURNAL OF NEURO-ONCOLOGY

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

(2012) H. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-vector inducible lentiviral RNAi system for oncology target validation

(2011) Dmitri Wiederschain et al.   CELL CYCLE

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

(2011) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654

(2010) Klaus Dittmann et al.   FEBS LETTERS

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Considering the role of pyruvate in tumor cells during hypoxia

(2009) Emilie Roudier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

(2009) Elsa-Noah N'Diaye et al.   EMBO REPORTS

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

The EGFRvIII variant in glioblastoma multiforme

(2009) Hui K. Gan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

(2009) D. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment

(2009) Jan Theys et al.   RADIOTHERAPY AND ONCOLOGY

Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells

(2009) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION