Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cells

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

Oncogenic BRAF Alterations and Their Role in Brain Tumors

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Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

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Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

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Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma

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SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways

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Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

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The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

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Recent insights into the function of autophagy in cancer: Table 1.

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Targeting the lysosome in cancer

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SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in cellular metabolism and cancer

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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of autophagy induced by tumor microenvironment in different cells and stages of cancer

(2015) Xue Yang et al.   Cell and Bioscience

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

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Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

Epithelioid GBMs Show a High Percentage of BRAF V600E Mutation

(2013) Bette Kay Kleinschmidt-DeMasters et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

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Atypical Teratoid/Rhabdoid Tumor Arising in a Ganglioglioma

(2011) B.K. Kleinschmidt-DeMasters et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Modulation of pediatric brain tumor autophagy and chemosensitivity

(2011) Jean M. Mulcahy Levy et al.   JOURNAL OF NEURO-ONCOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL