Dietary antioxidants remodel DNA methylation patterns in chronic disease

Chlorogenic acid isomers directly interact with Keap 1-Nrf2 signaling in Caco-2 cells

(2019) Ningjian Liang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Genistein protects against doxorubicin-induced cardiotoxicity through Nrf-2/HO-1 signaling in mice model

(2019) Zhifeng Bai et al.   ENVIRONMENTAL TOXICOLOGY

The Role of Nitric Oxide in Regulating Intestinal Redox Status and Intestinal Epithelial Cell Functionality

(2019) Kaiwen Mu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial

(2019) Homa Hodaei et al.   Diabetology & Metabolic Syndrome

Stilbenoid‐Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor

(2019) Megan Beetch et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo‐controlled clinical trial

(2019) Sahar Saraf‐Bank et al.   PHYTOTHERAPY RESEARCH

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway

(2019) Xinyu Lin et al.   PLoS One

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetics and developmental origins of diabetes: correlation or causation?

(2018) Amita Bansal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci

(2018) Jarrett D. Morrow et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes

(2018) Francisco Barajas-Olmos et al.   BMC Medical Genetics

DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice

(2018) Yue Guo et al.   CARCINOGENESIS

Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats

(2018) Ramoji Kosuru et al.   CARDIOVASCULAR DRUGS AND THERAPY

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner

(2018) Heikki Eräsalo et al.   JOURNAL OF NATURAL PRODUCTS

Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells

(2018) Linbo Gao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

(2018) Marta Starczak et al.   Journal of Translational Medicine

Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation

(2018) Katarzyna Lubecka et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells

(2018) Katja Zappe et al.   Oxidative Medicine and Cellular Longevity

Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy

(2018) Andrea Maugeri et al.   Oxidative Medicine and Cellular Longevity

DNA methylation mediates the effect of maternal cognitive appraisal of a disaster in pregnancy on the child’s C-peptide secretion in adolescence: Project Ice Storm

(2018) Lei Cao-Lei et al.   PLoS One

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

(2018) Rachel L. Clifford et al.   Clinical Epigenetics

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

(2018) Ding Peng et al.   Clinical Epigenetics

All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells

(2018) Xiaohong Sun et al.   Journal of Immunology Research

Chlorogenic acid isomers ameliorate oxidative stress in Caco-2 cells treated with pro-inflammatory proteins by activating the Nrf2/Keap1-ARE signaling pathway

(2018) Ningjian Liang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

(2018) Christian Gerecke et al.   Oncotarget

JAK2 regulates mismatch repair protein‐mediated epigenetic alterations in response to oxidative damage

(2018) Ning Ding et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells

(2018) Nicolas Veland et al.   NUCLEIC ACIDS RESEARCH

DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis

(2018) Dadi Gao et al.   Epigenomics

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

(2018) Sadegh Saghafinia et al.   Cell Reports

DNA methylation variability in Alzheimer's disease

(2018) Zhiguang Huo et al.   NEUROBIOLOGY OF AGING

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

(2017) Weixia Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways

(2017) Sanchari Bhattacharyya et al.   GENOME RESEARCH

Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells

(2017) Kai Qu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?

(2017) Kanwal Rehman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice

(2017) Bodo Speckmann et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line

(2017) Umesh Kumar et al.   TUMOR BIOLOGY

Oxidative stress-induced diseases and tea polyphenols

(2017) Xiangbing Mao et al.   Oncotarget

Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies

(2017) Xinyu Yang et al.   Frontiers in Physiology

Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

(2016) Md. Anisur Rahman Mazumder et al.   BIOMEDICINE & PHARMACOTHERAPY

Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity

(2016) Katarzyna Lubecka et al.   CARCINOGENESIS

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

LPS-induced expression of CD14 in the TRIF pathway is epigenetically regulated by sulforaphane in porcine pulmonary alveolar macrophages

(2016) Qin Yang et al.   Innate Immunity

Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage

(2016) Tanyawan Suantawee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2

(2016) Joo-Hyun Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate

(2016) Roman Thaler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox-active Selenium in Health and Disease: A Conceptual Review

(2016) Boguslaw Lipinski   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter

(2016) Yufei Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells

(2016) Rishabh Kala et al.   PLoS One

Association of interleukin-6 methylation in leukocyte DNA with serum level and the risk of ischemic heart disease

(2016) Qinghui Yang et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells

(2016) Jay Morris et al.   Oncotarget

Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region

(2016) Xiongxiong Liu et al.   Oncotarget

Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol

(2016) Rubiceli Medina-Aguilar et al.   PLoS One

Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis

(2016) Cheng-Chia Yu et al.   Scientific Reports

Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells

(2015) Munawwar Ali Khan et al.   Evidence-based Complementary and Alternative Medicine

Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells

(2015) Katarzyna Lubecka-Pietruszewska et al.   Journal of Nutrigenetics and Nutrigenomics

The complexity of the Nrf2 pathway: beyond the antioxidant response

(2015) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease

(2015) Tammaryn Lashley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

(−)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells

(2015) MUNAWWAR ALI KHAN et al.   ONCOLOGY REPORTS

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation

(2015) Apei Jiang et al.   PHYTOTHERAPY RESEARCH

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage

(2015) Ning Ding et al.   Journal of Molecular Cell Biology

Curcumin Inhibits the AKT/NF-κB Signaling via CpG Demethylation of the Promoter and Restoration of NEP in the N2a Cell Line

(2014) Yushuang Deng et al.   AAPS Journal

Requirement and Epigenetics Reprogramming of Nrf2 in Suppression of Tumor Promoter TPA-Induced Mouse Skin Cell Transformation by Sulforaphane

(2014) Z.-Y. Su et al.   Cancer Prevention Research

Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways

(2014) Bhupendra Singh et al.   CARCINOGENESIS

Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells

(2014) Qi Xie et al.   GENES CHROMOSOMES & CANCER

Vitamin E Conditionally Inhibits Atherosclerosis in ApoE Knockout Mice by Anti-oxidation and Regulation of Vasculature Gene Expressions

(2014) Futian Tang et al.   LIPIDS

Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects

(2014) Valentina Bollati et al.   Nutrients

Modulation of NF-κB and Nrf2 control of inflammatory responses in FHs 74 Int cell line is tocopherol isoform-specific

(2013) Ingrid Elisia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

DNA Methylation Is Globally Disrupted and Associated with Expression Changes in Chronic Obstructive Pulmonary Disease Small Airways

(2013) Emily A. Vucic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

(2013) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Different tocopherol isoforms vary in capacity to scavenge free radicals, prevent inflammatory response, and induce apoptosis in both adult- and fetal-derived intestinal epithelial cells

(2013) Ingrid Elisia et al.   BIOFACTORS

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

(2013) Elin Hall et al.   BMC Medical Genetics

Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2

(2013) Barbara Stefanska et al.   CARCINOGENESIS

Chromatin modifications during repair of environmental exposure-induced DNA damage: A potential mechanism for stable epigenetic alterations

(2013) Heather M. O'Hagan   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

(2013) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation

(2013) Atsushi Iwata et al.   HUMAN MOLECULAR GENETICS

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins

(2013) Sameer Mirza et al.   Journal of Breast Cancer

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epigallocatechin-3-Gallate Inhibits Homocysteine-Induced Apoptosis of Endothelial Cells by Demethylation of the DDAH2 Gene

(2013) Bi-Kui Zhang et al.   PLANTA MEDICA

Cytosine Methylation Alteration in Natural Populations of Leymus chinensis Induced by Multiple Abiotic Stresses

(2013) Yingjie Yu et al.   PLoS One

Curcumin Modulates DNA Methylation in Colorectal Cancer Cells

(2013) Alexander Link et al.   PLoS One

Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa

(2012) Henri S. Tapp et al.   AGING CELL

A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation

(2012) Ying Huang et al.   JOURNAL OF NUTRITION

EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes

(2012) Sung Gu Han et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells

(2011) Barbara Stefanska et al.   BRITISH JOURNAL OF NUTRITION

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

Definition of the Landscape of Promoter DNA Hypomethylation in Liver Cancer

(2011) B. Stefanska et al.   CANCER RESEARCH

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats

(2011) Junwei Ren et al.   NEUROCHEMICAL RESEARCH

DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines

(2011) Mawussi Adjakly et al.   Epigenomics

The von Hippel-Lindau (VHL) Tumor-suppressor Gene is Down-regulated by Selenium Deficiency in Caco-2 Cells and Rat Colon Mucosa

(2010) Eric Uthus et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

MicroRNA Mediates DNA Demethylation Events Triggered by Retinoic Acid during Neuroblastoma Cell Differentiation

(2010) S. Das et al.   CANCER RESEARCH

Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells

(2010) Barbara Stefanska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells

(2010) Andreas J. Papoutsis et al.   JOURNAL OF NUTRITION

Regulation and function of selenoproteins in human disease

(2009) Frederick P. Bellinger et al.   BIOCHEMICAL JOURNAL

Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer

(2009) Shahana Majid et al.   CANCER

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Soy Isoflavones Have an Antiestrogenic Effect and Alter Mammary Promoter Hypermethylation in Healthy Premenopausal Women

(2009) Wenyi Qin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells

(2008) K Kato et al.   BRITISH JOURNAL OF CANCER

Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells

(2008) Nong Xiang et al.   CARCINOGENESIS

Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer’s disease in C57BL/6J mice treated with d-galactose

(2008) Huei-Min Hsieh et al.   FOOD AND CHEMICAL TOXICOLOGY

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

(2008) Heather M. O'Hagan et al.   PLoS Genetics

Review: Antioxidant therapeutic advances in COPD

(2008) Irfan Rahman   Therapeutic Advances in Respiratory Disease

On the mechanism of demethylation of 5-methylcytosine in DNA

(2007) Stefan Hamm et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS