In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

(2017) Yang W. Zhang et al.   MOLECULAR CELL

Accurate, Direct, and High-Throughput Analyses of a Broad Spectrum of Endogenously Generated DNA Base Modifications with Isotope-Dilution Two-Dimensional Ultraperformance Liquid Chromatography with Tandem Mass Spectrometry: Possible Clinical Implication

(2016) Daniel Gackowski et al.   ANALYTICAL CHEMISTRY

Vitamin C enhances substantially formation of 5-hydroxymethyluracil in cellular DNA

(2016) Martyna Modrzejewska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism

(2016) Daniel J. Crawford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine

(2016) Jun Xiong et al.   MOLECULAR CELL

Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?

(2016) Ryszard Olinski et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine

(2016) Monica Yun Liu et al.   Nature Chemical Biology

MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma

(2016) Dongxue Wang et al.   NUCLEIC ACIDS RESEARCH

Vitamin C: the known and the unknown and Goldilocks

(2016) SJ Padayatty et al.   ORAL DISEASES

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

(2016) Timothy Alexander Hore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of environmental exposure on human epigenetic regulation

(2015) C. J. Marsit   JOURNAL OF EXPERIMENTAL BIOLOGY

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4

(2015) JI CHENG et al.   ONCOLOGY REPORTS

Mechanisms of Superoxide Signaling in Epigenetic Processes: Relation to Aging and Cancer

(2015) Igor Afanas’ev   Aging and Disease

Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships

(2015) Daniel Gackowski et al.   PLoS One

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

(2014) Hao Wu et al.   CELL

Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine

(2014) Erika L. Moen et al.   IMMUNOLOGICAL REVIEWS

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

(2014) Toni Pfaffeneder et al.   Nature Chemical Biology

Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA

(2014) G. S. Madugundu et al.   NUCLEIC ACIDS RESEARCH

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

(2011) S.-G. Jin et al.   CANCER RESEARCH

DNA Demethylation Dynamics

(2011) Nidhi Bhutani et al.   CELL

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients

(2010) T. Obtulowicz et al.   MUTAGENESIS

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

Inflammation and colorectal cancer

(2009) Sarah Kraus et al.   CURRENT OPINION IN PHARMACOLOGY

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE