Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington’s disease-like phenotype in BACHD mice

(2019) Terri L Petkau et al.   HUMAN MOLECULAR GENETICS

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

(2019) Arshed Nazmi et al.   GLIA

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

(2019) James W. Fawcett et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics

(2019) Lisa M. Stanek et al.   NEUROBIOLOGY OF DISEASE

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

(2019) Jian Jing Siew et al.   Nature Communications

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype

(2018) Shunsuke Koga et al.   ACTA NEUROPATHOLOGICA

Repeated immune activation with low-dose lipopolysaccharide attenuates the severity of Huntington's disease in R6/2 transgenic mice

(2018) Sung Won Lee et al.   Animal Cells and Systems

Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks

(2018) Ioanna Sandvig et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

(2018) Craig S Pearson et al.   eLife

Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply

(2018) Hao Zhang et al.   Autophagy

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model

(2018) Tomer Illouz et al.   BRAIN BEHAVIOR AND IMMUNITY

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Human ESC-Derived Chimeric Mouse Models of Huntington’s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation

(2018) Mikhail Osipovitch et al.   Cell Stem Cell

A limited capacity for microglial repopulation in the adult brain

(2018) Allison R. Najafi et al.   GLIA

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

(2018) Bhanu P. Tewari et al.   Nature Communications

Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation

(2018) Shagun R. Mehta et al.   Cell Reports

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

(2017) Ryan G Lim et al.   NATURE NEUROSCIENCE

Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning

(2017) Sunayana B. Banerjee et al.   NEURON

Brain interference: Revisiting the role of IFNγ in the central nervous system

(2017) S. Monteiro et al.   PROGRESS IN NEUROBIOLOGY

Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) function as endocytic receptors for an internalizing anti-nucleic acid antibody

(2017) Hyunjoon Park et al.   Scientific Reports

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Microglial Activation in the Pathogenesis of Huntington’s Disease

(2017) Hui-Ming Yang et al.   Frontiers in Aging Neuroscience

Hyaluronan synthesis by developing cortical neurons in vitro

(2017) Tania M. Fowke et al.   Scientific Reports

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Faulty splicing and cytoskeleton abnormalities in Huntington's disease

(2016) Marta Fernández-Nogales et al.   BRAIN PATHOLOGY

MAP2 Splicing is Altered in Huntington's Disease

(2016) Jorge Rubén Cabrera et al.   BRAIN PATHOLOGY

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

(2016) Anne H.P. Jansen et al.   GLIA

Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage

(2016) Minshu Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

(2016) Xi Feng et al.   Journal of Neuroinflammation

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity

(2016) Barbara A. Sorg et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

(2016) Joseph Ochaba et al.   NEURON

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

(2016) Abdellatif Benraiss et al.   Nature Communications

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington’s Disease

(2016) Filipe Brogueira Rodrigues et al.   PLoS One

Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons

(2016) Yosuke Ohtake et al.   Scientific Reports

Plasma inflammatory biomarkers for Huntington’s disease patients and mouse model

(2015) Kuo-Hsuan Chang et al.   BRAIN BEHAVIOR AND IMMUNITY

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Involvement of chondroitin 6-sulfation in temporal lobe epilepsy

(2015) Noriko Yutsudo et al.   EXPERIMENTAL NEUROLOGY

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

(2015) Filipa L Cardoso et al.   Journal of Neuroinflammation

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

(2015) Bibiana K.Y. Wong et al.   NEUROBIOLOGY OF DISEASE

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination

(2015) Mattias N. D. Svensson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The choreography of neuroinflammation in Huntington's disease

(2015) Andrea Crotti et al.   TRENDS IN IMMUNOLOGY

CD44: molecular interactions, signaling and functions in the nervous system

(2015) Joanna Dzwonek et al.   Frontiers in Cellular Neuroscience

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala

(2015) H Pantazopoulos et al.   Translational Psychiatry

Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review

(2015) Nicolas D. Iadarola et al.   Therapeutic Advances in Chronic Disease

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

(2014) Masaru Kurosawa et al.   HUMAN MOLECULAR GENETICS

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

(2014) Colin G McNamara et al.   NATURE NEUROSCIENCE

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum

(2014) Haruko Miyazaki et al.   Nature Communications

Skeletal muscle pathology in Huntington's disease

(2014) Daniel Zielonka et al.   Frontiers in Physiology

Striatal oligodendrogliogenesis and neuroblast recruitment are increased in the R6/2 mouse model of Huntington's disease

(2013) Mark H. McCollum et al.   BRAIN RESEARCH

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

(2013) S. Mok et al.   CANCER RESEARCH

The transcription factor PU.1 is critical for viability and function of human brain microglia

(2013) Amy M. Smith et al.   GLIA

Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation

(2013) M. Geissler et al.   JOURNAL OF NEUROSCIENCE

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia

(2013) Anton Reiner et al.   MOVEMENT DISORDERS

Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of α-Synuclein

(2013) Simon M. L. Paine et al.   PLoS One

A Novel Null Homozygous Mutation Confirms CACNA2D2 as a Gene Mutated in Epileptic Encephalopathy

(2013) Tommaso Pippucci et al.   PLoS One

Targeting H3K4 trimethylation in Huntington disease

(2013) M. Vashishtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The perineuronal net and the control of CNS plasticity

(2012) Difei Wang et al.   CELL AND TISSUE RESEARCH

Persistent cortical plasticity by upregulation of chondroitin 6-sulfation

(2012) Shinji Miyata et al.   NATURE NEUROSCIENCE

CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model

(2012) Tomohiro Matsumoto et al.   NEUROSCIENCE LETTERS

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation

(2012) Carl Julien et al.   PLoS One

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Dysfunction of microtubule-associated proteins of MAP2/tau family in Prion disease

(2012) Jin Zhang et al.   Prion

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

(2011) Huikyong Lee et al.   HUMAN MOLECULAR GENETICS

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

Isl1 Is required for multiple aspects of motor neuron development

(2011) Xingqun Liang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

(2011) Andrew D. Kraft et al.   NEUROBIOLOGY OF AGING

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study

(2010) Marios Politis et al.   HUMAN BRAIN MAPPING

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease

(2009) Hilary Moffitt et al.   PLoS One

Loss of Perineuronal Net in ME7 Prion Disease

(2008) Sarah L. Franklin et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

(2008) H. Runne et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9 Facilitates Glial Scar Formation in the Injured Spinal Cord

(2008) J.-Y. C. Hsu et al.   JOURNAL OF NEUROSCIENCE

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

The LIM-Homeobox Gene Islet-1 Is Required for the Development of Restricted Forebrain Cholinergic Neurons

(2008) Y. Elshatory et al.   JOURNAL OF NEUROSCIENCE