EZH2 function in immune cell development

Towards understanding of PRC2 binding to RNA

(2019) Junli Yan et al.   RNA Biology

EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation

(2019) Laurie Herviou et al.   LEUKEMIA

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

(2019) Shenda Hou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology

(2019) Damon Tumes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cis-Regulatory Atlas of the Mouse Immune System

(2019) Hideyuki Yoshida et al.   CELL

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation

(2019) Anne Laugesen et al.   MOLECULAR CELL

Inhibition of EZH 2 ameliorates lupus‐like disease in MRL / lpr mice

(2019) Dallas M. Rohraff et al.   Arthritis & Rheumatology

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

(2019) Jie Zhou et al.   Nature Communications

T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells

(2019) Nyambayar Dashtsoodol et al.   Frontiers in Immunology

The Complexity of PRC2 Subcomplexes

(2019) Guido van Mierlo et al.   TRENDS IN CELL BIOLOGY

Oncogenic roles of enhancer of zeste homolog 1/2 in hematological malignancies

(2018) Makoto Nakagawa et al.   CANCER SCIENCE

Signaling function of PRC2 is essential for TCR-driven T cell responses

(2018) Marc-Werner Dobenecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

(2018) Xingli Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancer of zeste homolog 2 (EZH2) inhibitors

(2018) Nitya Gulati et al.   LEUKEMIA & LYMPHOMA

MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding

(2018) Matteo Perino et al.   NATURE GENETICS

Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity

(2018) Myriam Koubi et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells

(2018) Suresh Bugide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs

(2018) Christopher D. Scharer et al.   Nature Communications

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

(2018) David Wang et al.   Cell Reports

Ezh2 Regulates Activation-Induced CD8+ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression

(2018) Guobing Chen et al.   Frontiers in Immunology

Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy

(2018) Sangeeta Goswami et al.   JOURNAL OF CLINICAL INVESTIGATION

Ezh2 loss propagates hypermethylation at T cell differentiation–regulating genes to promote leukemic transformation

(2018) Changshan Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

(2018) Fengyin Li et al.   Nature Communications

Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 + T Cell Terminal Differentiation and Loss of Multipotency

(2017) Simon M. Gray et al.   IMMUNITY

Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb

(2017) Sheila Dias et al.   IMMUNITY

EZH2 Regulates the Developmental Timing of Effectors of the Pre–Antigen Receptor Checkpoints

(2017) Jennifer A. Jacobsen et al.   JOURNAL OF IMMUNOLOGY

EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production

(2017) Muyao Guo et al.   JOURNAL OF IMMUNOLOGY

Polycomb-like proteins link the PRC2 complex to CpG islands

(2017) Haojie Li et al.   NATURE

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop

(2017) Wendy Béguelin et al.   Nature Communications

Shaping Innate Lymphoid Cell Diversity

(2017) Qiutong Huang et al.   Frontiers in Immunology

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

(2016) Wendy Béguelin et al.   CANCER CELL

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)

(2016) Olga F. Sarmento et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

(2016) Martina Minnich et al.   NATURE IMMUNOLOGY

Regulatory T Cells: Differentiation and Function

(2016) G. Plitas et al.   Cancer Immunology Research

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

(2015) S. C. W. Lee et al.   BLOOD

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

(2015) M. Mochizuki-Kashio et al.   BLOOD

The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

(2015) Michel DuPage et al.   IMMUNITY

Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation

(2015) Marc-Werner Dobenecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

(2015) Merry Gunawan et al.   NATURE IMMUNOLOGY

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity

(2015) Jie Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion

(2015) Xiang-Ping Yang et al.   Scientific Reports

The polycomb repressive complex 2 governs life and death of peripheral T cells

(2014) Y. Zhang et al.   BLOOD

Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway

(2014) W Zhang et al.   CELL DEATH AND DIFFERENTIATION

Ezh2 Regulates Transcriptional and Posttranslational Expression of T-bet and Promotes Th1 Cell Responses Mediating Aplastic Anemia in Mice

(2014) Q. Tong et al.   JOURNAL OF IMMUNOLOGY

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

(2014) Aaron Arvey et al.   NATURE IMMUNOLOGY

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

(2013) S. He et al.   BLOOD

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

(2013) Huafeng Xie et al.   Cell Stem Cell

The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells

(2013) Damon J. Tumes et al.   IMMUNITY

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

(2013) Marieta Caganova et al.   JOURNAL OF CLINICAL INVESTIGATION

EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex

(2012) Ji Min Lee et al.   MOLECULAR CELL

An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting

(2012) Ling Cai et al.   MOLECULAR CELL

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

(2012) Cecilia Ballaré et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differentiation and function of Foxp3+ effector regulatory T cells

(2012) Erika Cretney et al.   TRENDS IN IMMUNOLOGY

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

(2011) M. Mochizuki-Kashio et al.   BLOOD

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

(2010) I. Velichutina et al.   BLOOD

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

(2010) I. J. Majewski et al.   BLOOD