The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses

(2013) P Tripathi et al.   CELL DEATH AND DIFFERENTIATION

Histone methyltransferase and histone methylation in inflammatory T-cell responses

(2013) Shan He et al.   Immunotherapy

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Delta-like Ligand 4 Identifies a Previously Uncharacterized Population of Inflammatory Dendritic Cells That Plays Important Roles in Eliciting Allogeneic T Cell Responses in Mice

(2013) K. Mochizuki et al.   JOURNAL OF IMMUNOLOGY

Emerging roles for chromatin as a signal integration and storage platform

(2013) Aimee I. Badeaux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of GVHD: it's in our DNA!

(2012) N. Chao   BLOOD

DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival

(2012) Daniel D. De Carvalho et al.   CANCER CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

(2011) S. He et al.   BLOOD

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(2011) Sung Choi et al.   MOLECULAR MEDICINE

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Identification of Stem Cell Transcriptional Programs Normally Expressed in Embryonic and Neural Stem Cells in Alloreactive CD8+ T Cells Mediating Graft-versus-Host Disease

(2010) Koji Kato et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia

(2010) J. Choi et al.   BLOOD

Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation

(2010) Y. Shono et al.   BLOOD

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease

(2010) Y. Zhang et al.   BLOOD

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting

(2009) L. I. Sanchez-Abarca et al.   BLOOD

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

(2009) Javier O. Valenzuela et al.   JOURNAL OF CLINICAL INVESTIGATION

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease

(2009) Il-Kang Na et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

(2009) P. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Graft-versus-leukemia effects of transplantation and donor lymphocytes

(2008) H.-J. Kolb   BLOOD

Unconventional Association of the Polycomb Group Proteins with Cytokine Genes in Differentiated T Helper Cells

(2008) Eyal Jacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice

(2008) Pavan Reddy et al.   JOURNAL OF CLINICAL INVESTIGATION