Journal
FRONTIERS IN IMMUNOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01569
Keywords
innate immunity; differentiation; gene expression; immune protection; innate lymphoid cell
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Funding
- National Health and Medical Research Council (NHMRC) of Australia [1047903, 1054925]
- Australian Research Council Future Fellowship
- Rebecca L. Cooper Foundation Medical Research Foundation
- Page Betheras Award
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Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation. We present here the most recent understanding of how genomics has provided significant insight into how ILCs are generated and the enormous heterogeneity present within the canonical subsets. This has allowed the generation of a detailed blueprint for ILCs to become highly sensitive and adaptive sensors of environmental changes and therefore exquisitely equipped to protect immune surfaces.
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